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- Publisher
- Wiley
- Copyright
- © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2003
- ISSN
- 1474-9718
- DOI
- 10.1046/j.1474-9728.2003.00063.x
- pmid
- 14677634
- Publisher site
- See Article on Publisher Site
Abstract
Summary The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF-I-like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.
Journal
Aging Cell – Wiley
Published: Dec 1, 2003
Keywords: antioxidants; Caenorhabditis elegans ; oxidative stress; SOD; catalase mimetics; stress resistance