Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Martínez, N. Cobos-Trigueros, Á. Soriano, M. Almela, M. Ortega, F. Marco, C. Pitart, H. Sterzik, J. López, J. Mensa (2010)
Influence of Empiric Therapy with a β-Lactam Alone or Combined with an Aminoglycoside on Prognosis of Bacteremia Due to Gram-Negative MicroorganismsAntimicrobial Agents and Chemotherapy, 54
J. Chow, M. Fine, D. Shlaes, J. Quinn, D. Hooper, Michaekl Johnson, R. Ramphal, M. Wagener, D. Miyashiro, V. Yu (1991)
Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy.Annals of internal medicine, 115 8
American College of Chest Physicians/Society of Critical Care Medicine (1992)
Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for use of innovative therapies in sepsisCrit Care Med, 20
L. Leibovici, Michal Paul, O. Poznanski, Moshe Drucker, Z. Samra, H. Konigsberger, S. Pitlik (1997)
Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational studyAntimicrobial Agents and Chemotherapy, 41
A. Magiorakos, A. Srinivasan, R. Carey, Y. Carmeli, M. Falagas, M. Falagas, C. Giske, S. Harbarth, J. Hindler, G. Kahlmeter, B. Olsson-liljequist, D. Paterson, L. Rice, J. Stelling, M. Struelens, A. Vatopoulos, J. Weber, D. Monnet (2012)
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 18 3
M. Hilf, V. Yu, Jane. Sharp, J. Zuravleff, J. Korvick, R. Muder (1989)
Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients.The American journal of medicine, 87 5
F. Brunkhorst, M. Oppert, G. Marx, F. Bloos, K. Ludewig, C. Putensen, A. Nierhaus, U. Jaschinski, A. Meier‑Hellmann, A. Weyland, M. Gründling, O. Moerer, R. Riessen, A. Seibel, M. Ragaller, M. Büchler, S. John, F. Bach, C. Spies, L. Reill, H. Fritz, M. Kiehntopf, E. Kuhnt, H. Bogatsch, C. Engel, M. Loeffler, M. Kollef, K. Reinhart, T. Welte (2012)
Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.JAMA, 307 22
S. Micek, Ann Lloyd, D. Ritchie, R. Reichley, V. Fraser, M. Kollef (2005)
Pseudomonas aeruginosa Bloodstream Infection: Importance of Appropriate Initial Antimicrobial TreatmentAntimicrobial Agents and Chemotherapy, 49
C. Kang, Sung‐Han Kim, W. Park, Ki-Deok Lee, Hong-Bin Kim, E. Kim, M. Oh, K. Choe (2004)
Bloodstream Infections Caused by Antibiotic-Resistant Gram-Negative Bacilli: Risk Factors for Mortality and Impact of Inappropriate Initial Antimicrobial Therapy on OutcomeAntimicrobial Agents and Chemotherapy, 49
N. Safdar, J. Handelsman, D. Maki (2004)
Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis.The Lancet. Infectious diseases, 4 8
M. Kollef, S. Ward (1998)
The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia.Chest, 113 2
D. Heyland, D. Cook, L. Griffith, S. Keenan, C. Brun-Buisson (1999)
The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group.American journal of respiratory and critical care medicine, 159 4 Pt 1
G. Bodey, L. Jadeja, L. Elting (1985)
Pseudomonas bacteremia. Retrospective analysis of 410 episodes.Archives of internal medicine, 145 9
P. Wayne (2011)
CLINICAL AND LABORATORY STANDARDS INSTITUTE. PERFORMANCE STANDARDS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING, 31
F. Vidal, J. Mensa, M. Almela, J. Martínez, F. Marco, C. Casals, J. Gatell, E. Soriano, M. Anta (1996)
Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes.Archives of internal medicine, 156 18
Anand Kumar, R. Zarychanski, B. Light, J. Parrillo, D. Maki, D. Simon, D. Laporta, S. Lapinsky, P. Ellis, Y. Mirzanejad, Greg Martinka, Sean Keenan, G. Wood, Y. Arabi, D. Feinstein, Aseem Kumar, P. Dodek, L. Kravetsky, S. Doucette (2010)
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*Critical Care Medicine, 38
E. Chamot, Emmanuelle Amari, P. Rohner, C. Delden (2003)
Effectiveness of Combination Antimicrobial Therapy for Pseudomonas aeruginosa BacteremiaAntimicrobial Agents and Chemotherapy, 47
P. Eggimann, J. Revelly (2006)
Should antibiotic combinations be used to treat ventilator-associated pneumonia?Seminars in respiratory and critical care medicine, 27 1
Leibovici, Shraga, Drucker, Konigsberger, Samra, Pitlik, Pitlik (1998)
The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infectionJournal of Internal Medicine, 244
P. Hicks, D. Cooper (2008)
The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 10 1
J. Garnacho-Montero, M. Sa-Borges, J. Solé-Violán, F. Barcenilla, A. Escoresca-Ortega, M. Ochoa, A. Cayuela, J. Rello (2007)
Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: An observational, multicenter study comparing monotherapy with combination antibiotic therapy*Critical Care Medicine, 35
Jordi Rello, M. Gallego, D. Mariscal, Rosario Sonora, J. Vallés (1997)
The value of routine microbial investigation in ventilator-associated pneumonia.American journal of respiratory and critical care medicine, 156 1
A. Kuikka, Ville Valtonen (1998)
Factors Associated with Improved Outcome of Pseudomonas aeruginosa Bacteremia in a Finnish University HospitalEuropean Journal of Clinical Microbiology and Infectious Diseases, 17
Bodey (1985)
Pseudomonas bacteremia: retrospective analysis of 410 episodesArch Intern Med, 145
Phillip Dellinger, MitchellM, Levy, JeanM, Carlet, Julian Bion, MargaretM, Parker, R. Jaeschke, K. Reinhart, DerekC, Angus, C. Brun-Buisson, Richard Beale, Thierry Calandra, J. Dhainaut, H. Gerlach, Maurene Harvey, John Marini, John Marshall, Marco Ranieri, Graham Ramsay, J. Sevransky, B. Thompson, Sean Townsend, J. Vender, JaniceL, Zimmerman, J. Vincent (2007)
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008Intensive Care Medicine, 34
Y. Siegman-Igra, Ramit Ravona, Hedva Primerman, Michael Giladi (1998)
Pseudomonas aeruginosa bacteremia: an analysis of 123 episodes, with particular emphasis on the effect of antibiotic therapy.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2 4
M. Paul, K. Soares-Weiser, L. Leibovici (2003)
β lactam monotherapy versus β lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysisBMJ : British Medical Journal, 326
M. Charlson, P. Pompei, Kathy Ales, C. MacKenzie (1987)
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.Journal of chronic diseases, 40 5
L. Magnotti, T. Schroeppel, L. Clement, J. Swanson, Tiffany Bee, G. Maish, G. Minard, B. Zarzaur, P. Fischer, T. Fabian, M. Croce (2009)
Efficacy of monotherapy in the treatment of Pseudomonas ventilator-associated pneumonia in patients with trauma.The Journal of trauma, 66 4
M. Al-Hasan, John Wilson, B. Lahr, K. Thomsen, J. Eckel-Passow, E. Vetter, I. Tleyjeh, L. Baddour (2009)
β-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative BacilliAntimicrobial Agents and Chemotherapy, 53
Anand Kumar, N. Safdar, S. Kethireddy, D. Chateau (2010)
A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/meta-regression studyCritical Care Medicine, 38
M. Paul, Ishay Benuri-Silbiger, K. Soares-Weiser, L. Leibovici (2004)
β lactam monotherapy versus β lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trialsBMJ : British Medical Journal, 328
Clinical and Laboratory Standards Institute (2012)
Performance standards for antimicrobial susceptibility testing: 20th informational supplement M100-S22
(2008)
Breakpoint tables for interpretation of MICs and zone diameters
(1992)
Society of Critical Care Medicine Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for use of innovative therapies in sepsis
J. Gall, P. Loirat, A. Alpérovitch, P. Glaser, C. Granthil, D. Mathieu, P. Mercier, Rémi Thomas, D. Villers (1984)
A simplified acute physiology score for ICU patientsCritical Care Medicine, 12
M. Ferraro (2001)
Performance standards for antimicrobial susceptibility testing
Accessed 29
C. Peña, C. Suárez, M. Gozalo, J. Murillas, B. Almirante, V. Pomar, M. Aguilar, A. Granados, E. Calbo, J. Rodríguez-Baño, F. Rodríguez, F. Tubau, L. Martínez-Martínez, A. Oliver (2011)
Prospective Multicenter Study of the Impact of Carbapenem Resistance on Mortality in Pseudomonas aeruginosa Bloodstream InfectionsAntimicrobial Agents and Chemotherapy, 56
M. Paul, L. Leibovici (2005)
Combination antibiotic therapy for Pseudomonas aeruginosa bacteraemia.The Lancet. Infectious diseases, 5 4
Empirical combination therapy is recommended for patients with known or suspected Pseudomonas aeruginosa (PA). A post hoc analysis of patients with PA bloodstream infections suggests that treatment with combination antimicrobial therapy did not reduce the mortality risk compared with single-drug therapy.
Clinical Infectious Diseases – Oxford University Press
Published: Jul 15, 2013
Keywords: bloodstream infections P. aeruginosa combination antimicrobial therapy mortality
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.