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Insulin‐like Growth Factor 1 and Functional Status in Healthy Older Men

Insulin‐like Growth Factor 1 and Functional Status in Healthy Older Men OBJECTIVE: To determine if insulin‐like growth factor 1 (IGF‐1) is associated with strength and functional ability in healthy older men. DESIGN: Cross‐sectional study. SETTING: San Francisco Department of Veterans Affairs Medical Center. PARTICIPANTS: One hundred four ambulatory community‐dwelling men. MEASUREMENTS: Serum IGF‐1 levels were obtained. Measured variables included strength of the knee flexors and extensors, handgrip, score on the Physical Performance Test, body composition, and three tests of cognitive function. RESULTS: The subjects' mean age was 75.5±4.9 (SD) years (range 70–94 years), and their mean IGF‐1 level was 134.7±43.6 ng/mL. The univariate association of age with the variables was much stronger than the univariate association of IGF‐1 with the same variables. In multivariable models, age, but not IGF‐1, was associated with the variables. CONCLUSION: In this study of healthy older men, age is the most important variable in predicting functional decline. There was no association of IGF‐1 levels to functional status independent of age. J Am Geriatr Soc 43:1350–1355,1995. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

Insulin‐like Growth Factor 1 and Functional Status in Healthy Older Men

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References (64)

Publisher
Wiley
Copyright
1995 The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
DOI
10.1111/j.1532-5415.1995.tb06613.x
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVE: To determine if insulin‐like growth factor 1 (IGF‐1) is associated with strength and functional ability in healthy older men. DESIGN: Cross‐sectional study. SETTING: San Francisco Department of Veterans Affairs Medical Center. PARTICIPANTS: One hundred four ambulatory community‐dwelling men. MEASUREMENTS: Serum IGF‐1 levels were obtained. Measured variables included strength of the knee flexors and extensors, handgrip, score on the Physical Performance Test, body composition, and three tests of cognitive function. RESULTS: The subjects' mean age was 75.5±4.9 (SD) years (range 70–94 years), and their mean IGF‐1 level was 134.7±43.6 ng/mL. The univariate association of age with the variables was much stronger than the univariate association of IGF‐1 with the same variables. In multivariable models, age, but not IGF‐1, was associated with the variables. CONCLUSION: In this study of healthy older men, age is the most important variable in predicting functional decline. There was no association of IGF‐1 levels to functional status independent of age. J Am Geriatr Soc 43:1350–1355,1995.

Journal

Journal of American Geriatrics Society – Wiley

Published: Dec 1, 1995

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