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Downloaded from Downloaded from Downloaded from genesdev.cshlp.org genesdev.cshlp.org genesdev.cshlp.org on November 25, 2021 - Published by on November 25, 2021 - Published by on November 25, 2021 - Published by Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development 1 2,3 4 1 6 Patricia Ducy, Michael Starbuck, Matthias Priemel, Jianhe Shen, Gerald Pinero, 3 5 1,7 Valerie Geoffroy, Michael Amling, and Gerard Karsenty 1 2 Department of Molecular and Human Genetics and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030 USA; Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, 4 5 Houston, Texas 77030 USA; Department of Bone Pathology and Department of Trauma Surgery, University of Hamburg, Hamburg 20246, Germany; Department of Basic Science, The University of Texas Dental Branch, Houston, Texas 77030 USA The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in
Genes & Development – Unpaywall
Published: Apr 15, 1999
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