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A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13

A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13 Wilms tumor is believed to occur as the result of two mutations affecting both alleles of a critical gene located within the p13 band of chromosome 11 (Knudson and Strong 1972; Riccardi et al. 1978). Several mechanisms by which these mutations occur have already been determined in retinoblastoma (Cavenee et al. 1983) and Wilms tumor (Koufos et al. 1984; Orkin et al. 1984; Reeve et al. 1984; Fearon et al. 1984a; Eccles et al. 1984). Of the various mechanisms, however, no example of a mitotic recombination was demonstrated in Wilms tumor. An example is presented here which has been detected by the use of restriction fragment length polymorphisms (RFLPs) mapping to chromosome 11p. In addition the data presented are consistent with the mapping location of parathyroid hormone (PTH) being proximal to 11p13. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Genetics Springer Journals

A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13

Raizis, A.; Becroft, D.; Shaw, R.; Reeve, A.
Human Genetics , Volume 70 (4) – Aug 18, 2004
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References (36)

Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Biomedicine; Human Genetics; Molecular Medicine; Gene Function; Metabolic Diseases
ISSN
0340-6717
eISSN
1432-1203
DOI
10.1007/BF00295375
Publisher site
See Article on Publisher Site

Abstract

Wilms tumor is believed to occur as the result of two mutations affecting both alleles of a critical gene located within the p13 band of chromosome 11 (Knudson and Strong 1972; Riccardi et al. 1978). Several mechanisms by which these mutations occur have already been determined in retinoblastoma (Cavenee et al. 1983) and Wilms tumor (Koufos et al. 1984; Orkin et al. 1984; Reeve et al. 1984; Fearon et al. 1984a; Eccles et al. 1984). Of the various mechanisms, however, no example of a mitotic recombination was demonstrated in Wilms tumor. An example is presented here which has been detected by the use of restriction fragment length polymorphisms (RFLPs) mapping to chromosome 11p. In addition the data presented are consistent with the mapping location of parathyroid hormone (PTH) being proximal to 11p13.

Journal

Human Genetics – Springer Journals

Published: Aug 18, 2004

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