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The action of calcium at spinal neurones of the frog

The action of calcium at spinal neurones of the frog 1. The action of Ca on membrane excitability and synaptic transmission at motoneurones of the isolated spinal cord of the frog has been studied. 2. Impulse propagation along presynaptic fibres was unaffected by (Ca) in the range of 0–10 m M in the presence of 1 m M‐Mg. 3. Motoneurone membrane excitability was within normal ranges when the cord was bathed in low or 0 Ca solutions containing 1 m M‐Mg but was depressed in 5 or 10 m M‐Ca solutions. 4. Spontaneous miniature synaptic potentials were recorded in the presence of tetrodotoxin. The frequencies were reduced but not abolished in the absence of bath Ca, but were increased greater than twofold in 5 or 10 m M‐Ca in comparison to those in normal Ringer solution (1 m M‐Ca). 5. Iontophoretic application of Ca both near to and remotely from the intracellular recording site (presumably in the soma) caused facilitation of elicited post‐synaptic potentials. 6. It is concluded that the action of Ca at these central synapses is identical to that described at the neuromuscular junction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

The action of calcium at spinal neurones of the frog

Dambach, G. E.; Erulkar, S. D.
The Journal of Physiology , Volume 228 (3) – Feb 1, 1973
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References (35)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1973.sp010113
Publisher site
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Abstract

1. The action of Ca on membrane excitability and synaptic transmission at motoneurones of the isolated spinal cord of the frog has been studied. 2. Impulse propagation along presynaptic fibres was unaffected by (Ca) in the range of 0–10 m M in the presence of 1 m M‐Mg. 3. Motoneurone membrane excitability was within normal ranges when the cord was bathed in low or 0 Ca solutions containing 1 m M‐Mg but was depressed in 5 or 10 m M‐Ca solutions. 4. Spontaneous miniature synaptic potentials were recorded in the presence of tetrodotoxin. The frequencies were reduced but not abolished in the absence of bath Ca, but were increased greater than twofold in 5 or 10 m M‐Ca in comparison to those in normal Ringer solution (1 m M‐Ca). 5. Iontophoretic application of Ca both near to and remotely from the intracellular recording site (presumably in the soma) caused facilitation of elicited post‐synaptic potentials. 6. It is concluded that the action of Ca at these central synapses is identical to that described at the neuromuscular junction.

Journal

The Journal of Physiology – Wiley

Published: Feb 1, 1973

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