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Movements of labelled calcium in squid giant axons

Movements of labelled calcium in squid giant axons Physiol. ('957) I38, 253-28I J. OF LABELLED CALCIUM MOVEMENTS IN SQUID GIANT AXONS AND R. D. By A. L. HODGKIN KEYNES From the Physiological Laboratory, University of Cambridge and the Laboratory of the Marine Biological Association, Plymouth (Received 24 May 1957) amount is known about the in which calcium affect the A certain way may of nerve membranes to sodium and ions permeability potassium (see Brink, Frankenhaeuser & but there is little information about 1954; Hodgkin, 1957), the to calcium itself. The main of the permeability object experiments in this was to measure the which described paper rate at calcium labelled with the radioactive 45Ca crosses the surface membrane of isotope resting squid and to whether calcium moves axons, see faster through the membrane during nervous activity. on the of cell to Investigations permeability membranes labelled substances are often complicated by uncertainty as to whether a of the intracellular genuine penetration region has taken place, or only an exchange with extracellular material. Such doubts tend to be acute especially with a substance like calcium whose internal concentration is very low (Keynes & Lewis, 1956). The squid giant axon is a for good preparation studying calcium permeability, because extruded axoplasm http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Movements of labelled calcium in squid giant axons

Hodgkin, A. L.; Keynes, R. D.
The Journal of Physiology , Volume 138 (2) – Jan 23, 1957
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References (28)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1957.sp005850
Publisher site
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Abstract

Physiol. ('957) I38, 253-28I J. OF LABELLED CALCIUM MOVEMENTS IN SQUID GIANT AXONS AND R. D. By A. L. HODGKIN KEYNES From the Physiological Laboratory, University of Cambridge and the Laboratory of the Marine Biological Association, Plymouth (Received 24 May 1957) amount is known about the in which calcium affect the A certain way may of nerve membranes to sodium and ions permeability potassium (see Brink, Frankenhaeuser & but there is little information about 1954; Hodgkin, 1957), the to calcium itself. The main of the permeability object experiments in this was to measure the which described paper rate at calcium labelled with the radioactive 45Ca crosses the surface membrane of isotope resting squid and to whether calcium moves axons, see faster through the membrane during nervous activity. on the of cell to Investigations permeability membranes labelled substances are often complicated by uncertainty as to whether a of the intracellular genuine penetration region has taken place, or only an exchange with extracellular material. Such doubts tend to be acute especially with a substance like calcium whose internal concentration is very low (Keynes & Lewis, 1956). The squid giant axon is a for good preparation studying calcium permeability, because extruded axoplasm

Journal

The Journal of Physiology – Wiley

Published: Jan 23, 1957

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