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Unified nomenclature for the winged helix/forkhead transcription factors

Unified nomenclature for the winged helix/forkhead transcription factors Downloaded from genesdev.cshlp.org on April 5, 2022 - Published by Cold Spring Harbor Laboratory Press CORRESPONDENCE Unified nomenclature for the winged helix/forkhead transcription factors 1,4,5 2,4 3,4,5 Klaus H. Kaestner, Walter Kno ¨ chel, and Daniel E. Martı ´nez Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA; 2 3 Abteilung Biochemie, Universita ¨ t Ulm, D-89081 Ulm, Germany; Department of Biology, Pomona College, Claremont, California 91711 USA The winged helix/forkhead class of transcription factors scription factors. Other portions of the Fox proteins, is characterized by a 100-amino-acid, monomeric DNA- which encode, for instance, transactivation or trans-re- binding domain. The structure of the DNA-binding do- pression domains, are highly divergent. We have utilized main of one of the class members, hepatocyte nuclear phylogenetic analysis to delineate 15 subclasses for all factor 3 g (HNF3g), in a complex with a DNA target has known chordate Fox proteins. The analysis included been solved (Clark et al. 1993). The DNA-binding do- chordate sequences obtained from GenBank and se- main folds into a variant of the helix–turn–helix motif quences submitted directly to the nomenclature com- and is made up of three a helices and two characteristic mittee. The Fox http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Unified nomenclature for the winged helix/forkhead transcription factors

Kaestner, Klaus H.; Knöchel, Walter; Martínez, Daniel E.
Genes & Development – Jan 15, 2000
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Unpaywall
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0890-9369
DOI
10.1101/gad.14.2.142
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Abstract

Downloaded from genesdev.cshlp.org on April 5, 2022 - Published by Cold Spring Harbor Laboratory Press CORRESPONDENCE Unified nomenclature for the winged helix/forkhead transcription factors 1,4,5 2,4 3,4,5 Klaus H. Kaestner, Walter Kno ¨ chel, and Daniel E. Martı ´nez Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA; 2 3 Abteilung Biochemie, Universita ¨ t Ulm, D-89081 Ulm, Germany; Department of Biology, Pomona College, Claremont, California 91711 USA The winged helix/forkhead class of transcription factors scription factors. Other portions of the Fox proteins, is characterized by a 100-amino-acid, monomeric DNA- which encode, for instance, transactivation or trans-re- binding domain. The structure of the DNA-binding do- pression domains, are highly divergent. We have utilized main of one of the class members, hepatocyte nuclear phylogenetic analysis to delineate 15 subclasses for all factor 3 g (HNF3g), in a complex with a DNA target has known chordate Fox proteins. The analysis included been solved (Clark et al. 1993). The DNA-binding do- chordate sequences obtained from GenBank and se- main folds into a variant of the helix–turn–helix motif quences submitted directly to the nomenclature com- and is made up of three a helices and two characteristic mittee. The Fox

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Genes & Development – Unpaywall

Published: Jan 15, 2000

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