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PERMEABILITY IN ACUTE EXPERIMENTAL INFLAMMATORY ŒDEMA

PERMEABILITY IN ACUTE EXPERIMENTAL INFLAMMATORY ŒDEMA Book Reviews 373 clinicians and well for the future of in physiology among practising augurs British a of the medicine. It is also, unfortunately, symptom present separation between clinical physiology and many in British Medical Schools. professional physiologists The reviewer the contents as accurate as is in such found possible simplified The rather synoptic chapters. elementary level of presentation is more than justified if it is aimed at a wide audience. The reviewer like to have seen would, however, a little more of the intellectual excitement in applying to what phvsiological knowledge Sir Robert Platt in a foreword describes as subtle of nature as witnessed experiments at the bedside". This should be the real message of such books as this. It would be invidious to are compare the quality of various chapters, as they all but The book sound and relatively unambitious, making simple clear reading. is too elementary to be clinical but should used by even the youngest investigator, be read at least once by every student or clinician feels that young general who his physiological knowledge in relation to disease is wanting. K. W. DONALD. PERMEABILITY IN ACUTE EXPERIMENTAL CEDEMA. INFLAMMATORY E. KELEMEN. Budapest: Hungarian Academy of Sciences. 1960. Pp. 256. By 42s. This book has some excellent features. The binding, and paper layout are of outstanding quality, the translation is there are references a good, copious indicating vivid interest what in is going on in medical science throughout the world and the dedication is admirable, being to "the anonymous librarian". Yet at the end one is left at the wondering somewhat inconclusive results of so much experimental work and extensive This scholarship. is the more surprising since the experimental basis of the argument would seem to be and sound secure. The primary observation is that injection of bovine testicular extract into the hind-pads of rats is followed by a local cedema which may be suppressed by the administration of salicylate. This phenomenon is studied in relation to adrenalectomy, hypophysectomy, the administra- tion of adrenal and other hormones, fluid and electrolyte balance, metabolism and a variety of local factors. From all this the author's main conclusion is that per- meability changes as evidenced by the production or suppression of cedema are not explicable in physico-chemical terms but are an active cellular phenomenon involving capillary endothelium and "the tissue cell membrane ". No distinction is made between vascular and tissue permeability. The principle factors affecting per- meability are the amount of energy rich material brought to a particular site and the capacity of the cells there to combust it. The arguments leading to these conclusions are not easy to follow and it is not entirely clear why the author places such emphasis on this metabolic hypothesis, interesting though it is. One reason for dissatisfaction with this book is that the principle phenomenon has been used more as an indicator than as something which itself needs explanation. The generalized conception of permeability put forward is entirely unacceptable to this reviewer as is also the rather muddled identification of permeability with swelling. T. D. DAY. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Physiology Wiley

PERMEABILITY IN ACUTE EXPERIMENTAL INFLAMMATORY ŒDEMA

Day, T. D.
Experimental Physiology , Volume 45 (4) – Oct 10, 1960
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Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0958-0670
eISSN
1469-445X
DOI
10.1113/expphysiol.1960.sp001495
Publisher site
See Article on Publisher Site

Abstract

Book Reviews 373 clinicians and well for the future of in physiology among practising augurs British a of the medicine. It is also, unfortunately, symptom present separation between clinical physiology and many in British Medical Schools. professional physiologists The reviewer the contents as accurate as is in such found possible simplified The rather synoptic chapters. elementary level of presentation is more than justified if it is aimed at a wide audience. The reviewer like to have seen would, however, a little more of the intellectual excitement in applying to what phvsiological knowledge Sir Robert Platt in a foreword describes as subtle of nature as witnessed experiments at the bedside". This should be the real message of such books as this. It would be invidious to are compare the quality of various chapters, as they all but The book sound and relatively unambitious, making simple clear reading. is too elementary to be clinical but should used by even the youngest investigator, be read at least once by every student or clinician feels that young general who his physiological knowledge in relation to disease is wanting. K. W. DONALD. PERMEABILITY IN ACUTE EXPERIMENTAL CEDEMA. INFLAMMATORY E. KELEMEN. Budapest: Hungarian Academy of Sciences. 1960. Pp. 256. By 42s. This book has some excellent features. The binding, and paper layout are of outstanding quality, the translation is there are references a good, copious indicating vivid interest what in is going on in medical science throughout the world and the dedication is admirable, being to "the anonymous librarian". Yet at the end one is left at the wondering somewhat inconclusive results of so much experimental work and extensive This scholarship. is the more surprising since the experimental basis of the argument would seem to be and sound secure. The primary observation is that injection of bovine testicular extract into the hind-pads of rats is followed by a local cedema which may be suppressed by the administration of salicylate. This phenomenon is studied in relation to adrenalectomy, hypophysectomy, the administra- tion of adrenal and other hormones, fluid and electrolyte balance, metabolism and a variety of local factors. From all this the author's main conclusion is that per- meability changes as evidenced by the production or suppression of cedema are not explicable in physico-chemical terms but are an active cellular phenomenon involving capillary endothelium and "the tissue cell membrane ". No distinction is made between vascular and tissue permeability. The principle factors affecting per- meability are the amount of energy rich material brought to a particular site and the capacity of the cells there to combust it. The arguments leading to these conclusions are not easy to follow and it is not entirely clear why the author places such emphasis on this metabolic hypothesis, interesting though it is. One reason for dissatisfaction with this book is that the principle phenomenon has been used more as an indicator than as something which itself needs explanation. The generalized conception of permeability put forward is entirely unacceptable to this reviewer as is also the rather muddled identification of permeability with swelling. T. D. DAY.

Journal

Experimental Physiology – Wiley

Published: Oct 10, 1960

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