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Humoral and Cellular Immunity in Humans Studied at the Cell Level from Birth to Two Years of Age

Humoral and Cellular Immunity in Humans Studied at the Cell Level from Birth to Two Years of Age Humoral and Cellular Immunity in Humans Studied at the Cell Level from Birth to Two Years of Age U. ANDERSSON, A. G. BrRD, S. BRITTON & R. PALACIOS INTRODUCTION Infections remain a leading cause of neonatal death in spite of improvements in public health and medical care including the use of antibiotics. The incidence of life threatening viral and bacterial infections in human newborns is much higher than in adults. Intense studies of the reasons for this have led to various and sometimes conflicting conclusions. Lack of earlier antigenic experience, intrinsic immaturity of lymphocyte functions and active cellular suppressive mechanisms, or a combination of these possibilities, are suggested explanations (Lawton et al. 1972, Stiehm 1975, Xanthou et al. 1976, Hayward & Lawton 1977, Oldstone et al. 1977, Miller 1978). Many conclusions about human B lymphocyte function in the neonate have been derived from the immunochemical analysis of immunoglobulins present in the serum of the neonate and developing infant. Such studies have been fraught with difficulty both because of the presence of passively transferred maternal IgG and its secondary interference with any attempts to induce in vivo antigenic challenge. In viiro specific antigenic responses have, with a few notable http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunological Reviews Wiley

Humoral and Cellular Immunity in Humans Studied at the Cell Level from Birth to Two Years of Age

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References (78)

Publisher
Wiley
Copyright
Copyright © 1981 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-2896
eISSN
1600-065X
DOI
10.1111/j.1600-065X.1981.tb00440.x
Publisher site
See Article on Publisher Site

Abstract

Humoral and Cellular Immunity in Humans Studied at the Cell Level from Birth to Two Years of Age U. ANDERSSON, A. G. BrRD, S. BRITTON & R. PALACIOS INTRODUCTION Infections remain a leading cause of neonatal death in spite of improvements in public health and medical care including the use of antibiotics. The incidence of life threatening viral and bacterial infections in human newborns is much higher than in adults. Intense studies of the reasons for this have led to various and sometimes conflicting conclusions. Lack of earlier antigenic experience, intrinsic immaturity of lymphocyte functions and active cellular suppressive mechanisms, or a combination of these possibilities, are suggested explanations (Lawton et al. 1972, Stiehm 1975, Xanthou et al. 1976, Hayward & Lawton 1977, Oldstone et al. 1977, Miller 1978). Many conclusions about human B lymphocyte function in the neonate have been derived from the immunochemical analysis of immunoglobulins present in the serum of the neonate and developing infant. Such studies have been fraught with difficulty both because of the presence of passively transferred maternal IgG and its secondary interference with any attempts to induce in vivo antigenic challenge. In viiro specific antigenic responses have, with a few notable

Journal

Immunological Reviews – Wiley

Published: Aug 1, 1981

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