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Surfactant protein A (SP-A)and SP-D are members of a family of immune proteins known as collectins, or collagen-like lectins. SP-A and SP-D interact with various pathogens through their lectin domains and enhance pathogen uptake by phagocytes. SP-A and SP-D regulate functions of a variety of immune cells, including dendritic cells, T cells, neutrophils and macrophages. SP-A- and SP-D-null mice have an increased susceptibility to infection and inflammation. Recent studies indicate that SP-A and SP-D might function at sites in addition to the lung, where they were first discovered and are most abundant. SP-A has been shown to initiate an inflammatory response in the uterus and to induce labour.
Nature Reviews Immunology – Springer Journals
Published: Jan 1, 2005
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