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Effective treatment and prophylaxis of hyperuricemia and impaired renal function in tumor lysis syndrome with low doses of rasburicase

Effective treatment and prophylaxis of hyperuricemia and impaired renal function in tumor lysis... Background: Tumor lysis syndrome (TLS) is a complication that can cause renal failure by precipitation of uric acid (UA) and phosphate crystals in renal tubules. Rasburicase proved to be effective in rapidly reducing UA levels. Costs of rasburicase average up to 4500€. To assess if lower doses of rasburicase are effective, we treated patients with lower doses than recommended. Patients and methods: Fifty patients received rasburicase for prophylaxis (n = 8) or treatment (n = 42) of TLS. The median age was 67 yr (16–88), 21 were female. The majority of patients (n = 46) had hematologic malignancies (acute leukemia, 14; lymphoma, 26; myeloproliferative/myelodysplastic syndromes, 6) and four had solid tumors. Creatinine levels were increased in 42 patients. Results: Baseline median UA and creatinine levels were 856.5 μmol/L (339–1659.5 μmol/L) and 192.7 μmol/L (65.4–761.1 μmol/L), respectively. Patients received between one and eight doses of rasburicase, the median total dose was 0.049 mg/kg. UA levels were lowered by 83%. After rasburicase treatment, median serum UA and creatinine levels were 160.6 μmol/L (5.9–779.2 μmol/L) and 111.4 μmol/L (46.9–610 μmol/L), respectively. Treatment costs were reduced by 96.8%. Conclusions: Low doses of rasburicase are effective and cost‐saving for prophylaxis and treatment of TLS. Application of an initial dose of 3–4.5 mg of rasburicase and subsequently dosage as needed, depending on UA levels, is feasible. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Haematology Wiley

Effective treatment and prophylaxis of hyperuricemia and impaired renal function in tumor lysis syndrome with low doses of rasburicase

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References (25)

Publisher
Wiley
Copyright
© 2008 The Authors
ISSN
0902-4441
eISSN
1600-0609
DOI
10.1111/j.1600-0609.2007.01013.x
pmid
18081720
Publisher site
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Abstract

Background: Tumor lysis syndrome (TLS) is a complication that can cause renal failure by precipitation of uric acid (UA) and phosphate crystals in renal tubules. Rasburicase proved to be effective in rapidly reducing UA levels. Costs of rasburicase average up to 4500€. To assess if lower doses of rasburicase are effective, we treated patients with lower doses than recommended. Patients and methods: Fifty patients received rasburicase for prophylaxis (n = 8) or treatment (n = 42) of TLS. The median age was 67 yr (16–88), 21 were female. The majority of patients (n = 46) had hematologic malignancies (acute leukemia, 14; lymphoma, 26; myeloproliferative/myelodysplastic syndromes, 6) and four had solid tumors. Creatinine levels were increased in 42 patients. Results: Baseline median UA and creatinine levels were 856.5 μmol/L (339–1659.5 μmol/L) and 192.7 μmol/L (65.4–761.1 μmol/L), respectively. Patients received between one and eight doses of rasburicase, the median total dose was 0.049 mg/kg. UA levels were lowered by 83%. After rasburicase treatment, median serum UA and creatinine levels were 160.6 μmol/L (5.9–779.2 μmol/L) and 111.4 μmol/L (46.9–610 μmol/L), respectively. Treatment costs were reduced by 96.8%. Conclusions: Low doses of rasburicase are effective and cost‐saving for prophylaxis and treatment of TLS. Application of an initial dose of 3–4.5 mg of rasburicase and subsequently dosage as needed, depending on UA levels, is feasible.

Journal

European Journal of Haematology – Wiley

Published: Apr 1, 2008

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