Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

How does adrenaline accelerate the heart?

How does adrenaline accelerate the heart? THE way in which adrenaline acts on the sinoatrial (SA) node to accelerate the heart rate has hitherto been obscure. However, in various other parts of the heart adrenaline increases the slow inward (Ca2+/Na+) current1–4, and voltage-recording experiments have indicated that adrenaline also has this action in the sinus region5–7. In the voltage-clamp experiments reported here, we find that adrenaline does indeed increase the slow inward current in the SA node of the rabbit, but that it also augments the outward current which would tend to decelerate pacemaker depolarisation. We find that an additional current, i f, is activated within the range of voltage where the pacemaker depolarisation occurs: this could be important both in normal pacemaking and in adrenaline-induced acceleration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

How does adrenaline accelerate the heart?

BROWN, H. F.; DIFRANCESCO, D.; NOBLE, S. J.
Nature , Volume 280 (5719) – Jul 1, 1980
Download PDF
2 pages

Loading next page...
 
/lp/springer-journals/how-does-adrenaline-accelerate-the-heart-gJ4FykkYJ3

References (5)

Publisher
Springer Journals
Copyright
Copyright © 1979 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/280235a0
Publisher site
See Article on Publisher Site

Abstract

THE way in which adrenaline acts on the sinoatrial (SA) node to accelerate the heart rate has hitherto been obscure. However, in various other parts of the heart adrenaline increases the slow inward (Ca2+/Na+) current1–4, and voltage-recording experiments have indicated that adrenaline also has this action in the sinus region5–7. In the voltage-clamp experiments reported here, we find that adrenaline does indeed increase the slow inward current in the SA node of the rabbit, but that it also augments the outward current which would tend to decelerate pacemaker depolarisation. We find that an additional current, i f, is activated within the range of voltage where the pacemaker depolarisation occurs: this could be important both in normal pacemaking and in adrenaline-induced acceleration.

Journal

Nature – Springer Journals

Published: Jul 1, 1980

There are no references for this article.