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Large Duct Epithelial Hyperplasia and Carcinoma of the Breast

Large Duct Epithelial Hyperplasia and Carcinoma of the Breast Abstract IN A previous study by Humphrey and Swerdlow1 the finding of large duct epithelial hyperplasia in 69% of breasts removed for carcinoma was reported. A similar type of hyperplasia was also present in eight of 14 (64%) benign breast lesions excised 1 to 13 years before the development of carcinoma. On the other hand, only nine of 61 (16%) benign lesions that were diagnosed as fibrocystic disease and in which carcinoma did not develop were found to have large duct epithelial hyperplasia. This method of histologic examination as originally described2 stressed the importance of separating epithelial hyperplasia of large and small ducts. With this strong correlation between large duct epithelial hyperplasia and carcinoma of the breast, a study was initiated to determine, if possible, the natural history of this specific histologic lesion. Methods From records and slides reviewed in the original study, there were 63 breast biopsies performed between 1946 References 1. Humphrey, L.J., and Swerdlow, M.: Relationship of Benign Breast Disease to Carcinoma of the Breast , Surgery 52:841-846 ( (Dec) ) 1962. 2. Swerdlow, M., and Humphrey, L.J.: Fibrocystic Disease and Carcinoma of the Breast , Arch Surg 87:457-460 ( (Sept) ) 1963.Crossref 3. Cole, W.H., and Rossiter, L.J.: Chronic Cystic Mastitis: With Particular Reference to Classification , Ann Surg 119:573-590 ( (April) ) 1944.Crossref 4. Foote, F.W., and Stewart, F.W.: Comparative Studies of Cancerous Versus Noncancerous Breasts , Ann Surg 121:6 ( (Jan) ) 1945.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Large Duct Epithelial Hyperplasia and Carcinoma of the Breast

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01340040088017
Publisher site
See Article on Publisher Site

Abstract

Abstract IN A previous study by Humphrey and Swerdlow1 the finding of large duct epithelial hyperplasia in 69% of breasts removed for carcinoma was reported. A similar type of hyperplasia was also present in eight of 14 (64%) benign breast lesions excised 1 to 13 years before the development of carcinoma. On the other hand, only nine of 61 (16%) benign lesions that were diagnosed as fibrocystic disease and in which carcinoma did not develop were found to have large duct epithelial hyperplasia. This method of histologic examination as originally described2 stressed the importance of separating epithelial hyperplasia of large and small ducts. With this strong correlation between large duct epithelial hyperplasia and carcinoma of the breast, a study was initiated to determine, if possible, the natural history of this specific histologic lesion. Methods From records and slides reviewed in the original study, there were 63 breast biopsies performed between 1946 References 1. Humphrey, L.J., and Swerdlow, M.: Relationship of Benign Breast Disease to Carcinoma of the Breast , Surgery 52:841-846 ( (Dec) ) 1962. 2. Swerdlow, M., and Humphrey, L.J.: Fibrocystic Disease and Carcinoma of the Breast , Arch Surg 87:457-460 ( (Sept) ) 1963.Crossref 3. Cole, W.H., and Rossiter, L.J.: Chronic Cystic Mastitis: With Particular Reference to Classification , Ann Surg 119:573-590 ( (April) ) 1944.Crossref 4. Foote, F.W., and Stewart, F.W.: Comparative Studies of Cancerous Versus Noncancerous Breasts , Ann Surg 121:6 ( (Jan) ) 1945.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Oct 1, 1968

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