Dabrafenib–trametinib is effective in paediatric high-grade glioma
Abstract
Research highlights Targeted therapy https://doi.org/10.1038/s41571-023-00820-8 Dabrafenib–trametinib is effective in paediatric high-grade glioma Children with recurrent high-grade glioma typically receive combination chemo- therapy, although these regimens pro- vide limited benefit and are highly toxic. Approximately 5–10% of these patients have V600E BRAF -mutant tumours. Now, data from a phase II trial demonstrate the efficacy of the BRAF inhibitor dabrafenib combined with the...