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Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1... The gut microbiota can influence immune-cell function by the production of short-chain fatty acids. Mackay and colleagues show that diets enriched for acetate and butyrate protect non-obese diabetic mice from insulitis and diabetes progression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Immunology Springer Journals

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References (62)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
ISSN
1529-2908
eISSN
1529-2916
DOI
10.1038/ni.3713
Publisher site
See Article on Publisher Site

Abstract

The gut microbiota can influence immune-cell function by the production of short-chain fatty acids. Mackay and colleagues show that diets enriched for acetate and butyrate protect non-obese diabetic mice from insulitis and diabetes progression.

Journal

Nature ImmunologySpringer Journals

Published: Mar 27, 2017

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