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Pharmacological investigations on a central synapse operated by acetylcholine

Pharmacological investigations on a central synapse operated by acetylcholine J. Physiol. (I956) 13I, 154-I69 PHARMACOLOGICAL INVESTIGATIONS ON A CENTRAL SYNAPSE OPERATED BY ACETYLCHOLINE By J. C. ECCLES, ROSAMOND M. ECCLES AND P. FATT Department of Physiology, Australian National University, Canberra, Australia (Received 13 June 1955) Recently it has been shown that impulses in the motor-axon collaterals synaptically excite a special of group interneurones (called Renshaw cells) lying in the ventro-medial region of the ventral horn of the spinal cord (Eccles, Fatt & Koketsu, 1954). It would be expected that synaptic transmission from these collaterals of motor axons would be mediated by the same transmitter substance that operates at the peripheral neuro-muscular junctions of these motor axons, i.e. by acetylcholine, and pharmacological investigation con- firmed this in expectation. However, some respects the pharmacological findings display anomalies: for example dihydro-,B-erythroidine was a powerful whereas was blocking agent, D-tubocurarine ineffective; in contrast to such anticholinesterases as eserine and TEPP, prostigmine was found to be virtually ineffective; finally there was a large variation in the excitatory action pro- duced by intra-arterial injections of acetylcholine. The present paper gives an account of further pharmacological investigations which have been performed on this synaptic mechanism in an attempt to account for these anomalies, and also http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Pharmacological investigations on a central synapse operated by acetylcholine

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References (23)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1956.sp005452
Publisher site
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Abstract

J. Physiol. (I956) 13I, 154-I69 PHARMACOLOGICAL INVESTIGATIONS ON A CENTRAL SYNAPSE OPERATED BY ACETYLCHOLINE By J. C. ECCLES, ROSAMOND M. ECCLES AND P. FATT Department of Physiology, Australian National University, Canberra, Australia (Received 13 June 1955) Recently it has been shown that impulses in the motor-axon collaterals synaptically excite a special of group interneurones (called Renshaw cells) lying in the ventro-medial region of the ventral horn of the spinal cord (Eccles, Fatt & Koketsu, 1954). It would be expected that synaptic transmission from these collaterals of motor axons would be mediated by the same transmitter substance that operates at the peripheral neuro-muscular junctions of these motor axons, i.e. by acetylcholine, and pharmacological investigation con- firmed this in expectation. However, some respects the pharmacological findings display anomalies: for example dihydro-,B-erythroidine was a powerful whereas was blocking agent, D-tubocurarine ineffective; in contrast to such anticholinesterases as eserine and TEPP, prostigmine was found to be virtually ineffective; finally there was a large variation in the excitatory action pro- duced by intra-arterial injections of acetylcholine. The present paper gives an account of further pharmacological investigations which have been performed on this synaptic mechanism in an attempt to account for these anomalies, and also

Journal

The Journal of Physiology – Wiley

Published: Jan 27, 1956

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