Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

High melatonin solubility in aqueous medium

High melatonin solubility in aqueous medium Shida CS, Castrucci AML, Lamy‐Freund MT. High melatonin solubility in aqueous medium. J Pineal Res. 1994:16:198–201. The pineal hormone melatonin (5‐methoxy‐N‐acetyl‐tryptamine) has been reported to participate in important physiological processes. Although some of its biological actions seem to depend on a protein receptor at the membrane surface, melatonin is known to interact with a large variety of tissues and cells, suggesting that the molecule may not necessarily interact through a specific membrane receptor at a specific cell. Most discussions of melatonin activity have assumed that the molecule is highly hydrophobic. Contrary to belief, the present work shows that melatonin is soluble in a purely aqueous medium up to 5 ± 10‐3 M and describes a new method of melatonin preparation which shows the high hydrophilicity of the molecule. The results presented will affect the current biological hypothesis on the need of a melatonin carrier in the blood stream or the mechanisms which allow the hormone to cross the cell membrane and interact at the level of the nucleus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pineal Research Wiley

High melatonin solubility in aqueous medium

Download PDF
4 pages

Loading next page...
 
/lp/wiley/high-melatonin-solubility-in-aqueous-medium-aJXqolzbhc

References (19)

Publisher
Wiley
Copyright
Copyright © 1994 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0742-3098
eISSN
1600-079X
DOI
10.1111/j.1600-079X.1994.tb00102.x
Publisher site
See Article on Publisher Site

Abstract

Shida CS, Castrucci AML, Lamy‐Freund MT. High melatonin solubility in aqueous medium. J Pineal Res. 1994:16:198–201. The pineal hormone melatonin (5‐methoxy‐N‐acetyl‐tryptamine) has been reported to participate in important physiological processes. Although some of its biological actions seem to depend on a protein receptor at the membrane surface, melatonin is known to interact with a large variety of tissues and cells, suggesting that the molecule may not necessarily interact through a specific membrane receptor at a specific cell. Most discussions of melatonin activity have assumed that the molecule is highly hydrophobic. Contrary to belief, the present work shows that melatonin is soluble in a purely aqueous medium up to 5 ± 10‐3 M and describes a new method of melatonin preparation which shows the high hydrophilicity of the molecule. The results presented will affect the current biological hypothesis on the need of a melatonin carrier in the blood stream or the mechanisms which allow the hormone to cross the cell membrane and interact at the level of the nucleus.

Journal

Journal of Pineal Research – Wiley

Published: May 1, 1994

There are no references for this article.