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Simultaneous Chemoradiation in the Treatment of Advanced Head and Neck Cancer

Simultaneous Chemoradiation in the Treatment of Advanced Head and Neck Cancer Abstract • Fifty-eight patients with either advanced or unresectable squamous cell carcinoma of the head and neck were randomly selected to receive either twice daily radiation alone or twice daily radiation plus concomitant chemotherapy with cisplatin and fluorouracil (5-fluorouracil). There was no advantage in survival or time to progression with the addition of chemotherapy to twice daily radiation for patients with advanced resectable cancers. In the group of patients with unresectable cancers, however, there was a statistically significant advantage to the addition of chemotherapy, both in terms of disease-free survival and date to progression. (Arch Otolaryngol Head Neck Surg. 1992;118:806-810) References 1. Murphy GP, ed. Cancer statistics 1991 . CA. 1991;41:8-9, 12. 2. Jacobs JR, Fu KK, Lowry LD, et al. 5-year results of cisplatin and fluorouracil infusion in head and neck cancer . Arch Otolaryngol Head Neck Surg . 1991;117:288-291.Crossref 3. Hong WK, Bromer R. Current concepts: chemotherapy in head and neck cancer . N Engl J Med . 1983;308:75-79.Crossref 4. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data . New York, NY: John Wiley & Sons Inc; 1980. 5. SAS. Statistical Analysis System: User's Guide: Statistics . Cary, NC: SAS Institute; 1985. 6. Becker RA, Chambers JM, Wilks AR. The New S Language . Pacific Grove, Calif: Wadsworth & Brooks/Cole Advanced Books and Software; 1988. 7. Marion J. Chemotherapy and immunotherapy of head and neck tumors . In: Thawley SE, Panje WR, Batsakis JG, Lindberg RD, eds. Comprehensive Management of Head and Neck Tumors . Philadelphia, Pa: WB Saunders Co; 1987:1885-1896. 8. Green MR. Chemotherapy of head and neck cancer . Head Neck Surg . 1978;1:75-86.Crossref 9. Abramowicz M. Drugs of choice for cancer chemotherapy . Med Lett Drugs Ther . 1991;33:21-28. 10. Vokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors . J Clin Oncol . 1990;8:911-934. 11. Taylor SG, Murthy AK, Caldarelli DD, et al. Combined simultaneous cisplatin/fluorouracil chemotherapy and split course radiation in head and neck cancer . J Clin Oncol . 1989;7:846-856. 12. Weissberg JB, Son YH, Papac RJ, et al. Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer . Int J Radiat Oncol Biol Phys . 1989;17:3-9.Crossref 13. Vermund H, Kaalhus O, Winther F, et al. Bleomycin and radiation therapy in squamous cell carcinoma of the upper aero-digestive tract: a phase III clinical trial . Int J Radiat Oncol Biol Phys . 1985;11:1877-1886.Crossref 14. Fu KK, Phillips TL, Silverberg IJ, et al. Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial . J Clin Oncol . 1987;5:1410-1418. 15. Merlano M, Rosso R, Sertoli MR, et al. Randomized comparison of two chemotherapy, radiotherapy schemes for stage III and IV unresectable squamous cell carcinoma of the head and neck . Laryngoscope . 1990;100: 531-535.Crossref 16. Lo TC, Wiley AL, Ansfield FJ, et al. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study . AJR Am J Roentgenol . 1976;126:229-235.Crossref 17. Million RR, Cassisi NJ. General principles for treatment of cancers in the head and neck: radiation therapy . In: Million RR, Cassisi NJ, eds. Management of Head and Neck Cancer: A Multidisciplinary Approach . Philadelphia, Pa: JB Lippincott; 1984:77-90. 18. Wang CC, Blitzer PH, Suit HD. Twice-a-day radiation therapy for cancer of the head and neck . Cancer . 1985;55:2100-2104.Crossref 19. Million RR, Parsons JT, Cassisi NJ. Twice-a-day irradiation technique for squamous cell carcinomas of the head and neck . Cancer . 1985;55:2096-2099.Crossref 20. Corvo R, Merlano M, Looney WB, et al. Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck . Head Neck . 1990;12:60-65.Crossref 21. Sanchiz F, Milla A, Torner J, et al. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer . Int J Radiat Oncol Biol Phys . 1990;19:1347-1350.Crossref 22. Wendt TG, Hartenstein RC, Wustrow TPU, Lissner J. Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: a phase II study . J Clin Oncol . 1989;7:471-476. 23. Muggia FM, Cortes-Funes H, Wasserman TH. Radiotherapy and chemotherapy in combined clinical trials: problems and promise . Int J Radiat Oncol Biol Phys . 1978;4:161-171.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Simultaneous Chemoradiation in the Treatment of Advanced Head and Neck Cancer

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References (25)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1992.01880080028008
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Abstract

Abstract • Fifty-eight patients with either advanced or unresectable squamous cell carcinoma of the head and neck were randomly selected to receive either twice daily radiation alone or twice daily radiation plus concomitant chemotherapy with cisplatin and fluorouracil (5-fluorouracil). There was no advantage in survival or time to progression with the addition of chemotherapy to twice daily radiation for patients with advanced resectable cancers. In the group of patients with unresectable cancers, however, there was a statistically significant advantage to the addition of chemotherapy, both in terms of disease-free survival and date to progression. (Arch Otolaryngol Head Neck Surg. 1992;118:806-810) References 1. Murphy GP, ed. Cancer statistics 1991 . CA. 1991;41:8-9, 12. 2. Jacobs JR, Fu KK, Lowry LD, et al. 5-year results of cisplatin and fluorouracil infusion in head and neck cancer . Arch Otolaryngol Head Neck Surg . 1991;117:288-291.Crossref 3. Hong WK, Bromer R. Current concepts: chemotherapy in head and neck cancer . N Engl J Med . 1983;308:75-79.Crossref 4. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data . New York, NY: John Wiley & Sons Inc; 1980. 5. SAS. Statistical Analysis System: User's Guide: Statistics . Cary, NC: SAS Institute; 1985. 6. Becker RA, Chambers JM, Wilks AR. The New S Language . Pacific Grove, Calif: Wadsworth & Brooks/Cole Advanced Books and Software; 1988. 7. Marion J. Chemotherapy and immunotherapy of head and neck tumors . In: Thawley SE, Panje WR, Batsakis JG, Lindberg RD, eds. Comprehensive Management of Head and Neck Tumors . Philadelphia, Pa: WB Saunders Co; 1987:1885-1896. 8. Green MR. Chemotherapy of head and neck cancer . Head Neck Surg . 1978;1:75-86.Crossref 9. Abramowicz M. Drugs of choice for cancer chemotherapy . Med Lett Drugs Ther . 1991;33:21-28. 10. Vokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors . J Clin Oncol . 1990;8:911-934. 11. Taylor SG, Murthy AK, Caldarelli DD, et al. Combined simultaneous cisplatin/fluorouracil chemotherapy and split course radiation in head and neck cancer . J Clin Oncol . 1989;7:846-856. 12. Weissberg JB, Son YH, Papac RJ, et al. Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer . Int J Radiat Oncol Biol Phys . 1989;17:3-9.Crossref 13. Vermund H, Kaalhus O, Winther F, et al. Bleomycin and radiation therapy in squamous cell carcinoma of the upper aero-digestive tract: a phase III clinical trial . Int J Radiat Oncol Biol Phys . 1985;11:1877-1886.Crossref 14. Fu KK, Phillips TL, Silverberg IJ, et al. Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial . J Clin Oncol . 1987;5:1410-1418. 15. Merlano M, Rosso R, Sertoli MR, et al. Randomized comparison of two chemotherapy, radiotherapy schemes for stage III and IV unresectable squamous cell carcinoma of the head and neck . Laryngoscope . 1990;100: 531-535.Crossref 16. Lo TC, Wiley AL, Ansfield FJ, et al. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study . AJR Am J Roentgenol . 1976;126:229-235.Crossref 17. Million RR, Cassisi NJ. General principles for treatment of cancers in the head and neck: radiation therapy . In: Million RR, Cassisi NJ, eds. Management of Head and Neck Cancer: A Multidisciplinary Approach . Philadelphia, Pa: JB Lippincott; 1984:77-90. 18. Wang CC, Blitzer PH, Suit HD. Twice-a-day radiation therapy for cancer of the head and neck . Cancer . 1985;55:2100-2104.Crossref 19. Million RR, Parsons JT, Cassisi NJ. Twice-a-day irradiation technique for squamous cell carcinomas of the head and neck . Cancer . 1985;55:2096-2099.Crossref 20. Corvo R, Merlano M, Looney WB, et al. Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck . Head Neck . 1990;12:60-65.Crossref 21. Sanchiz F, Milla A, Torner J, et al. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer . Int J Radiat Oncol Biol Phys . 1990;19:1347-1350.Crossref 22. Wendt TG, Hartenstein RC, Wustrow TPU, Lissner J. Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: a phase II study . J Clin Oncol . 1989;7:471-476. 23. Muggia FM, Cortes-Funes H, Wasserman TH. Radiotherapy and chemotherapy in combined clinical trials: problems and promise . Int J Radiat Oncol Biol Phys . 1978;4:161-171.Crossref

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Aug 1, 1992

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