Access the full text.
Sign up today, get DeepDyve free for 14 days.
James Burke, M. Pattoli, K. Gregor, Patrick Brassil, J. Macmaster, K. McIntyre, Xiaoxia Yang, Violetta Iotzova, W. Clarke, J. Strnad, Y. Qiu, F. Zusi (2003)
BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice*The Journal of Biological Chemistry, 278
Fan Yang, Eric Tang, K. Guan, Cun-Yu Wang (2003)
IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide1The Journal of Immunology, 170
M. Neumann, M. Naumann (2007)
Beyond IκBs: alternative regulation of NF‐KB activityThe FASEB Journal, 21
Yinling Hu, V. Baud, M. Delhase, Peilin Zhang, T. Deerinck, Mark Ellisman, R. Johnson, M. Karin (1999)
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB KinaseScience, 284
David Mills, G. Bonizzi, M. Karin, R. Rickert (2007)
Regulation of late B cell differentiation by intrinsic IKKα-dependent signalsProceedings of the National Academy of Sciences, 104
E. Izmailova, N. Paz, Herlen Alencar, Miyoung Chun, L. Schopf, M. Hepperle, Mckenna Lane, G. Harriman, Yajun Xu, T. Ocain, R. Weissleder, U. Mahmood, A. Healy, B. Jaffee (2007)
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.Arthritis and rheumatism, 56 1
D. Rudolph, W. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A. Elia, T. Mak (2000)
Severe liver degeneration and lack of NF - k B activation in NEMO/IKK g -deficient mice
Zhijian Chen, J. Hagler, V. Palombella, F. Melandri, D. Scherer, D. Ballard, T. Maniatis (1995)
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.Genes & development, 9 13
and Baeuerle, T. Henkel (1994)
Function and activation of NF-kappa B in the immune system.Annual review of immunology, 12
S. Ghosh, M. Karin (2002)
Missing Pieces in the NF-κB PuzzleCell, 109
J. DiDonato, Frank Mercurio, Michael Karin (1995)
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa BMolecular and Cellular Biology, 15
K. Ziegelbauer, F. Gantner, N. Lukacs, Aaron Berlin, K. Fuchikami, T. Niki, Katsuya Sakai, H. Inbe, Keisuke Takeshita, M. Ishimori, H. Komura, T. Murata, T. Lowinger, K. Bacon (2005)
A selective novel low‐molecular‐weight inhibitor of IκB kinase‐β (IKK‐β) prevents pulmonary inflammation and shows broad anti‐inflammatory activityBritish Journal of Pharmacology, 145
A. Miagkov, Dmitry Kovalenko, C. Brown, J. Didsbury, J. Cogswell, S. Stimpson, A. Baldwin, S. Makarov (1998)
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint.Proceedings of the National Academy of Sciences of the United States of America, 95 23
J. DiDonato, F. Mercurio, C. Rosette, Wu-Li Jian, H. Suyang, S. Ghosh, M. Karin (1996)
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationMolecular and Cellular Biology, 16
Q. Huynh, N. Kishore, S. Mathialagan, A. Donnelly, C. Tripp (2002)
Kinetic Mechanisms of IκB-related Kinases (IKK) Inducible IKK and TBK-1 Differ from IKK-1/IKK-2 Heterodimer*The Journal of Biological Chemistry, 277
J. Strnad, J. Burke (2007)
IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challengesTrends in Pharmacological Sciences, 28
G. Bonizzi, M. Karin (2004)
The two NF-κB activation pathways and their role in innate and adaptive immunityTrends in Immunology, 25
Ivan Mattioli, A. Sebald, Cyril Bucher, R. Charles, H. Nakano, H. Nakano, T. Doi, M. Kracht, M. Schmitz (2004)
Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import 1The Journal of Immunology, 172
(2011)
of embryonic lethality in
M. Hayden, S. Ghosh (2008)
Shared Principles in NF-κB SignalingCell, 132
G. Ding, P. Fischer, R. Boltz, J. Schmidt, J. Colaianne, A. Gough, R. Rubin, D. Miller (1998)
Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.The Journal of biological chemistry, 273 44
P. Podolin, James Callahan, B. Bolognese, Yue Li, K. Carlson, T. Davis, Geoff Mellor, Christopher Evans, A. Roshak (2005)
Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell ProliferationJournal of Pharmacology and Experimental Therapeutics, 312
H. Sakurai, H. Chiba, H. Miyoshi, T. Sugita, W. Toriumi (1999)
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain*The Journal of Biological Chemistry, 274
A. Beg, W. Sha, R. Bronson, S. Ghosh, D. Baltimore (1995)
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBNature, 376
G. Ding, P. Fischer, R. Boltz, Jack Schmidt, J. Colaianne, A. Gough, R. Rubin, Douglas Miller (1998)
Characterization and Quantitation of NF-κB Nuclear Translocation Induced by Interleukin-1 and Tumor Necrosis Factor-αThe Journal of Biological Chemistry, 273
M. Karin, F. Greten (2005)
NF-κB: linking inflammation and immunity to cancer development and progressionNature Reviews Immunology, 5
K. McIntyre, D. Shuster, Kathleen Gillooly, Donna Dambach, M. Pattoli, P. Lu, Xiadi Zhou, Y. Qiu, F. Zusi, James Burke (2003)
A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.Arthritis and rheumatism, 48 9
Qiutang Li, D. Antwerp, F. Mercurio, Kuo-Fen Lee, I. Verma (1999)
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 GeneScience, 284
Xu Jiang, N. Takahashi, N. Matsui, T. Tetsuka, T. Okamoto (2003)
The NF-κB Activation in Lymphotoxin β Receptor Signaling Depends on the Phosphorylation of p65 at Serine 536*The Journal of Biological Chemistry, 278
M. Graneto, R. Kurumbail, M. Vazquez, H. Shieh, J. Pawlitz, Jennifer Williams, W. Stallings, L. Geng, Ashok Naraian, F. Koszyk, M. Stealey, Xiangdong Xu, R. Weier, G. Hanson, R. Mourey, R. Compton, S. Mnich, G. Anderson, J. Monahan, R. Devraj (2007)
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.Journal of medicinal chemistry, 50 23
Danyi Wen, Y. Nong, Jennifer Morgan, P. Gangurde, A. Bielecki, Jennifer Dasilva, M. Keaveney, Hong Cheng, C. Fraser, L. Schopf, M. Hepperle, G. Harriman, B. Jaffee, T. Ocain, Yajun Xu (2006)
A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast CellsJournal of Pharmacology and Experimental Therapeutics, 317
N. Kishore, Q. Huynh, S. Mathialagan, T. Hall, S. Rouw, D. Creely, G. Lange, J. Caroll, B. Reitz, A. Donnelly, H. Boddupalli, Rodney Combs, K. Kretzmer, C. Tripp (2002)
IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2The Journal of Biological Chemistry, 277
N. Kishore, C. Sommers, S. Mathialagan, J. Guzova, M. Yao, S. Hauser, Khai Huynh, S. Bonar, Cindy Mielke, L. Albee, R. Weier, M. Graneto, C. Hanau, Thao Perry, C. Tripp (2003)
A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts*Journal of Biological Chemistry, 278
G. Mbalaviele, G. Anderson, Amy Jones, P. Ciechi, S. Settle, S. Mnich, M. Thiede, Y. Abu-Amer, J. Portanova, J. Monahan (2006)
Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone DestructionJournal of Pharmacology and Experimental Therapeutics, 317
(1992)
GraFit, Version 4.0, Erithacus Software Ltd., Stanes, UK
S. Tas, J. Adriaansen, N. Hajji, A. Bakker, G. Firestein, M. Vervoordeldonk, P. Tak (2006)
Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.Human gene therapy, 17 8
Zhi-wei Li, W. Chu, Yinling Hu, M. Delhase, T. Deerinck, Mark Ellisman, R. Johnson, M. Karin (1999)
The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of ApoptosisThe Journal of Experimental Medicine, 189
S. Kuiper, L. Joosten, A. Bendele, C. Edwards, O. Arntz, M. Helsen, F. Loo, W. Berg (1998)
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis.Cytokine, 10 9
L. Schopf, A. Savinainen, K. Anderson, J. Kujawa, M. Dupont, Matthew Silva, E. Siebert, S. Chandra, Jennifer Morgan, P. Gangurde, Danyi Wen, Mckenna Lane, Yajun Xu, M. Hepperle, C. HarrimanGeraldine, T. Ocain, B. Jaffee (2006)
IKKβ inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritisArthritis & Rheumatism, 54
M. Karin, A. Lin (2002)
NF-κB at the crossroads of life and deathNature Immunology, 3
D. Rudolph, W. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A. Elia, T. Mak (2000)
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.Genes & development, 14 7
The Journal of Pharmacology and Experimental Therapeutics – Pubmed
Published: Apr 28, 2009
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.