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Passive All-Optical Force Clamp for High-Resolution Laser Trapping

Passive All-Optical Force Clamp for High-Resolution Laser Trapping Optical traps are useful for studying the effects of forces on single molecules. Feedback-based force clamps are often used to maintain a constant load, but the response time of the feedback limits bandwidth and can introduce instability. We developed a novel force clamp that operates without feedback, taking advantage of the anharmonic region of the trapping potential where the differential stiffness vanishes. We demonstrate the utility of such a force clamp by measuring the unfolding of DNA hairpins and the effect of trap stiffness on opening distance and transition rates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physical Review Letters American Physical Society (APS)

Passive All-Optical Force Clamp for High-Resolution Laser Trapping

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Publisher
American Physical Society (APS)
Copyright
Copyright © 2005 The American Physical Society
ISSN
1079-7114
DOI
10.1103/PhysRevLett.95.208102
pmid
16384102
Publisher site
See Article on Publisher Site

Abstract

Optical traps are useful for studying the effects of forces on single molecules. Feedback-based force clamps are often used to maintain a constant load, but the response time of the feedback limits bandwidth and can introduce instability. We developed a novel force clamp that operates without feedback, taking advantage of the anharmonic region of the trapping potential where the differential stiffness vanishes. We demonstrate the utility of such a force clamp by measuring the unfolding of DNA hairpins and the effect of trap stiffness on opening distance and transition rates.

Journal

Physical Review Letters – American Physical Society (APS)

Published: Nov 11, 2005

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