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C-Reactive Protein and Ischemia in Users and Nonusers of &bgr;-Blockers and Statins Data From the Heart and Soul Study

C-Reactive Protein and Ischemia in Users and Nonusers of &bgr;-Blockers and Statins Data From the... C-Reactive Protein and Ischemia in Users and Nonusers of -Blockers and Statins Data From the Heart and Soul Study Mary S. Beattie, MD; Michael G. Shlipak, MD, MPH; Haiying Liu, MD, MPH; Warren S. Browner, MD, MPH; Nelson B. Schiller, MD; Mary A. Whooley, MD Background—Elevated levels of C-reactive protein (CRP) are associated with an increased risk of coronary events, but whether inflammation is associated with inducible ischemia in patients with stable coronary disease is unknown. Methods and Results—We recruited patients with known coronary disease from 2 VA Medical Centers and 1 University-based medical center for the Heart and Soul Study. We measured CRP levels in 118 participants who had exercise-induced ischemia and in 111 who did not have inducible ischemia, as determined by stress echocardiography. We used logistic regression to examine the risk of exercise-induced ischemia associated with elevated CRP. We found that 75% (39/52) of participants in the highest CRP category (0.38 mg/dL) had inducible ischemia, compared with 45% (79/177) in the lower 4 categories combined (adjusted odds ratio 4.2; 95% confidence interval 1.6 to 11; P0.004). However, this association differed in users and nonusers of -blockers and statins. Among 89 participants who did not use -blockers, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

C-Reactive Protein and Ischemia in Users and Nonusers of &bgr;-Blockers and Statins Data From the Heart and Soul Study

Whooley, Mary A.
Circulation , Volume 107 (2) – Jan 1, 2003
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References (31)

ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/01.CIR.0000044387.23578.E9
Publisher site
See Article on Publisher Site

Abstract

C-Reactive Protein and Ischemia in Users and Nonusers of -Blockers and Statins Data From the Heart and Soul Study Mary S. Beattie, MD; Michael G. Shlipak, MD, MPH; Haiying Liu, MD, MPH; Warren S. Browner, MD, MPH; Nelson B. Schiller, MD; Mary A. Whooley, MD Background—Elevated levels of C-reactive protein (CRP) are associated with an increased risk of coronary events, but whether inflammation is associated with inducible ischemia in patients with stable coronary disease is unknown. Methods and Results—We recruited patients with known coronary disease from 2 VA Medical Centers and 1 University-based medical center for the Heart and Soul Study. We measured CRP levels in 118 participants who had exercise-induced ischemia and in 111 who did not have inducible ischemia, as determined by stress echocardiography. We used logistic regression to examine the risk of exercise-induced ischemia associated with elevated CRP. We found that 75% (39/52) of participants in the highest CRP category (0.38 mg/dL) had inducible ischemia, compared with 45% (79/177) in the lower 4 categories combined (adjusted odds ratio 4.2; 95% confidence interval 1.6 to 11; P0.004). However, this association differed in users and nonusers of -blockers and statins. Among 89 participants who did not use -blockers,

Journal

Circulation – Wolters Kluwer Health

Published: Jan 1, 2003

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