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/lp/karger/plasma-hypoxanthine-concentrations-in-pigs-Ys806MK8kQ
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- Publisher
- Karger
- Copyright
- © 1980 S. Karger AG, Basel
- ISSN
- 0014-312X
- eISSN
- 1421-9921
- DOI
- 10.1159/000128117
- Publisher site
- See Article on Publisher Site
Abstract
Hypoxemia was induced in pigs by artificial ventilation with 7% oxygen. Death occurred after 21–99 min (mean 48 min). The plasma hypoxanthine and base deficit concentrations increased linearly during hypoxemia and were significantly elevated after 5 min compared to initial values. The correlation between hypoxanthine and base deficit was good (p < 0.001, r = 0.68). The rate of increase of plasma hypoxanthine concentration was correlated with survival time and a significant correlation was found between the negative slope of hypoxanthine increase and survival. Death occurred in all animals when the hypoxanthine concentrations exceeded about 125 µmol/l. These findings indicate that the plasma concentration and the rate of increase of hypoxanthine specifically and sensitively reflect tissue hypoxia.
Journal
European Surgical Research – Karger
Published: Jan 1, 1980
Keywords: Free radicals; Hypoxanthine; Hypoxemia; Pigs; Survival