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Porous polylactide/β‐tricalcium phosphate composite scaffolds for tissue engineering applications

Porous polylactide/β‐tricalcium phosphate composite scaffolds for tissue engineering applications Porous polylactide/β‐tricalcium phosphate (PLA/β‐TCP) composite scaffolds were fabricated by freeze‐drying. The aim of this study was to characterize these graded porous composite scaffolds in two different PLA concentrations (2 and 3 wt%). Also, three different β‐TCP ratios (5, 10 and 20 wt%) were used to study the effect of β‐TCP on the properties of the polymer. The characterization was carried out by determining the pH, weight change, component ratios, thermal stability, inherent viscosity and microstructure of the scaffolds in 26 weeks of hydrolysis. This study indicated that no considerable change was noticed in the structure of the scaffolds when the β‐TCP filler was added. Also, the amount of β‐TCP did not affect the pore size or the pore distribution in the scaffolds. We observed that the fabrication method improved the thermal stability of the samples. Our results suggest that, from the structural point of view, these scaffolds could have potential for the treatment of osteochondral defects in tissue engineering applications. The porous bottom surface of the scaffold and the increased osteogenic differentiation potential achieved with β‐TCP particles may encourage the growth of bone cells. In addition, the dense surface skin of the scaffold may inhibit the ingrowth of osteoblasts and bone tissue, while simultaneously encouraging the ingrowth of chondrocytes. Copyright © 2010 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Tissue Engineering and Regenerative Medicine Wiley

Porous polylactide/β‐tricalcium phosphate composite scaffolds for tissue engineering applications

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References (43)

Publisher
Wiley
Copyright
Copyright © 2010 John Wiley & Sons, Ltd.
ISSN
1932-6254
eISSN
1932-7005
DOI
10.1002/term.249
pmid
20084622
Publisher site
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Abstract

Porous polylactide/β‐tricalcium phosphate (PLA/β‐TCP) composite scaffolds were fabricated by freeze‐drying. The aim of this study was to characterize these graded porous composite scaffolds in two different PLA concentrations (2 and 3 wt%). Also, three different β‐TCP ratios (5, 10 and 20 wt%) were used to study the effect of β‐TCP on the properties of the polymer. The characterization was carried out by determining the pH, weight change, component ratios, thermal stability, inherent viscosity and microstructure of the scaffolds in 26 weeks of hydrolysis. This study indicated that no considerable change was noticed in the structure of the scaffolds when the β‐TCP filler was added. Also, the amount of β‐TCP did not affect the pore size or the pore distribution in the scaffolds. We observed that the fabrication method improved the thermal stability of the samples. Our results suggest that, from the structural point of view, these scaffolds could have potential for the treatment of osteochondral defects in tissue engineering applications. The porous bottom surface of the scaffold and the increased osteogenic differentiation potential achieved with β‐TCP particles may encourage the growth of bone cells. In addition, the dense surface skin of the scaffold may inhibit the ingrowth of osteoblasts and bone tissue, while simultaneously encouraging the ingrowth of chondrocytes. Copyright © 2010 John Wiley & Sons, Ltd.

Journal

Journal of Tissue Engineering and Regenerative Medicine – Wiley

Published: Jul 1, 2010

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