Abstract

The Correlation Between Linkage Disequilibrium and Distance: Implications for Recombination in Hominid Mitochondria var callbackToken='50581F413BDA517'; var gAuthTimeStamp = '2015-11-23T03:45:26.704-08:00'; var gSessionId = '@vdQi1pj7H1e8h3grj8gYA'; var gAuthzRequired = 'false'; var gAuthnMethods1 = ''; var gAuthnMethods2 = ''; var gAuthnIPs = ''; var gAuthnIndividuals = ''; var gAuthnInstitutions = ''; MathJax.Hub.Config({ tex2jax: { inlineMath: (("$","$"),("\\(","\\)")), processClass: "tex2jax_process|mathjax" } }); MathJax.Hub.Queue(function() { gColTempResize = true; fixColHeights(1); gColTempResize = false; }); var siqDOI = encodeURIComponent(""); var siqIsOpenAccess = encodeURIComponent(""); var siqPubDate = encodeURIComponent("20011101"); if (siqDOI.length == 0) { siqDOI = "UNKNOWN"; } if (gAuthnIndividuals.length != 0) { if (gAuthnInstitutions.length != 0) { authnEntity = encodeURIComponent(gAuthnIndividuals + ',' + gAuthnInstitutions); } else { authnEntity = encodeURIComponent(gAuthnIndividuals); } } else { authnEntity = encodeURIComponent(gAuthnInstitutions); } var commonString = 'authSessionId=' + gSessionId + String.fromCharCode(0x26) + 'authzRequired=' + gAuthzRequired + String.fromCharCode(0x26) + 'authentication_method=' + encodeURIComponent(gAuthnMethods2) + String.fromCharCode(0x26) + 'authnIPs=' + gAuthnIPs + String.fromCharCode(0x26) + 'authnInstitutions=' + authnEntity; var gPageId = "pageid-content"; var gVariant = "extract"; // Not completely done var eventType = "extract"; var accessType; if (siqIsOpenAccess == 'true') { accessType = 'SOA'; } else { accessType = 'subscription'; } var NTPT_PGEXTRA = commonString + String.fromCharCode(0x26) + 'event_type=' + eventType + String.fromCharCode(0x26) + 'publication_date=' + siqPubDate + String.fromCharCode(0x26) + 'access_type=' + accessType + String.fromCharCode(0x26) + 'doi=' + siqDOI ; // alert("NTPT_PGEXTRA is " + NTPT_PGEXTRA); We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more Skip Navigation Oxford Journals Contact Us My Basket My Account Molecular Biology and Evolution About This Journal Contact This Journal Subscriptions View Current Issue (Volume 32 Issue 12 December 2015) Archive Search Oxford Journals Medicine & Health Science & Mathematics Molecular Biology and Evolution Volume 18 Issue 11 Pp. 2132-2135. The Correlation Between Linkage Disequilibrium and Distance: Implications for Recombination in Hominid Mitochondria Julien Meunier and Adam Eyre-Walker Ecole Normale Superieure de Lyon, Lyon, France; Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton, England Accepted July 16, 2001. It is generally believed that the mitochondrial genome is inherited from a single parent in animals and higher plants and that the inheritance of mitochondrial DNA (mtDNA) is therefore clonal (Birky 1995 <$REFLINK> ). However, the clonality of human mtDNA has recently been questioned (Awadalla, Eyre-Walker, and Maynard Smith 1999 <$REFLINK> ; Eyre-Walker, Smith, and Maynard Smith 1999 a <$REFLINK> ; Hagelberg et al. 1999 <$REFLINK> ) and keenly debated (Eyre-Walker, Smith, and Maynard Smith 1999 b <$REFLINK> ; Macaulay, Richards, and Sykes 1999 <$REFLINK> ; Awadalla, Eyre-Walker, and Maynard Smith 2000 <$REFLINK> ; Eyre-Walker 2000 <$REFLINK> ; Jorde and Bamshad 2000 <$REFLINK> ; Kivisilid and Villems 2000 <$REFLINK> ; Kumar et al. 2000 <$REFLINK> ; Parsons and Irwin 2000 <$REFLINK> ). The evidence of recombination in human mtDNA comes from two sources. First, many phylogenetic trees constructed using mtDNA contain a large amount of homoplasy (e.g., Vigilant et al. 1991 <$REFLINK> ; Ingman et al. 2000 <$REFLINK> ), which has generally been attributed to the presence of hypervariable sites in the mtDNA (Hasegawa et al. 1993 <$REFLINK> ; Wakeley 1993 <$REFLINK> ). However, Eyre-Walker, Smith, and Maynard Smith (1999 a, 1999 b ) <$REFLINK> have suggested that the homoplasies could be due to recombination. Second, Awadalla, Eyre-Walker, and Maynard Smith (1999) <$REFLINK> found that linkage disequilibrium (LD) declined as a function of the distance between sites in several human data sets and one chimpanzee mtDNA data set, a pattern which is highly consistent with recombination. However, their analysis was criticized on several grounds. In particular, Jorde and Bamshad (2000) <$REFLINK> and Kumar et al. (2000) <$REFLINK> argued that the measure of LD used by Awadalla, Eyre-Walker, and Maynard Smith (1999) <$REFLINK> , r 2 , the squared correlation of allele frequencies (Hill and Robertson 1968 <$REFLINK> ), was inappropriate … (Full Text of this Article) « Previous | Next Article » Table of Contents This Article Mol Biol Evol (2001) 18 (11): 2132-2135. » Extract Free Full Text (HTML) Full Text (PDF) Classifications Letter Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Meunier, J. Articles by Eyre-Walker, A. Search for related content PubMed PubMed citation Articles by Meunier, J. Articles by Eyre-Walker, A. 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