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- ISSN
- 1040-8711
- eISSN
- 1531-6963
- DOI
- 10.1097/BOR.0b013e32830aba34
- pmid
- 18698179
- Publisher site
- See Article on Publisher Site
Abstract
Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? a,b b a Carla R. Scanzello , Anna Plaas and Mary K. Crow Hospital for Special Surgery, Division of Purpose of review Rheumatology, New York, New York and Rush Synovial inflammation is increasingly recognized as an important pathophysiologic University Medical Center, Department of Internal Medicine (Rheumatology) and Biochemistry, Chicago, process in osteoarthritis, but the stimuli and downstream pathways activated are not Illinois, USA well defined. Innate immune system activation, best documented in responses to Correspondence to Carla R. Scanzello, Rush University pathogens, likely plays a role in induction of inflammatory mediators and the specific Medical Center, Section of Rheumatology, 1725W cellular infiltrate seen in osteoarthritis. Thus, the Toll-like receptors (TLRs) and their Harrison Street, Suite 1017, Chicago, IL 60612, USA Tel: +1 312 942 8268; fax: +1 312 563 2267; signaling pathways are of particular interest. These innate pattern-recognition receptors e-mail: [email protected] are activated not only by pathogens but by endogenous ‘danger signals’. In this report, we review evidence that certain extracellular matrix components of joint tissues Current Opinion in Rheumatology 2008, (hyaluronan and fibronectin) may act as TLR stimuli, and summarize recent literature 20:565–572 implicating TLR activation
Journal
Current Opinion in Rheumatology – Wolters Kluwer Health
Published: Sep 1, 2008