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Evolutionary plasticity of protein families: Coupling between sequence and structure variation

Evolutionary plasticity of protein families: Coupling between sequence and structure variation In this work we examine how protein structural changes are coupled with sequence variation in the course of evolution of a family of homologs. The sequence–structure correlation analysis performed on 81 homologous protein families shows that the majority of them exhibit statistically significant linear correlation between the measures of sequence and structural similarity. We observed, however, that there are cases where structural variability cannot be mainly explained by sequence variation, such as protein families with a number of disulfide bonds. To understand whether structures from different families and/or folds evolve in the same manner, we compared the degrees of structural change per unit of sequence change (“the evolutionary plasticity of structure”) between those families with a significant linear correlation. Using rigorous statistical procedures we find that, with a few exceptions, evolutionary plasticity does not show a statistically significant difference between protein families. Similar sequence–structure analysis performed for protein loop regions shows that evolutionary plasticity of loop regions is greater than for the protein core. Proteins 2005. © 2005 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proteins: Structure Function and Bioinformatics Wiley

Evolutionary plasticity of protein families: Coupling between sequence and structure variation

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References (45)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
0887-3585
eISSN
1097-0134
DOI
10.1002/prot.20644
pmid
16184609
Publisher site
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Abstract

In this work we examine how protein structural changes are coupled with sequence variation in the course of evolution of a family of homologs. The sequence–structure correlation analysis performed on 81 homologous protein families shows that the majority of them exhibit statistically significant linear correlation between the measures of sequence and structural similarity. We observed, however, that there are cases where structural variability cannot be mainly explained by sequence variation, such as protein families with a number of disulfide bonds. To understand whether structures from different families and/or folds evolve in the same manner, we compared the degrees of structural change per unit of sequence change (“the evolutionary plasticity of structure”) between those families with a significant linear correlation. Using rigorous statistical procedures we find that, with a few exceptions, evolutionary plasticity does not show a statistically significant difference between protein families. Similar sequence–structure analysis performed for protein loop regions shows that evolutionary plasticity of loop regions is greater than for the protein core. Proteins 2005. © 2005 Wiley‐Liss, Inc.

Journal

Proteins: Structure Function and Bioinformatics – Wiley

Published: Jan 15, 2005

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