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New balancing tricks

New balancing tricks HIGHLIGHT S OR G A N O GEN E SI S DEVE L O PM E N TA L B IOL O GY A mean spleen gene The identification of a gene required for the development of a specific vertebrate The secreted signalling molecule Hedgehog organ is a big event in developmental Hh (Hh) was so baptized in Drosophila because biology. With a new mouse knockout, Lu of the effects of its mutation, which turns the et al. have shown that the gene capsulin is ventral surface of the embryo into a lawn of Smo necessary for spleen development. Ptc spiky denticles. Hh was subsequently found Capsulin is a basic helix–loop–helix to belong to a conserved family of secreted (bHLH) transcription factor expressed in signalling molecules, required for growth mesenchymal cells during the early devel- and patterning during animal development. opment of the heart, gut, kidneys and Cellular responses to Hh are controlled by lungs. In the capsulin mutants made by Lu two transmembrane molecules: Patched et al., the initial stages of spleen develop- (Ptc), a multi-pass membrane protein that ment seem normal but the subsequent binds Hh; and Smoothened (Smo), a seven- pass protein that relays the signal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Genetics Springer Journals

New balancing tricks

Casci, Tanita
Nature Reviews Genetics , Volume 1 (1) – Oct 1, 2000
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New balancing tricks

Abstract

HIGHLIGHT S OR G A N O GEN E SI S DEVE L O PM E N TA L B IOL O GY A mean spleen gene The identification of a gene required for the development of a specific vertebrate The secreted signalling molecule Hedgehog organ is a big event in developmental Hh (Hh) was so baptized in Drosophila because biology. With a new mouse knockout, Lu of the effects of its mutation, which turns the et al. have shown that the gene capsulin is ventral surface of the embryo into a lawn of Smo necessary for spleen...
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References (2)

Publisher
Springer Journals
Copyright
Copyright © Macmillan Magazines Ltd. 2000
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1471-0056
eISSN
1471-0064
DOI
10.1038/35049524
Publisher site
See Article on Publisher Site

Abstract

HIGHLIGHT S OR G A N O GEN E SI S DEVE L O PM E N TA L B IOL O GY A mean spleen gene The identification of a gene required for the development of a specific vertebrate The secreted signalling molecule Hedgehog organ is a big event in developmental Hh (Hh) was so baptized in Drosophila because biology. With a new mouse knockout, Lu of the effects of its mutation, which turns the et al. have shown that the gene capsulin is ventral surface of the embryo into a lawn of Smo necessary for spleen development. Ptc spiky denticles. Hh was subsequently found Capsulin is a basic helix–loop–helix to belong to a conserved family of secreted (bHLH) transcription factor expressed in signalling molecules, required for growth mesenchymal cells during the early devel- and patterning during animal development. opment of the heart, gut, kidneys and Cellular responses to Hh are controlled by lungs. In the capsulin mutants made by Lu two transmembrane molecules: Patched et al., the initial stages of spleen develop- (Ptc), a multi-pass membrane protein that ment seem normal but the subsequent binds Hh; and Smoothened (Smo), a seven- pass protein that relays the signal

Journal

Nature Reviews Genetics – Springer Journals

Published: Oct 1, 2000

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