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The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease Shirai et al. show that the glycolytic enzyme PKM2 serves as a molecular integrator of metabolic dysfunction, oxidative stress and tissue inflammation in macrophages from patients with atherosclerotic coronary artery disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Pubmed Central

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

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References (78)

Publisher
Pubmed Central
Copyright
© 2016 Shirai et al.
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.20150900
Publisher site
See Article on Publisher Site

Abstract

Shirai et al. show that the glycolytic enzyme PKM2 serves as a molecular integrator of metabolic dysfunction, oxidative stress and tissue inflammation in macrophages from patients with atherosclerotic coronary artery disease.

Journal

The Journal of Experimental MedicinePubmed Central

Published: Mar 7, 2016

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