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/lp/bioscientifica/molecular-mechanisms-by-which-hormones-and-cytokines-regulate-cell-b8dCFzd0WH
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- Publisher
- Bioscientifica
- Copyright
- © 2009 Society for Endocrinology
- ISSN
- 0952-5041
- eISSN
- 1479-6813
- DOI
- 10.1677/JME-08-0174
- pmid
- 19273571
- Publisher site
- See Article on Publisher Site
Abstract
Hormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomoleculesexert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesisis to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium.The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium fromthe basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. Thisreview will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforminggrowth factor-βs and tumor necrosis factor-α) on cell junction restructuring in the testis and the molecular mechanisms.
Journal
Journal of Molecular Endocrinology – Bioscientifica
Published: Aug 1, 2009