Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Barretina, B. Taylor, S. Banerji, A. Ramos, M. Lagos‐Quintana, Penelope Decarolis, K. Shah, N. Socci, B. Weir, Alan Ho, Derek Chiang, B. Reva, C. Mermel, G. Getz, Yevgenyi Antipin, R. Beroukhim, John Major, C. Hatton, Richard Nicoletti, M. Hanna, Ted Sharpe, T. Fennell, K. Cibulskis, R. Onofrio, Tsuyoshi Saito, N. Shukla, C. Lau, Sven Nelander, S. Silver, C. Sougnez, A. Viale, W. Winckler, R. Maki, L. Garraway, A. Lash, H. Greulich, D. Root, W. Sellers, G. Schwartz, C. Antonescu, E. Lander, H. Varmus, M. Ladanyi, C. Sander, M. Meyerson, S. Singer (2010)
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapyNature genetics, 42
E. Dombi, A. Baldwin, L. Marcus, M. Fisher, B. Weiss, AeRang Kim, P. Whitcomb, Staci Martin, L. Aschbacher-Smith, T. Rizvi, Jianqiang Wu, Rachel Ershler, P. Wolters, Janet Therrien, J. Glod, J. Belasco, E. Schorry, A. Brofferio, Amy Starosta, A. Gillespie, A. Doyle, N. Ratner, B. Widemann (2016)
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.The New England journal of medicine, 375 26
Theresia Dunzendorfer-Matt, E. Mercado, K. Maly, F. McCormick, K. Scheffzek (2016)
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivationProceedings of the National Academy of Sciences, 113
T. Yuan, Christof Fellmann, Chih-Shia Lee, Cayde Ritchie, V. Thapar, L. Lee, Dennis Hsu, Danielle Grace, Joseph Carver, J. Zuber, Ji Luo, F. McCormick, S. Lowe (2014)
Development of siRNA payloads to target KRAS-mutant cancer.Cancer discovery, 4 10
K. Rauen (2007)
HRAS and the Costello syndromeClinical Genetics, 71
Asaf Maoz, G. Rennert, S. Gruber (2017)
T-Cell Transfer Therapy Targeting Mutant KRAS.The New England journal of medicine, 376 7
B. Willumsen, Annette Christensen, N. Hubbert, A. Papageorge, D. Lowy (1984)
The p21 ras C-terminus is required for transformation and membrane associationNature, 310
J. Settleman, Vikram Narasimhan, L. Foster, R. Weinberg (1992)
Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleusCell, 69
Priyanka Prakash, Yong Zhou, Hong Liang, J. Hancock, A. Gorfe (2016)
Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.Biophysical journal, 110 5
D. Kaplan, D. Morrison, G. Wong, F. McCormick, L. Williams (1990)
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complexCell, 61
Man-Tzu Wang, M. Holderfield, Jacqueline Galeas, R. Delrosario, M. To, A. Balmain, F. McCormick (2015)
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt SignalingCell, 163
J. Downward (2015)
RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?Clinical Cancer Research, 21
Katrin Weise, S. Kapoor, Christian Denter, Jörg Nikolaus, N. Opitz, Sebastian Koch, Gemma Triola, A. Herrmann, H. Waldmann, R. Winter (2011)
Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms.Journal of the American Chemical Society, 133 4
P. Stenson, E. Ball, K. Howells, A. Phillips, M. Mort, D. Cooper (2007)
Human Gene Mutation Database: towards a comprehensive central mutation databaseJournal of Medical Genetics, 45
V. Boyartchuk, M. Ashby, J. Rine (1997)
Modulation of Ras and a-Factor Function by Carboxyl-Terminal ProteolysisScience, 275
M. Milburn, Liang Tong, A. Devos, A. Brunger, Z. Yamaizumi, S. Nishimura, Sung-Hou Kim (1992)
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.Science, 247 4945
Thomas Howard, F. Vazquez, Aviad Tsherniak, A. Hong, M. Rinne, A. Aguirre, J. Boehm, W. Hahn (2016)
Functional Genomic Characterization of Cancer Genomes.Cold Spring Harbor symposia on quantitative biology, 81
A. Stephen, D. Esposito, R. Bagni, F. McCormick (2014)
Dragging ras back in the ring.Cancer cell, 25 3
M. Drosten, Alma Dhawahir, E. Sum, J. Urosevic, C. Lechuga, L. Esteban, E. Castellano, C. Guerra, E. Santos, M. Barbacid (2010)
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survivalThe EMBO Journal, 29
Anchal Chandra, H. Grecco, V. Pisupati, D. Perera, Liam Cassidy, F. Skoulidis, S. Ismail, C. Hedberg, M. Hanzal-Bayer, A. Venkitaraman, A. Wittinghofer, P. Bastiaens (2011)
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteinsNature Cell Biology, 14
Katrin Weise, Gemma Triola, L. Brunsveld, H. Waldmann, R. Winter (2009)
Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains.Journal of the American Chemical Society, 131 4
Chao Zhang, W. Spevak, Ying Zhang, Elizabeth Burton, Yanwen Ma, G. Habets, Jiazhong Zhang, Jacki Lin, T. Ewing, Bernice Matusow, Garson Tsang, A. Marimuthu, Hanna Cho, Guoxiang Wu, Weiru Wang, D. Fong, Hoa Nguyen, S. Shi, P. Womack, Marika Nespi, Rafe Shellooe, Heidi Carias, Ben Powell, E. Light, L. Sanftner, J. Walters, J. Tsai, B. West, G. Visor, Hamid Rezaei, P. Lin, K. Nolop, P. Ibrahim, P. Hirth, G. Bollag (2015)
RAF inhibitors that evade paradoxical MAPK pathway activationNature, 526
A. Kapoor, W. Yao, H. Ying, S. Hua, Alison Liewen, Qiuyun Wang, Y. Zhong, Changli Wu, A. Sadanandam, A. Sadanandam, Baoli Hu, Q. Chang, Gerald Chu, R. Al-Khalil, Shan Jiang, Hong’ai Xia, Eliot Fletcher-Sananikone, Carol Lim, Gillian Horwitz, A. Viale, P. Pettazzoni, Nora Sanchez, Huamin Wang, A. Protopopov, Jianhua Zhang, T. Heffernan, Randy Johnson, L. Chin, Y. Wang, G. Draetta, R. DePinho (2014)
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic CancerCell, 158
T. Maurer, L. Garrenton, A. Oh, Keith Pitts, Daniel Anderson, N. Skelton, B. Fauber, B. Pan, S. Malek, D. Stokoe, M. Ludlam, K. Bowman, Jiansheng Wu, A. Giannetti, M. Starovasnik, I. Mellman, P. Jackson, J. Rudolph, Weiru Wang, G. Fang (2012)
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activityProceedings of the National Academy of Sciences, 109
K. Keppler-Noreuil, V. Parker, T. Darling, J. Martinez-Agosto (2016)
Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategiesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, 172
Rand Arafeh, N. Qutob, Rafi Emmanuel, A. Keren-Paz, J. Madore, A. Elkahloun, J. Wilmott, J. Gartner, A. Pizio, S. Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, K. Dutton-Regester, P. Johansson, A. Pritchard, N. Waddell, Victoria Hill, Jimmy Lin, Yael Hevroni, S. Rosenberg, Javed Khan, S. Ben-Dor, M. Niv, I. Ulitsky, G. Mann, R. Scolyer, N. Hayward, Yardena Samuels (2015)
Recurrent inactivating RASA2 mutations in melanomaNature genetics, 47
E. Castellano, J. Downward (2011)
RAS Interaction with PI3K: More Than Just Another Effector Pathway.Genes & cancer, 2 3
M. Burns, Qi Sun, R. Daniels, DeMarco Camper, J. Kennedy, J. Phan, E. Olejniczak, Taekyu Lee, A. Waterson, O. Rossanese, S. Fesik (2014)
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeProceedings of the National Academy of Sciences, 111
M. Ahmadian, P. Stege, K. Scheffzek, A. Wittinghofer (1997)
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of RasNature Structural Biology, 4
Catherine Huntley, A. Hodder, M. Ramachandran (2015)
Clinical and historical aspects of the Elephant Man: exploring the facts and the myths.Gene, 555 1
M. Murillo, S. Zelenay, E. Nye, E. Castellano, F. Lassailly, G. Stamp, J. Downward (2014)
RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.The Journal of clinical investigation, 124 8
E. Ferro, L. Trabalzini (2010)
RalGDS family members couple Ras to Ral signalling and that's not all.Cellular signalling, 22 12
Yong Zhou, J. Hancock (2015)
Ras nanoclusters: Versatile lipid-based signaling platforms.Biochimica et biophysica acta, 1853 4
Benjamin Sperlich, S. Kapoor, H. Waldmann, R. Winter, Katrin Weise (2016)
Regulation of K-Ras4B Membrane Binding by Calmodulin.Biophysical journal, 111 1
Dharmaiah (2016)
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδProc. Natl. Acad. Sci. USA, 113
M. Trahey, F. McCormick (1987)
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.Science, 238 4826
Diane Shao, W. Xue, E. Krall, A. Bhutkar, F. Piccioni, Xiaoxing Wang, Anna Schinzel, S. Sood, Joseph Rosenbluh, Jong Kim, Yaara Zwang, T. Roberts, D. Root, T. Jacks, W. Hahn (2014)
KRAS and YAP1 Converge to Regulate EMT and Tumor SurvivalCell, 158
I. Chio, S. Jafarnejad, M. Ponz-Sarvisé, Youngkyu Park, Keith Rivera, Wilhelm Palm, John Wilson, V. Sangar, Yuan Hao, D. Öhlund, K. Wright, D. Filippini, E. Lee, Brandon Silva, C. Schoepfer, J. Wilkinson, J. Buscaglia, G. DeNicola, Hervé Tiriac, Molly Hammell, H. Crawford, E. Schmidt, C. Thompson, D. Pappin, N. Sonenberg, D. Tuveson (2016)
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic CancerCell, 166
L. Gutiérrez, A. Magee, C. Marshall, J. Hancock (1989)
Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.The EMBO Journal, 8
Kevin Boyd, Liyan Gao, Rui Feng, M. Beasley, L. Messiaen, B. Korf, A. Theos (2010)
Phenotypic variability among café-au-lait macules in neurofibromatosis type 1.Journal of the American Academy of Dermatology, 63 3
S. Ekvall, L. Hagenäs, J. Allanson, G. Annéren, M. Bondeson (2011)
Co‐occurring SHOC2 and PTPN11 mutations in a patient with severe/complex Noonan syndrome‐like phenotypeAmerican Journal of Medical Genetics Part A, 155
Tim Wang, Haiyan Yu, Nicholas Hughes, Bingxu Liu, Arek Kendirli, K. Klein, Walter Chen, E. Lander, D. Sabatini (2017)
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic RasCell, 168
T. Bivona, Steven Quatela, Brian Bodemann, Ian Ahearn, M. Soskis, A. Mor, John Miura, Heidi Wiener, Latasha Wright, Shahryar Saba, Duke Yim, Adam Fein, I. Castro, Chi Li, C. Thompson, A. Cox, M. Philips (2006)
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.Molecular cell, 21 4
Russell Spencer-Smith, A. Koide, Yong Zhou, Raphael Eguchi, F. Sha, P. Gajwani, Dianicha Santana, Ankit Gupta, Miranda Jacobs, Erika Herrero-García, Jacqueline Cobbert, H. Lavoie, Matthew Smith, T. Rajakulendran, Evan Dowdell, M. Okur, I. Dementieva, F. Sicheri, M. Therrien, J. Hancock, M. Ikura, S. Koide, J. O’Bryan (2017)
Inhibition of RAS function through targeting an allosteric regulatory site.Nature chemical biology, 13 1
C. Der (2008)
Faculty Opinions recommendation of Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Yong Zhou, Priyanka Prakash, Hong Liang, Kwang-jin Cho, A. Gorfe, J. Hancock (2017)
Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal OutputCell, 168
Surbhi Gupta, A. Ramjaun, P. Haiko, Yihua Wang, P. Warne, B. Nicke, E. Nye, G. Stamp, K. Alitalo, J. Downward (2007)
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in MiceCell, 129
Peter Westcott, Kyle Halliwill, M. To, Mamunur Rashid, A. Rust, Thomas Keane, R. Delrosario, Kuang-Yu Jen, K. Gurley, C. Kemp, E. Fredlund, D. Quigley, D. Adams, A. Balmain (2014)
The mutational landscapes of genetic and chemical models of Kras-driven lung cancerNature, 517
M. Krauthammer, Y. Kong, Antonella Bacchiocchi, Perry Evans, Natapol Pornputtapong, Cen Wu, Jamie McCusker, Shuangge Ma, E. Cheng, R. Straub, M. Serin, M. Bosenberg, S. Ariyan, D. Narayan, M. Sznol, H. Kluger, S. Mane, J. Schlessinger, R. Lifton, R. Halaban (2015)
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomasNature Genetics, 47
M. Holderfield, Marian Deuker, F. McCormick, M. McMahon (2014)
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyondNature Reviews Cancer, 14
Tiffany Chang, Kimberly Krisman, Emily Theobald, Jin Xu, Jon Akutagawa, Jennifer Lauchle, S. Kogan, B. Braun, K. Shannon (2013)
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.The Journal of clinical investigation, 123 1
J. Ostrem, K. Shokat (2016)
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based designNature Reviews Drug Discovery, 15
J. Raaijmakers, J. Bos (2009)
Specificity in Ras and Rap Signaling*Journal of Biological Chemistry, 284
H. Brems, M. Chmara, M. Sahbatou, E. Denayer, K. Taniguchi, Reiko Kato, R. Somers, L. Messiaen, S. Schepper, J. Fryns, J. Cools, P. Marynen, G. Thomas, A. Yoshimura, E. Legius (2007)
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotypeNature Genetics, 39
S. Edkins, S. O’Meara, A. Parker, C. Stevens, M. Reis, Siân Jones, C. Greenman, H. Davies, G. Dalgliesh, S. Forbes, C. Hunter, Raffaella Smith, P. Stephens, P. Goldstraw, A. Nicholson, T. Chan, V. Velculescu, S. Yuen, S. Leung, M. Stratton, P. Futreal (2006)
Recurrent KRAS codon 146 mutations in human colorectal cancerCancer Biology & Therapy, 5
Blanca Alvarez-Moya, Cristina López-Alcalá, M. Drosten, O. Bachs, N. Agell (2010)
K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and functionOncogene, 29
S. Powers (1992)
Genetic analysis of ras homologs in yeasts.Seminars in cancer biology, 3 4
K. Scheffzek, M. Ahmadian, W. Kabsch, L. Wiesmüller, A. Lautwein, F. Schmitz, A. Wittinghofer (1997)
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.Science, 277 5324
Rosenberg (2017)
T-cell transfer therapy targeting mutant KRASN. Engl. J. Med., 376
D. Whyte, P. Kirschmeier, Tish Hockenberry, Irma Nunez-Oliva, L. James, J. Catino, W. Bishop, J. Pai (1997)
K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors*The Journal of Biological Chemistry, 272
Priyanka Prakash, A. Sayyed-Ahmad, A. Gorfe (2015)
pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound ProteinsPLoS Computational Biology, 11
Lauren McGillicuddy, Jody Fromm, Pablo Hollstein, Sara Kubek, R. Beroukhim, T. Raedt, Bryan Johnson, S. Williams, P. Nghiemphu, L. Liau, T. Cloughesy, P. Mischel, A. Parret, J. Seiler, G. Moldenhauer, K. Scheffzek, A. Stemmer-Rachamimov, C. Sawyers, C. Brennan, L. Messiaen, I. Mellinghoff, K. Cichowski (2009)
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.Cancer cell, 16 1
V. Williams, Philip Cohen, D. Stewart (2011)
Sorafenib‐induced premalignant and malignant skin lesionsInternational Journal of Dermatology, 50
G. Martin, David Viskoohil, G. Bollag, P. McCabe, W. Crosier, H. Haubruck, L. Conroy, R. Clark, P. O’Connell, R. Cawthon, M. Innis, F. McCormick (1990)
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21Cell, 63
M. Pacold, S. Suire, O. Perisic, S. Lara-González, C. Davis, E. Walker, P. Hawkins, L. Stephens, J. Eccleston, Roger Williams (2000)
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γCell, 103
Erin Higgins, J. Bos, J. Ackerman, H. Mason-Suares, C. MacRae, K. Sol‐Church, K. Gripp, R. Urrutia, Michael Ackerman (2016)
Abstract 18770: Elucidation of MRAS-Mediated Noonan Syndrome With Cardiac HypertrophyCirculation, 134
P. Bayrak-Toydemir, D. Stevenson (2016)
RASA1-Related Disorders
Si-Yu Zhang, Benjamin Sperlich, Fang-Yi Li, Samy Al-Ayoubi, Hong-Xue Chen, Yu-Fen Zhao, Yan‐Mei Li, Katrin Weise, R. Winter, Yong-Xiang Chen (2017)
Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B.ACS chemical biology, 12 6
M. García-Romero, P. Parkin, I. Lara-Corrales (2016)
Mosaic Neurofibromatosis Type 1: A Systematic ReviewPediatric Dermatology, 33
M. To, C. Wong, A. Karnezis, R. Rosario, R. Lauro, A. Balmain (2008)
Kras regulatory elements and exon 4A determine mutation specificity in lung cancerNature Genetics, 40
Nallathambi Jeyabalan, J. Clement (2016)
SYNGAP1: Mind the GapFrontiers in Cellular Neuroscience, 10
M. Quinlan, Steven Quatela, M. Philips, J. Settleman (2008)
Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell ExpansionMolecular and Cellular Biology, 28
N. Kohl, Charles Omer, Michael Conner, Neville Anthony, Joseph Davide, S. Desolms, Elizabeth Giuliani, Robert Gomez, Samuel Graham, K. Hamilton, Laurence Handt, George Hartman, K. Koblan, A. Kral, Patricia Miller, S. Mosser, T. O’Neill, E. Rands, M. Schaber, Jackson Gibbs, A. Oliff (1995)
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic miceNature Medicine, 1
C. Thiel, M. Wilken, M. Zenker, H. Sticht, R. Fahsold, G. Gusek-Schneider, A. Rauch (2009)
Independent NF1 and PTPN11 mutations in a family with neurofibromatosis‐Noonan syndromeAmerican Journal of Medical Genetics Part A, 149A
Jin Xu, K. Haigis, Ari Firestone, Megan McNerney, Qing Li, E. Davis, Shann-Ching Chen, J. Nakitandwe, J. Downing, T. Jacks, M. Beau, K. Shannon (2013)
Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.Cancer discovery, 3 9
Stephanie Morris, M. Acosta, S. Garg, Jonathan Green, S. Huson, E. Legius, K. North, Jonathan Payne, E. Plasschaert, T. Frazier, L. Weiss, Yi Zhang, D. Gutmann, J. Constantino (2016)
Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT).JAMA psychiatry, 73 12
C. Brennan, H. Momota, D. Hambardzumyan, T. Ozawa, A. Tandon, Alicia Pedraza, E. Holland (2009)
Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic AlterationsPLoS ONE, 4
Sathiya Dharmaiah, Lakshman Bindu, Peter Frank, W. Gillette, D. Esposito, D. Nissley, F. McCormick, A. Stephen, D. Simanshu (2016)
Abstract 4373: Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδCancer Research, 76
P. Boriack-Sjodin, S. Margarit, D. Bar-Sagi, J. Kuriyan (1998)
The structural basis of the activation of Ras by SosNature, 394
J. Güldenhaupt, T. Rudack, P. Bachler, D. Mann, Gemma Triola, H. Waldmann, C. Kötting, K. Gerwert (2012)
N-Ras forms dimers at POPC membranes.Biophysical journal, 103 7
J. Min, A. Zaslavsky, Giuseppe Fedele, S. McLaughlin, Elizabeth Reczek, T. Raedt, Isil Guney, David Strochlic, L. Macconaill, R. Beroukhim, R. Bronson, S. Ryeom, W. Hahn, M. Loda, K. Cichowski (2010)
An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κBNature Medicine, 16
M. Patricelli, M. Janes, Lian-Sheng Li, R. Hansen, U. Peters, L. Kessler, YuChing Chen, Jeff Kucharski, Jun Feng, T. Ely, Jeffrey Chen, Sarah Firdaus, Anjali Babbar, Pingda Ren, Yi Liu (2016)
Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.Cancer discovery, 6 3
Elda Grabocka, Y. Pylayeva-Gupta, M. Jones, Veronica Lubkov, Eyoel Yemanaberhan, L. Taylor, Hao-Hsuan Jeng, D. Bar-Sagi (2014)
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.Cancer cell, 25 2
Priam Villalonga, Cristina López-Alcalá, M. Bosch, A. Chiloeches, N. Rocamora, Joan Gil, R. Marais, C. Marshall, O. Bachs, N. Agell (2001)
Calmodulin Binds to K-Ras, but Not to H- or N-Ras, and Modulates Its Downstream SignalingMolecular and Cellular Biology, 21
I. Vetter, A. Wittinghofer (2001)
The Guanine Nucleotide-Binding Switch in Three DimensionsScience, 294
Björn Papke, Sandip Murarka, H. Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina Truxius, E. Fansa, S. Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Saabi, M. Baumann, P. Nussbaumer, A. Wittinghofer, H. Waldmann, P. Bastiaens (2016)
Identification of pyrazolopyridazinones as PDEδ inhibitorsNature Communications, 7
D. Lake, Sonia Correˆa, J. Mu¨ller
The University of Bradford Institutional Repository
Hyunbum Jang, A. Banerjee, T. Chavan, Shaoyong Lu, Jian Zhang, V. Gaponenko, R. Nussinov (2016)
The higher level of complexity of K‐Ras4B activation at the membraneThe FASEB Journal, 30
M. Mazhab-Jafari, C. Marshall, Matthew Smith, G. Gasmi-Seabrook, P. Stathopulos, F. Inagaki, L. Kay, B. Neel, M. Ikura (2015)
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding siteProceedings of the National Academy of Sciences, 112
Hong-Fu Li, Zhi-Ying Wu (2016)
Genotype-phenotype correlations of amyotrophic lateral sclerosisTranslational Neurodegeneration, 5
P. Rodriguez-Viciana, Celine Sabatier, F. McCormick (2004)
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They RegulateMolecular and Cellular Biology, 24
J. Hancock, A. Magee, J. Childs, C. Marshall (1989)
All ras proteins are polyisoprenylated but only some are palmitoylatedCell, 57
A. Brasil, A. Pereira, Luciana Wanderley, C. Kim, A. Malaquias, A. Jorge, J. Krieger, D. Bertola (2010)
PTPN11 and KRAS gene analysis in patients with Noonan and Noonan-like syndromes.Genetic testing and molecular biomarkers, 14 3
Alexander Vogel, Guido Reuther, Katrin Weise, Gemma Triola, Jörg Nikolaus, Kui‐Thong Tan, C. Nowak, A. Herrmann, H. Waldmann, R. Winter, D. Huster (2009)
The lipid modifications of Ras that sense membrane environments and induce local enrichment.Angewandte Chemie, 48 46
M. Fivaz, T. Meyer (2005)
Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulinThe Journal of Cell Biology, 170
J. Hunter, A. Manandhar, M. Carrasco, D. Gurbani, S. Gondi, K. Westover (2015)
Biochemical and Structural Analysis of Common Cancer-Associated KRAS MutationsMolecular Cancer Research, 13
Higgins (2017)
Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophyJCI Insight, 2
Wan-Chen Lin, L. Iversen, Hsiung-Lin Tu, C. Rhodes, Sune Christensen, J. Iwig, Scott Hansen, William Huang, J. Groves (2014)
H-Ras forms dimers on membrane surfaces via a protein–protein interfaceProceedings of the National Academy of Sciences, 111
Suzanne Schubbert, M. Zenker, Sara Rowe, Silke Böll, C. Klein, G. Bollag, I. Burgt, L. Musante, V. Kalscheuer, L. Wehner, Hoa Nguyen, B. West, Kam Zhang, E. Sistermans, A. Rauch, C. Niemeyer, K. Shannon, C. Kratz (2006)
Germline KRAS mutations cause Noonan syndromeNature Genetics, 38
Haigis (2008)
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colonNat. Genet., 40
S. Athuluri-Divakar, Rodrigo Vasquez-Del Carpio, K. Dutta, S. Baker, S. Cosenza, I. Basu, Y. Gupta, M. Reddy, Lynn Ueno, J. Hart, P. Vogt, D. Mulholland, C. Guha, A. Aggarwal, Elala Reddy (2016)
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block SignalingCell, 165
J. Cherfils, M. Zeghouf (2013)
Regulation of small GTPases by GEFs, GAPs, and GDIs.Physiological reviews, 93 1
C. Mignot, C. Stülpnagel, C. Nava, D. Ville, D. Sanlaville, D. Sanlaville, G. Lesca, G. Lesca, Agnès Rastetter, B. Gachet, Y. Marie, Christoph Korenke, I. Borggraefe, Dorota Hoffmann-Zacharska, E. Szczepanik, Mariola Rudzka-Dybała, U. Yiş, H. Caglayan, A. Isapof, I. Marey, E. Panagiotakaki, C. Korff, E. Rossier, A. Riess, Stefanie Beck-Woedl, A. Rauch, C. Zweier, Juliane Hoyer, A. Reis, M. Mironov, M. Bobylova, K. Mukhin, L. Hernández-Hernández, B. Maher, S. Sisodiya, M. Kuhn, D. Glaeser, Sarah Wechuysen, Candace Myers, H. Mefford, K. Hörtnagel, S. Biskup, J. Lemke, D. Heron, G. Kluger, C. Depienne (2016)
Genetic and neurodevelopmental spectrum of SYNGAP1-associated intellectual disability and epilepsyJournal of Medical Genetics, 53
E. Bruin, C. Cowell, P. Warne, M. Jiang, R. Saunders, M. Melnick, S. Gettinger, Zenta Walther, A. Wurtz, Guus Heynen, D. Heideman, J. Gómez-Román, A. García-Castaño, Y. Gong, M. Ladanyi, H. Varmus, R. Bernards, E. Smit, K. Politi, J. Downward (2014)
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.Cancer discovery, 4 5
Viviana Cordeddu, E. Schiavi, L. Pennacchio, Avi Ma’ayan, A. Sarkozy, V. Fodale, S. Cecchetti, A. Cardinale, Joel Martin, Wendy Schackwitz, A. Lipzen, G. Zampino, L. Mazzanti, M. Digilio, S. Martinelli, E. Flex, F. Lepri, D. Bartholdi, K. Kutsche, G. Ferrero, C. Anichini, A. Selicorni, C. Rossi, R. Tenconi, M. Zenker, D. Merlo, B. Dallapiccola, R. Iyengar, P. Bazzicalupo, B. Gelb, M. Tartaglia (2009)
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hairNature genetics, 41
K. Gripp, K. Aldinger, James Bennett, L. Baker, Jessica Tusi, N. Powell-Hamilton, D. Stabley, K. Sol‐Church, A. Timms, W. Dobyns (2016)
A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hairAmerican Journal of Medical Genetics Part A, 170
C. Rowell, J. Kowalczyk, M. Lewis, Ana García (1997)
Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo *The Journal of Biological Chemistry, 272
Q. Dai, E. Choy, V. Chiu, J. Romano, S. Slivka, Susan Steitz, S. Michaelis, M. Philips (1998)
Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum*The Journal of Biological Chemistry, 273
S. Leevers, H. Paterson, C. Marshall (1994)
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membraneNature, 369
Nelli Erwin, Benjamin Sperlich, Guillaume Garivet, H. Waldmann, Katrin Weise, R. Winter (2016)
Lipoprotein insertion into membranes of various complexity: lipid sorting, interfacial adsorption and protein clustering.Physical chemistry chemical physics : PCCP, 18 13
Xiaolin Nan, Tanja Tamgüney, E. Collisson, Li-jung Lin, C. Pitt, Jacqueline Galeas, Sophia Lewis, J. Gray, F. McCormick, S. Chu (2015)
Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathwayProceedings of the National Academy of Sciences, 112
L. Young, N. Hartig, Marta Muñoz-Alegre, J. Oses-Prieto, Sevi Durdu, S. Bender, V. Vijayakumar, Matteo Rudan, C. Gewinner, S. Henderson, Amit Jathoul, Rupinder Ghatrora, M. Lythgoe, A. Burlingame, P. Rodriguez-Viciana (2013)
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.Molecular cell, 52 5
Malte Schmick, N. Vartak, Björn Papke, Marija Kovacevic, Dina Truxius, Lisaweta Rossmannek, P. Bastiaens (2014)
KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular TransportCell, 157
E. Castellano, Clare Sheridan, M. Thin, E. Nye, B. Spencer‐Dene, M. Diefenbacher, C. Moore, Madhu Kumar, M. Murillo, E. Grönroos, F. Lassailly, G. Stamp, J. Downward (2013)
Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor MaintenanceCancer Cell, 24
J. Ostrem, U. Peters, M. Sos, J. Wells, K. Shokat (2013)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactionsNature, 503
Gangfeng Xu, B. Lin, Kazuma Tanaka, D. Dunn, D. Wood, R. Gesteland, Raymond White, R. Weiss, F. Tamanoi (1990)
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiaeCell, 63
J. Jackson, C. Cochrane, J. Bourne, P. Solski, J. Buss, C. Der (1990)
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.Proceedings of the National Academy of Sciences of the United States of America, 87
Priyanka Prakash, A. Gorfe (2017)
Membrane orientation dynamics of lipid-modified small GTPasesSmall GTPases, 8
M. To, R. Rosario, Peter Westcott, Karl Banta, A. Balmain (2012)
Interactions Between Wildtype and Mutant Ras Genes in Lung and Skin CarcinogenesisOncogene, 32
R. Bremner, A. Balmain (1990)
Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7Cell, 61
D. Stokoe, S. Macdonald, K. Cadwallader, M. Symons, J. Hancock (1994)
Activation of Raf as a result of recruitment to the plasma membrane.Science, 264 5164
Y. Aoki, T. Niihori, Shin-ichi Inoue, Y. Matsubara (2015)
Recent advances in RASopathiesJournal of Human Genetics, 61
(2017)
NIFTP Accounts for Over Half of "Carcinomas" Harboring RAS Mutations
S. McLaughlin, S. Olsen, Benjamin Dake, T. Raedt, E. Lim, R. Bronson, R. Beroukhim, K. Polyak, Myles Brown, C. Kuperwasser, K. Cichowski (2013)
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.Cancer cell, 24 3
S. Kapoor, Katrin Weise, M. Erlkamp, Gemma Triola, H. Waldmann, R. Winter (2012)
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interactionEuropean Biophysics Journal, 41
Yiguang Zhu, Jinxin Xu, Xiangui Mei, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu, Jinsong Liu, Changsheng Zhang (2016)
Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis.ACS chemical biology, 11 4
R. Lobell, Dongming Liu, C. Buser, J. Davide, E. Depuy, K. Hamilton, K. Koblan, Yih Lee, S. Mosser, S. Motzel, J. Abbruzzese, C. Fuchs, E. Rowinsky, E. Rubin, Sunil Sharma, P. Deutsch, K. Mazina, B. Morrison, L. Wildonger, S. Yao, N. Kohl (2002)
Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.Molecular cancer therapeutics, 1 9
J. Swarthout, S. Lobo, L. Farh, M. Croke, W. Greentree, R. Deschenes, M. Linder (2005)
DHHC9 and GCP16 Constitute a Human Protein Fatty Acyltransferase with Specificity for H- and N-Ras*Journal of Biological Chemistry, 280
E. Uusitalo, Matti Rantanen, R. Kallionpää, M. Pöyhönen, Jussi Leppävirta, H. Ylä-Outinen, V. Riccardi, E. Pukkala, J. Pitkäniemi, S. Peltonen, J. Peltonen (2016)
Distinctive Cancer Associations in Patients With Neurofibromatosis Type 1.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 34 17
Gunther Zimmermann, Björn Papke, S. Ismail, N. Vartak, Anchal Chandra, M. Hoffmann, S. Hahn, Gemma Triola, A. Wittinghofer, P. Bastiaens, H. Waldmann (2013)
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signallingNature, 497
Daniel Ritt, M. Abreu-Blanco, Lakshman Bindu, David Durrant, Ming Zhou, Suzanne Specht, A. Stephen, M. Holderfield, D. Morrison (2016)
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.Molecular cell, 64 5
Y. Ohba, N. Mochizuki, Shigeko Yamashita, A. Chan, J. Schrader, S. Hattori, K. Nagashima, M. Matsuda (2000)
Regulatory Proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3*The Journal of Biological Chemistry, 275
Vera Paulson, Priyanka Shivdasani, Trevor Angell, E. Cibas, J. Krane, N. Lindeman, E. Alexander, J. Barletta (2017)
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Accounts for More Than Half of "Carcinomas" Harboring RAS Mutations.Thyroid : official journal of the American Thyroid Association, 27 4
Jimi Kim, E. McMillan, Hyun Kim, Niranjan Venkateswaran, Gurbani Makkar, J. Rodriguez-Canales, P. Villalobos, J. Neggers, Saurabh Mendiratta, Shuguang Wei, Y. Landesman, W. Senapedis, E. Baloglu, C. Chow, Robin Frink, B. Gao, M. Roth, J. Minna, D. Daelemans, I. Wistuba, B. Posner, P. Scaglioni, M. White (2016)
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancerNature, 538
K. Inouye, S. Mizutani, H. Koide, Y. Kaziro (2000)
Formation of the Ras Dimer Is Essential for Raf-1 Activation*The Journal of Biological Chemistry, 275
Roymarie Ballester, Mark FurthQ, Ora RosenQll (1987)
Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.The Journal of biological chemistry, 262 6
Joshua Campbell, A. Alexandrov, Jaegil Kim, J. Wala, A. Berger, C. Pedamallu, S. Shukla, Guangwu Guo, Angela Brooks, Bradley Murray, M. Imieliński, Xin Hu, Shiyun Ling, Rehan Akbani, Mara Rosenberg, C. Cibulskis, A. Ramachandran, E. Collisson, D. Kwiatkowski, M. Lawrence, J. Weinstein, R. Verhaak, Catherine Wu, P. Hammerman, A. Cherniack, G. Getz, Jean T, J. Zenklusen, J. Zhang, Ina Felau, John Demchok, Liming Yang, Zhining Wang, M. Ferguson, R. Tarnuzzer, C. Hutter, H. Sofia, T. Pihl, Yunhu Wan, Sudha Chudamani, Jia Liu, Charlie Sun, R. Naresh, Laxmi Lolla, Ye Wu, C. Creighton, W. Rathmell, J. Auman, S. Balu, T. Bodenheimer, D. Hayes, K. Hoadley, A. Hoyle, Corbin Jones, S. Jefferys, S. Meng, P. Mieczkowski, Lisle Mose, C. Perou, J. Roach, Yan Shi, J. Simons, Tara Skelly, Matthew Soloway, Donghui Tan, Junyuan Wu, Umadevi Veluvolu, J. Parker, M. Wilkerson, L. Boice, Mei Huang, L. Thorne, M. Noble, Hailei Zhang, David Heiman, Juok Cho, Nils Gehlenborg, G. Saksena, Douglas Voet, Pei Lin, S. Frazer, L. Chin, M. Tsao, F. Allison, D. Chadwick, T. Muley, M. Meister, H. Dienemann, R. Kucherlapati, Peter Park, Jay Bowen, J. Gastier-Foster, M. Gerken, K. Leraas, T. Lichtenberg, N. Ramirez, L. Wise, E. Zmuda, Josh Stuart, E. Collisson, M. Peifer, D. Kwiatkowski, Joshua Campbell, C. Sougnez, S. Schumacher, J. Shih, R. Beroukhim, Travis Zack, S. Gabriel, Matthew Meyerson, L. Byers, Tanja Davidsen, P. Laird, D. Weisenberger, D. Berg, Moiz Bootwalla, Phillip Lai, D. Maglinte, S. Baylin, J. Herman, Ludmila Danilova, L. Cope, D. Crain, Erin Curley, J. Gardner, Kevin Lau, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, M. Sherman, P. Yena, G. Mills, M. Artyomov, R. Schreiber, R. Govindan, Matthew Meyerson (2016)
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomasNature genetics, 48
S. Olsen, A. Wronski, Z. Castaño, Benjamin Dake, Clare Malone, T. Raedt, Miriam Enos, Yoko Derose, Wenhui Zhou, S. Guerra, M. Loda, A. Welm, A. Partridge, S. McAllister, C. Kuperwasser, K. Cichowski (2017)
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.Cancer discovery, 7 2
E. Pai, W. Kabsch, U. Krengel, K. Holmes, J. John, A. Wittinghofer (1989)
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformationNature, 341
Lake (2016)
Negative feedback regulation of the ERK1/2 MAPK pathwayCell. Mol. Life Sci., 73
Alyson Freeman, Daniel Ritt, D. Morrison (2013)
The importance of Raf dimerization in cell signalingSmall GTPases, 4
Irma Stowe, E. Mercado, Timothy Stowe, Erika Bell, J. Oses-Prieto, Hilda Hernandez, A. Burlingame, F. McCormick (2012)
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.Genes & development, 26 13
J. Bos, H. Rehmann, A. Wittinghofer (2007)
GEFs and GAPs: Critical Elements in the Control of Small G ProteinsCell, 129
W. Tidyman, K. Rauen (2016)
Pathogenetics of the RASopathies.Human molecular genetics, 25 R2
A. Brasil, A. Malaquias, Luciana Wanderley, C. Kim, J. Krieger, A. Jorge, A. Pereira, D. Bertola (2010)
Co-occurring PTPN11 and SOS1 gene mutations in Noonan syndrome: does this predict a more severe phenotype?Arquivos brasileiros de endocrinologia e metabologia, 54 8
D. Easton, M. Ponder, S. Huson, B. Ponder (1993)
An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes.American journal of human genetics, 53 2
P. Rodriguez-Viciana, J. Oses-Prieto, A. Burlingame, M. Fried, F. McCormick (2006)
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.Molecular cell, 22 2
Pamela Sung, Frederick Tsai, H. Vais, Helen Court, Jun Yang, Nicole Fehrenbacher, J. Foskett, M. Philips (2013)
Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptorsProceedings of the National Academy of Sciences, 110
H. Mott, D. Owen (2015)
Structures of Ras superfamily effector complexes: What have we learnt in two decades?Critical Reviews in Biochemistry and Molecular Biology, 50
Jay Lusk, V. Lam, N. Tolwinski (2017)
Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding CancerCancers, 9
M. Ullrich, M. Weber, Antonia Post, Antonia Post, Sandy Popp, J. Grein, M. Zechner, H. González, A. Kreis, Angelika Schmitt, Nurcan Üçeyler, Klaus‐Peter Lesch, Klaus‐Peter Lesch, K. Schuh (2017)
OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiencyMolecular Psychiatry, 23
D. Abankwa, A. Gorfe, Kerry Inder, J. Hancock (2010)
Ras membrane orientation and nanodomain localization generate isoform diversityProceedings of the National Academy of Sciences, 107
B. Rotblat, I. Prior, C. Muncke, R. Parton, Y. Kloog, Y. Henis, J. Hancock (2004)
Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma MembraneMolecular and Cellular Biology, 24
Walter Jessen, Shyra Miller, E. Jousma, Jianqiang Wu, T. Rizvi, M. Brundage, D. Eaves, B. Widemann, Mi-Ok Kim, E. Dombi, J. Sabo, Atira Dudley, M. Niwa-Kawakita, G. Page, M. Giovannini, B. Aronow, T. Cripe, N. Ratner (2013)
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.The Journal of clinical investigation, 123 1
A. Bernards (2003)
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila.Biochimica et biophysica acta, 1603 2
J. Hancock, K. Cadwallader, C. Marshall (1991)
Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K‐ras(B).The EMBO Journal, 10
A. Shain, M. Garrido, T. Botton, Eric Talevich, I. Yeh, J. Sanborn, Jongsuk Chung, Nicholas Wang, H. Kakavand, G. Mann, J. Thompson, J. Thompson, T. Wiesner, R. Roy, A. Olshen, A. Gagnon, J. Gray, Nam Huh, Joe Hur, K. Busam, R. Scolyer, R. Scolyer, R. Cho, R. Murali, B. Bastian (2015)
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathwayNature genetics, 47
Qi Sun, Jason Burke, J. Phan, M. Burns, E. Olejniczak, A. Waterson, Taekyu Lee, O. Rossanese, S. Fesik (2012)
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.Angewandte Chemie, 51 25
Zhongqiu Zhang, Yian Wang, H. Vikis, L. Johnson, Gongjie Liu, Jie Li, Marshall Anderson, R. Sills, H. Hong, T. Devereux, T. Jacks, K. Guan, M. You (2001)
Wildtype Kras2 can inhibit lung carcinogenesis in miceNature Genetics, 29
Yuan Xiong, Jia Lu, J. Hunter, Lianbo Li, D. Scott, H. Choi, S. Lim, A. Manandhar, S. Gondi, Taebo Sim, K. Westover, N. Gray (2017)
Covalent Guanosine Mimetic Inhibitors of G12C KRAS.ACS medicinal chemistry letters, 8 1
Amy Young, David Lou, F. McCormick (2013)
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.Cancer discovery, 3 1
Cell – Unpaywall
Published: Jun 1, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.