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Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1... Downloaded from genesdev.cshlp.org on November 2, 2021 - Published by Cold Spring Harbor Laboratory Press Conjugation, meiosis, and the osmotic stress response are regulated by Spcl kinase through Atfl transcription factor in fission yeast Kazuhiro Shiozaki and Paul RusselP Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037 USA The stress-activated Wisl-Spcl protein kinase cascade links mitotic control with environmental signals in Schizosaccharomyces pombe. Fission yeast spcl- mutants are delayed in G 2 during normal growth and undergo G 2 arrest when exposed to osmotic or oxidative stress. Here we report that Spcl also has an important role in regulating sexual development in S. pombe. This discovery arose from the observation that Spcl is activated in response to nitrogen limitation, a key signal that promotes conjugation in fission yeast. Mutant spcl- cells are defective at arresting in G~ during nitrogen starvation and exhibit a poor mating ability. These deficiencies correlate with a failure to induce transcription of stell ÷, a gene that encodes a transcription factor responsible for expression of various meiotic genes. Two genes, atfl + and atf21 +, were cloned as multicopy suppressors of the spcl- mating defect. Atfl and Atf21 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Shiozaki, K; Russell, P
Genes & Development – Sep 15, 1996
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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.10.18.2276
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Abstract

Downloaded from genesdev.cshlp.org on November 2, 2021 - Published by Cold Spring Harbor Laboratory Press Conjugation, meiosis, and the osmotic stress response are regulated by Spcl kinase through Atfl transcription factor in fission yeast Kazuhiro Shiozaki and Paul RusselP Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037 USA The stress-activated Wisl-Spcl protein kinase cascade links mitotic control with environmental signals in Schizosaccharomyces pombe. Fission yeast spcl- mutants are delayed in G 2 during normal growth and undergo G 2 arrest when exposed to osmotic or oxidative stress. Here we report that Spcl also has an important role in regulating sexual development in S. pombe. This discovery arose from the observation that Spcl is activated in response to nitrogen limitation, a key signal that promotes conjugation in fission yeast. Mutant spcl- cells are defective at arresting in G~ during nitrogen starvation and exhibit a poor mating ability. These deficiencies correlate with a failure to induce transcription of stell ÷, a gene that encodes a transcription factor responsible for expression of various meiotic genes. Two genes, atfl + and atf21 +, were cloned as multicopy suppressors of the spcl- mating defect. Atfl and Atf21

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Genes & Development – Unpaywall

Published: Sep 15, 1996

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