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References (136)
-
Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening
-
(2022)
Pathway network of pyroptosis and its potential inhibitors in acute kidney injury, 175
-
Structure of the human ATP synthase
-
Endothelial FAM3A positively regulates post-ischaemic angiogenesis
-
TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme
-
KLF4 regulates FAM3A to promotes angiotensin II-induced proliferation and migration of vascular smooth muscle cells through the PI3K/AKT signaling pathway
-
(2021)
Global epidemiology of stroke and access to acute ischemic stroke interventions, 97
-
FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis
-
(2025)
Liver ischemia reperfusion injury: mechanisms, cellular pathways, and therapeutic approaches, 150
-
(2023)
The Ninj1/Dusp1 axis contributes to liver ischemia reperfusion injury by regulating macrophage activation and neutrophil infiltration, 15
-
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
-
(2023)
FAM3A ameliorates brain impairment induced by hypoxia-ischemia in neonatal rat, 43
-
(2022)
Coronary In-stent restenosis: JACC state-of-the-art review, 80
-
(2016)
Transfer of mitochondria from astrocytes to neurons after stroke, 535
-
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage
-
(2018)
ROS-induced HepG2 cell death from hyperthermia using magnetic hydroxyapatite nanoparticles, 29
-
FAM3A Deficiency − Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure
-
(2024)
In-stent restenosis: is the future bioresorbable?, 17
-
Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death
-
(2024)
Time to rename the “ischemia/reperfusion injury” model to “ischemia/delayed reperfusion injury” model?, 9
-
Regulation of NLRPs by reactive oxygen species: A story of crosstalk
-
ROS-induced HepG2 cell death from hyperthermia using magnetic hydroxyapatite nanoparticles
-
UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles
-
Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2)
-
PPARγ Mediates Protective Effect against Hepatic Ischemia/Reperfusion Injury via NF-κB Pathway
-
Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity
-
(2022)
Regulatory mechanisms and environmental adaptation of the F-ATPase family, 45
-
(2022)
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress, 113
-
Time to rename the “ischemia/reperfusion injury” model to “ischemia/delayed reperfusion injury” model?
-
(2023)
FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase, 139
-
China stroke surveillance report 2021
-
FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat
-
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination
-
Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: Preclinical evidences with therapeutic approaches
-
FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury
-
The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke
-
An overview of ATP synthase, inhibitors, and their toxicity
-
Regulatory Mechanisms and Environmental Adaptation of the F-ATPase Family
-
The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity
-
(2023)
Pyroptosis in cardiovascular diseases: pumping gasdermin on the fire, 69
-
(2023)
Mitochondrial quality control in health and cardiovascular diseases, 11
-
DDIT3/CHOP promotes LPS/ATP-induced pyroptosis in osteoblasts via mitophagy inhibition
-
(2024)
The SWELL1 channel promotes ischemic brain damage by mediating neuronal swelling and glutamate toxicity, 11
-
Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model
-
(2016)
FAM3A attenuates ER stress-induced mitochondrial dysfunction and apoptosis via CHOP-Wnt pathway, 94
-
Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
-
(2011)
Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2), 343
-
(2023)
Mechanisms of cadmium neurotoxicity, 24
-
(2019)
TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme, 33
-
(2024)
Mitochondria in the central nervous System in health and disease: the puzzle of the therapeutic potential of mitochondrial transplantation, 13
-
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts
-
(2022)
Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death, 13
-
(2024)
Regulation of NLRPs by reactive oxygen species: a story of crosstalk, 1871
-
(2019)
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration, 10
-
(2020)
Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: preclinical evidences with therapeutic approaches, 885
-
VEGF stimulated the angiogenesis by promoting the mitochondrial functions
-
(2024)
UCP2, a member of the mitochondrial uncoupling proteins: an overview from physiological to pathological roles, 12
-
(2024)
FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury, 74
-
(2023)
Targeting mitochondrial shape: at the heart of cardioprotection, 118
-
Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury
-
NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway
-
Mitochondrial quality control in health and cardiovascular diseases
-
(2022)
Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity, 19
-
FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury
-
Rosuvastatin alleviated the liver ischemia reperfusion injury by activating the expression of peroxisome proliferator-activated receptor gamma (PPARγ)
-
(2018)
Targeted upregulation of uncoupling protein 2 within the basal ganglia output structure ameliorates dyskinesia after severe liver failure, 124
-
(2024)
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage, 121
-
(2023)
Glial cells response in stroke, 43
-
(2023)
Acute kidney injury and distant organ dysfunction-network system analysis, 103
-
Pathway network of pyroptosis and its potential inhibitors in acute kidney injury
-
(2021)
Rosuvastatin alleviated the liver ischemia reperfusion injury by activating the expression of peroxisome proliferator-activated receptor gamma (PPARγ), 53
-
(2018)
FAM3 gene family: a promising therapeutical target for NAFLD and type 2 diabetes, 81
-
(2024)
DDIT3/CHOP promotes LPS/ATP-induced pyroptosis in osteoblasts via mitophagy inhibition, 1871
-
Liver ischemia reperfusion injury: Mechanisms, cellular pathways, and therapeutic approaches
-
FAM3A is a target gene of peroxisome proliferator-activated receptor gamma
-
Targeting mitochondrial shape: at the heart of cardioprotection
-
(2023)
Structure of the human ATP synthase, 83
-
(2019)
Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model, 10
-
(2021)
Mitochondrial uncoupling proteins (UCPs) as key modulators of ROS homeostasis: a crosstalk between diabesity and male infertility?, 10
-
Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions
-
(2002)
Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria, 1555
-
Coronary In-Stent Restenosis
-
(2014)
FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis, 59
-
(2022)
Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway, 12
-
The global perspective on peroxisome proliferator-activated receptor γ (PPARγ) in ectopic fat deposition: A review
-
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire
-
In-Stent Restenosis
-
The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration
-
(2024)
FAM3A deficiency - induced mitochondrial dysfunction underlies post-infarct mortality and heart failure, 17
-
Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1
-
(2017)
NFE2 induces miR-423-5p to promote gluconeogenesis and hyperglycemia by repressing the hepatic FAM3A-ATP-Akt pathway, 66
-
(2023)
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy, 13
-
(2020)
Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury, 24
-
(2019)
Vascular endothelial growth factor biology for regenerative angiogenesis, 149
-
(2025)
KLF4 regulates FAM3A to promotes angiotensin II-induced proliferation and migration of vascular smooth muscle cells through the PI3K/AKT signaling pathway, 187
-
(2017)
FAM3A mediates PPARγ’s protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress, 8
-
Acute kidney injury and distant organ dysfunction-network system analysis
-
(2013)
FAM3A is a target gene of peroxisome proliferator-activated receptor gamma, 1830
-
FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes
-
(2023)
China stroke surveillance report 2021, 10
-
Transfer of mitochondria from astrocytes to neurons after stroke
-
(2023)
The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke, 18
-
FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase
-
FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells
-
(2024)
ROS production by mitochondria: function or dysfunction?, 43
-
Pyroptosis in inflammatory diseases and cancer
-
Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway
-
FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway
-
(2017)
FAM3A protects against glutamate-induced toxicity by preserving calcium homeostasis in differentiated PC12 cells, 44
-
Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation
-
(2017)
VEGF stimulated the angiogenesis by promoting the mitochondrial functions, 8
-
(2024)
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts, 76
-
ROS production by mitochondria: function or dysfunction?
-
(2019)
Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening, 39
-
(2014)
FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury, 74
-
(2023)
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination, 14
-
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy
-
(2022)
Pyroptosis in inflammatory diseases and cancer, 12
-
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress
-
The modes of angiogenesis: an updated perspective
-
(2019)
Endothelial FAM3A positively regulates post-ischaemic angiogenesis, 43
-
(2023)
The global perspective on peroxisome proliferator-activated receptor γ (PPARγ) in ectopic fat deposition: a review, 253
-
Mechanisms of Cadmium Neurotoxicity
-
FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress
-
(2022)
PPARγ mediates protective effect against hepatic ischemia/reperfusion injury via NF-κB pathway, 35
-
Atp11p and Atp12p are chaperones for F1-ATPase biogenesis in mitochondria
-
(2023)
FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway, 59
-
Long-term clinical outcomes of Remote Ischemic Preconditioning and Postconditioning Outcome (RISPO) trial in patients undergoing cardiac surgery
-
(2023)
An overview of ATP synthase, inhibitors, and their toxicity, 9
-
Vascular endothelial growth factor biology for regenerative angiogenesis
-
(2025)
Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1, 21
-
(2023)
The modes of angiogenesis: an updated perspective, 26
-
Targeted upregulation of uncoupling protein 2 within the basal ganglia output structure ameliorates dyskinesia after severe liver failure
-
(2017)
Long-term clinical outcomes of remote ischemic preconditioning and postconditioning outcome (RISPO) trial in patients undergoing cardiac surgery, 231
-
FAM3A attenuates ER stress-induced mitochondrial dysfunction and apoptosis via CHOP-Wnt pathway
-
Glial Cells Response in Stroke
- Publisher
- Taylor & Francis
- Copyright
- © 2025 Informa UK Limited, trading as Taylor & Francis Group
- ISSN
- 1538-4101
- eISSN
- 1551-4005
- DOI
- 10.1080/15384101.2025.2527777
- Publisher site
- See Article on Publisher Site
Abstract
FAM3 metabolism-regulating signaling molecule A (FAM3A) is a mitochondrial protein belonging to the FAM3 gene family with the potential for the treatment of ischemic diseases. FAM3A promotes adenosine triphosphate (ATP) production and improves mitochondrial function by increasing ATP synthase activity and activating the protein kinase B-cyclic AMP-responsive element binding protein-forkhead box D3-ATP synthase regulatory loop, thereby reducing reactive oxygen species production and inhibiting oxidative stress-induced cell death. Additionally, FAM3A activates the nuclear factor erythroid 2-related factor 2 signaling pathway and upregulates the expression of antioxidant proteins, further enhancing the cellular oxidative defense capacity. During angiogenesis, FAM3A positively regulates vascular endothelial growth factor A and promotes endothelial cell migration, proliferation, and tube formation. FAM3A is closely related to atherosclerosis, ischemic encephalopathy, liver ischemia – reperfusion injury, myocardial ischemia, and acute kidney injury. FAM3A plays a role in the course of these diseases via multiple mechanisms, including the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, effectively reducing the inflammatory response and oxidative stress, and influencing disease development. This review comprehensively examines the role of FAM3A in the pathophysiological processes of ischemic diseases across various organs.
Journal
Cell Cycle – Taylor & Francis
Published: Apr 18, 2025
Keywords: Ischemic diseases; FAM3A; mitochondrial dysfunction