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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature07021
- Publisher site
- See Article on Publisher Site
Abstract
TH17 cells (a subset of interleukin (IL)-17-producing T helper cells) are thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4 T cells. The data demonstrate that transforming growth factor-β (TGF-β) is critical for the differentiation of TH17 cells from highly purified naive CD4+ T cells, but not necessary for induction of IL-17 from committed memory CD4+ T cells.
Journal
Nature – Springer Journals
Published: May 11, 2008