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- Publisher
- Wiley
- Copyright
- Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company
- ISSN
- 0741-0395
- eISSN
- 1098-2272
- DOI
- 10.1002/gepi.1370010302
- pmid
- 6544238
- Publisher site
- See Article on Publisher Site
Abstract
A model is presented for the effects of one or two loci, a measured index of the environment and genotype × environment (G×E) interaction of risk for a discontinuous trait. Initial properties of the model are explored for the single locus case, with and without the effects of environment and G×E interaction. Seven data sets were simulated, each comprising 500 nuclear families on whom an environmental index has been measured. Maximum‐likelihood estimation procedures were used to obtain parameter estimates under seven models for each data set. Likelihood ratio tests were constructed, and in all cases it was possible to identify the “correct” model for the simulated data. The matrices of information realized showed that the parameters could be estimated with acceptable precision and that the effects of genes, environment, and G×E interaction could be resolved in the simulated populations. The effects on conventional segregation analysis of ignoring the environment and G×E are considered.
Journal
Genetic Epidemiology – Wiley
Published: Jan 1, 1984
Keywords: genotype × environment interaction; segregation analysis; simulation; nuclear family; likelihood; environmental index; nonadditive