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Interleukin‐18 is High in the Serum of IVF Pregnancies with Ovarian Hyperstimulation Syndrome *

Interleukin‐18 is High in the Serum of IVF Pregnancies with Ovarian Hyperstimulation Syndrome * Problem: The presence of interleukin‐18 (IL‐18) in serum and pre‐ovulatory follicular fluid (FF) and its possible correlation to in‐vitro fertilization/embryo transfer (IVF/ET) outcome and ovarian hyperstimulation syndrome (OHSS) development. Method of study: A prospective study was carried out. Assays for serum and pooled pre‐ovulatory FF levels of IL‐18 were performed on 30 patients who underwent oocyte retrieval for IVF/ET. Results: Mean serum and FF levels of IL‐18 were 370.4 ± 224 and 228.9 ± 208 pg/mL, respectively (r = 0.77, P < 0.0001). Levels of FF IL‐18 were comparable between the two ovaries (right = 221 ± 166.8 pg/mL, left = 237 ± 171.9 pg/mL; r = 0.7550, P = 0.49). A positive correlation was found between IL‐18 FF levels and number of retrieved oocytes (r = 0.45; P = 0.019). In three patients (10%) who developed OHSS, the mean serum level of IL‐18 at day of ovum pickup was significantly higher compared with patients without OHSS (620 ± 196 pg/mL versus 345 ± 251 pg/mL, respectively, P = 0.04). Conclusions: Both pre‐ovulatory FF and serum levels of IL‐18 correlate with the number of retrieved oocytes. The serum IL‐18 level at day of ovum pickup may predict consequent development of OHSS. Further investigations are warranted to determine the role of IL‐18 in the folliculogenesis and OHSS pathogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Reproductive Immunology Wiley

Interleukin‐18 is High in the Serum of IVF Pregnancies with Ovarian Hyperstimulation Syndrome *

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References (19)

Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1046-7408
eISSN
1600-0897
DOI
10.1111/j.1600-0897.2004.00172.x
pmid
15212675
Publisher site
See Article on Publisher Site

Abstract

Problem: The presence of interleukin‐18 (IL‐18) in serum and pre‐ovulatory follicular fluid (FF) and its possible correlation to in‐vitro fertilization/embryo transfer (IVF/ET) outcome and ovarian hyperstimulation syndrome (OHSS) development. Method of study: A prospective study was carried out. Assays for serum and pooled pre‐ovulatory FF levels of IL‐18 were performed on 30 patients who underwent oocyte retrieval for IVF/ET. Results: Mean serum and FF levels of IL‐18 were 370.4 ± 224 and 228.9 ± 208 pg/mL, respectively (r = 0.77, P < 0.0001). Levels of FF IL‐18 were comparable between the two ovaries (right = 221 ± 166.8 pg/mL, left = 237 ± 171.9 pg/mL; r = 0.7550, P = 0.49). A positive correlation was found between IL‐18 FF levels and number of retrieved oocytes (r = 0.45; P = 0.019). In three patients (10%) who developed OHSS, the mean serum level of IL‐18 at day of ovum pickup was significantly higher compared with patients without OHSS (620 ± 196 pg/mL versus 345 ± 251 pg/mL, respectively, P = 0.04). Conclusions: Both pre‐ovulatory FF and serum levels of IL‐18 correlate with the number of retrieved oocytes. The serum IL‐18 level at day of ovum pickup may predict consequent development of OHSS. Further investigations are warranted to determine the role of IL‐18 in the folliculogenesis and OHSS pathogenesis.

Journal

American Journal of Reproductive Immunology – Wiley

Published: May 1, 2004

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