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The Evolving Story of Renal Translocation Carcinomas

The Evolving Story of Renal Translocation Carcinomas AJCP / EDITORIAL 1 2 Pedram Argani, MD, and Marc Ladanyi, MD DOI: 10.1309/EAEJTJGD5J4J3B4F The majority of renal cell carcinomas (RCCs) in adults are psammomatous calcifications. Tumors with different specific readily classified into one of several well-defined categories gene fusions may have slightly different clinical manifesta- under the 2004 World Health Organization classification, a clas- tions and morphologic features. For example, the RCCs asso- sification based on morphologic features and genetics. The types ciated with the ASPL-TFE3 gene fusion (so-called ASPL- of RCC include clear cell (conventional), papillary, chromo- TFE3 RCC) frequently present at an advanced stage and have phobe, collecting duct, and the recently described mucinous tubu- voluminous cytoplasm with extensive psammomatous calcifi- lar and spindle cell carcinoma. Many of these morphologically cations. In contrast with clear cell and papillary RCCs usual- defined entities are associated with specific genetic alterations (ie, ly seen in adults, the Xp11 translocation RCCs underexpress chromosome 3p deletion in clear cell RCC and trisomy of chro- vimentin and cytokeratins on immunohistochemical analysis, mosome 7 and 17 in papillary RCC), further validating the clas- the latter fact providing at least part of the explanation for Dr sification. Only approximately 5% of adult RCCs remain http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Clinical Pathology Oxford University Press

The Evolving Story of Renal Translocation Carcinomas

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References (19)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0002-9173
eISSN
1943-7722
DOI
10.1309/EAEJTJGD5J4J3B4F
pmid
16880145
Publisher site
See Article on Publisher Site

Abstract

AJCP / EDITORIAL 1 2 Pedram Argani, MD, and Marc Ladanyi, MD DOI: 10.1309/EAEJTJGD5J4J3B4F The majority of renal cell carcinomas (RCCs) in adults are psammomatous calcifications. Tumors with different specific readily classified into one of several well-defined categories gene fusions may have slightly different clinical manifesta- under the 2004 World Health Organization classification, a clas- tions and morphologic features. For example, the RCCs asso- sification based on morphologic features and genetics. The types ciated with the ASPL-TFE3 gene fusion (so-called ASPL- of RCC include clear cell (conventional), papillary, chromo- TFE3 RCC) frequently present at an advanced stage and have phobe, collecting duct, and the recently described mucinous tubu- voluminous cytoplasm with extensive psammomatous calcifi- lar and spindle cell carcinoma. Many of these morphologically cations. In contrast with clear cell and papillary RCCs usual- defined entities are associated with specific genetic alterations (ie, ly seen in adults, the Xp11 translocation RCCs underexpress chromosome 3p deletion in clear cell RCC and trisomy of chro- vimentin and cytokeratins on immunohistochemical analysis, mosome 7 and 17 in papillary RCC), further validating the clas- the latter fact providing at least part of the explanation for Dr sification. Only approximately 5% of adult RCCs remain

Journal

American Journal of Clinical Pathology – Oxford University Press

Published: Sep 14, 2006

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