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GAPs in growth factor signalling

GAPs in growth factor signalling Approximately 2% of genes predicted by the sequenced human genome encode small GTPases and their regulators, highlighting the biological significance of regulated GTPase activity. Among the key GTPase regulators are the GTPase activating proteins (GAPs), which function to down-modulate active GTPases. Of the numerous identified GAPs, several have been implicated in signal transduction downstream of growth factors. In particular, GAPs for the Ras and Rho GTPases, which mediate a variety of receptor-transduced signals, appear to play an essential role in growth factor dependent GTPase regulation. Experimental studies of several of the GAPs have begun to elucidate mechanisms by which GAP activity is influenced by growth factor signaling, including direct phosphorylation, sub-cellular redistribution and protein degradation. Here, some of these mechanisms of GAP regulation in the context of signaling responses to growth factors are reviewed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Growth Factors Taylor & Francis

GAPs in growth factor signalling

Bernards, Andre; Settleman, Jeffrey
Growth Factors , Volume 23 (2): 7 – Jun 1, 2005
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References (38)

Publisher
Taylor & Francis
Copyright
© 2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
ISSN
1029-2292
eISSN
0879-7194
DOI
10.1080/08977190500130480
pmid
16019436
Publisher site
See Article on Publisher Site

Abstract

Approximately 2% of genes predicted by the sequenced human genome encode small GTPases and their regulators, highlighting the biological significance of regulated GTPase activity. Among the key GTPase regulators are the GTPase activating proteins (GAPs), which function to down-modulate active GTPases. Of the numerous identified GAPs, several have been implicated in signal transduction downstream of growth factors. In particular, GAPs for the Ras and Rho GTPases, which mediate a variety of receptor-transduced signals, appear to play an essential role in growth factor dependent GTPase regulation. Experimental studies of several of the GAPs have begun to elucidate mechanisms by which GAP activity is influenced by growth factor signaling, including direct phosphorylation, sub-cellular redistribution and protein degradation. Here, some of these mechanisms of GAP regulation in the context of signaling responses to growth factors are reviewed.

Journal

Growth Factors – Taylor & Francis

Published: Jun 1, 2005

Keywords: Growth factors; GTPase activating proteins; signal transduction; GTPase regulation

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