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Appendix A. Skin biopsy of the left calf taken during flare-up shows a slight epidermic atrophy with a lymphocytary infiltrate. Moreover, a mixed infiltrate with perivascular lymphocytes and abundant dermic eosinophils can be observed. In the center of the biopsy a subcorneal pustule constituted by polymorphonuclears, eosinophils and neutrophils can be seen (Hematoxilin-Eosin stain; original magnification x10, x40 respectively). Appendix B Appendix C J Investig Allergol Clin Immunol 2022; Vol. 32(1) © 2021 Esmon Publicidad doi: 10.18176/jiaci.0709 2 Table 1. Reported non-immediate reactions due to alendronate with allergological study. Clinical Latency Author(s) Sex, age Allergological study with alendronate presentation period Patch test 20%, 10%, 1%, 0.1% pet. - Negative Kimura Red papules Scratch patch tests 1%, 0.1% pet. - Negative F, 72 10 days et al. [1] and petechiae Scratch patch tests 20%, 10% pet. - Positive LTT – Positive Patch test (scratch-chamber) 50% pet., wat. -Positive* Brinkmeier Maculopapular F, 60 4 months Open test (rub, prick, scratch) - Negative et al. [2] skin lesions OCT - Positive CASE 1 Erythematous Patch test 1% pet. - Positive M, 70 rush Patch test 1%, 0.1% wat. - Positive Barrantes Desquamative et al. [3] CASE 2 - Patch tests - Negative
Journal of Investigational Allergology and Clinical Immunology – Unpaywall
Published: Feb 21, 2022
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