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CHAPTER VI: CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL FAILURE, WITH PARTICULAR REFERENCE TO THE EFFECT OF lα‐HYDROXYVITAMIN D3

CHAPTER VI: CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL... CHAPTER VI CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL FAILURE, WITH PARTICU- LAR REFERENCE TO THE EFFECT OF la-HYDROXYVITAMIN D3 The most common clinical features related to calcium and phosphate metabolism in chronic renal failure include bone pain, myopathy, severe pruritus and symptoms due to metastatic calcification. The clinical manifestations and the effect of treatment with la(OH)D3 will be described separately for each of these symptoms. Bone pain: Although abnormal blood biochemistry and evidence of renal osteodys- trophy is present in the majority of uremic patients (see Chapter I1 and V) bone pain is present rather infrequently. In a series of 195 dialysis and non-dialysis patients bone pain was present in only 3 (183), while in another study 4227) bone pain was found in 2 of 15 CFtF-patients with overt hyperparathyroidism. Coburn et al. (89) found 34 of 47 patients investigated and bone pain was clinical symptoms in the predominant finding in 28 of the patients. However, in their study patients were selected (for later treatment with 1.25(OH)2D3) on the basis of bone biopsies and blood biochemistry. In 88 Danish consecu- tive CFtF-patients (215) pain related to the bones was present in 7 (8%) cases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Internal Medicine Wiley

CHAPTER VI: CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL FAILURE, WITH PARTICULAR REFERENCE TO THE EFFECT OF lα‐HYDROXYVITAMIN D3

Journal of Internal Medicine , Volume 207 (S638) – Dec 12, 1980
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Publisher
Wiley
Copyright
"Copyright © 1980 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
0954-6820
eISSN
1365-2796
DOI
10.1111/j.0954-6820.1980.tb12851.x
Publisher site
See Article on Publisher Site

Abstract

CHAPTER VI CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL FAILURE, WITH PARTICU- LAR REFERENCE TO THE EFFECT OF la-HYDROXYVITAMIN D3 The most common clinical features related to calcium and phosphate metabolism in chronic renal failure include bone pain, myopathy, severe pruritus and symptoms due to metastatic calcification. The clinical manifestations and the effect of treatment with la(OH)D3 will be described separately for each of these symptoms. Bone pain: Although abnormal blood biochemistry and evidence of renal osteodys- trophy is present in the majority of uremic patients (see Chapter I1 and V) bone pain is present rather infrequently. In a series of 195 dialysis and non-dialysis patients bone pain was present in only 3 (183), while in another study 4227) bone pain was found in 2 of 15 CFtF-patients with overt hyperparathyroidism. Coburn et al. (89) found 34 of 47 patients investigated and bone pain was clinical symptoms in the predominant finding in 28 of the patients. However, in their study patients were selected (for later treatment with 1.25(OH)2D3) on the basis of bone biopsies and blood biochemistry. In 88 Danish consecu- tive CFtF-patients (215) pain related to the bones was present in 7 (8%) cases.

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Journal of Internal Medicine – Wiley

Published: Dec 12, 1980

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