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Immunoregulatory functions of surfactant proteins

Immunoregulatory functions of surfactant proteins Surfactant protein A (SP-A)and SP-D are members of a family of immune proteins known as collectins, or collagen-like lectins. SP-A and SP-D interact with various pathogens through their lectin domains and enhance pathogen uptake by phagocytes. SP-A and SP-D regulate functions of a variety of immune cells, including dendritic cells, T cells, neutrophils and macrophages. SP-A- and SP-D-null mice have an increased susceptibility to infection and inflammation. Recent studies indicate that SP-A and SP-D might function at sites in addition to the lung, where they were first discovered and are most abundant. SP-A has been shown to initiate an inflammatory response in the uterus and to induce labour. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Immunology Springer Journals

Immunoregulatory functions of surfactant proteins

Nature Reviews Immunology , Volume 5 (1) – Jan 1, 2005

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References (166)

Publisher
Springer Journals
Copyright
Copyright © 2005 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Immunology
ISSN
1474-1733
eISSN
1474-1741
DOI
10.1038/nri1528
Publisher site
See Article on Publisher Site

Abstract

Surfactant protein A (SP-A)and SP-D are members of a family of immune proteins known as collectins, or collagen-like lectins. SP-A and SP-D interact with various pathogens through their lectin domains and enhance pathogen uptake by phagocytes. SP-A and SP-D regulate functions of a variety of immune cells, including dendritic cells, T cells, neutrophils and macrophages. SP-A- and SP-D-null mice have an increased susceptibility to infection and inflammation. Recent studies indicate that SP-A and SP-D might function at sites in addition to the lung, where they were first discovered and are most abundant. SP-A has been shown to initiate an inflammatory response in the uterus and to induce labour.

Journal

Nature Reviews ImmunologySpringer Journals

Published: Jan 1, 2005

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