Access the full text.
Sign up today, get DeepDyve free for 14 days.
Krishanu Saha, Albert Keung, E. Irwin, Yang Li, Lauren Little, D. Schaffer, K. Healy (2008)
Substrate modulus directs neural stem cell behavior.Biophysical journal, 95 9
B. Giepmans, S. Adams, Mark Ellisman, R. Tsien (2006)
The Fluorescent Toolbox for Assessing Protein Location and FunctionScience, 312
G. Devault, J. McLennan (1965)
Statistical Mechanics of ViscoelasticityPhysical Review, 137
B. Chae, E. Furst (2005)
Probe surface chemistry dependence and local polymer network structure in F-actin microrheology.Langmuir : the ACS journal of surfaces and colloids, 21 7
M. Lutolf, Janelle Lauer-Fields, H. Schmoekel, A. Metters, F. Weber, G. Fields, J. Hubbell (2003)
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristicsProceedings of the National Academy of Sciences of the United States of America, 100
R. Pelham, Yu-li Wang (1997)
Cell locomotion and focal adhesions are regulated by substrate flexibility.Proceedings of the National Academy of Sciences of the United States of America, 94 25
Cole DeForest, B. Polizzotti, K. Anseth (2009)
Sequential Click Reactions for Synthesizing and Patterning 3D Cell MicroenvironmentsNature materials, 8
H. Winter, F. Chambon (1986)
Analysis of Linear Viscoelasticity of a Crosslinking Polymer at the Gel PointJournal of Rheology, 30
M. Lutolf, M. Lutolf, J. Hubbell (2005)
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineeringNature Biotechnology, 23
Jingyuan Xu, V. Viasnoff, Denis Wirtz (1998)
Compliance of actin filament networks measured by particle-tracking microrheology and diffusing wave spectroscopyRheologica Acta, 37
J. Burdick, A. Khademhosseini, R. Langer (2004)
Fabrication of gradient hydrogels using a microfluidics/photopolymerization process.Langmuir : the ACS journal of surfaces and colloids, 20 13
S. Sen, Sanjay Kumar (2010)
Combining mechanical and optical approaches to dissect cellular mechanobiology.Journal of biomechanics, 43 1
A. Engler, L. Richert, J. Wong, C. Picart, D. Discher (2004)
Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films : correlations between substrate stiffness and cell adhesionSurface Science, 570
F. Chowdhury, S. Na, Dong Li, Y. Poh, Tetsuya Tanaka, Fei Wang, Ning Wang (2009)
Cell material property dictates stress-induced spreading and differentiation in embryonic stem cellsNature materials, 9
M. Valentine, Z. Perlman, M. Gardel, J. Shin, P. Matsudaira, T. Mitchison, D. Weitz (2004)
Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials.Biophysical journal, 86 6
A. Engler, A. Engler, S. Sen, S. Sen, H. Sweeney, D. Discher (2006)
Matrix Elasticity Directs Stem Cell Lineage SpecificationCell, 126
Soo‐Hong Lee, James Moon, J. West (2008)
Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.Biomaterials, 29 20
(2009)
KGaA, Weinheim 3494 www.advmat.de www.MaterialsViews.com P R O G R ES
R. Zwanzig, M. Bixon (1970)
Hydrodynamic Theory of the Velocity Correlation FunctionPhysical Review A, 2
Stacey Maskarinec, Christian Franck, D. Tirrell, G. Ravichandran (2009)
Quantifying cellular traction forces in three dimensionsProceedings of the National Academy of Sciences, 106
Jin Zhang, R. Campbell, A. Ting, R. Tsien (2002)
Creating new fluorescent probes for cell biologyNature Reviews Molecular Cell Biology, 3
S. Bryant, C. Nuttelman, K. Anseth (2000)
Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitroJournal of Biomaterials Science, Polymer Edition, 11
A. Mammoto, D. Ingber (2009)
Cytoskeletal control of growth and cell fate switching.Current opinion in cell biology, 21 6
J. Crocker, M. Valentine, E. Weeks, T. Gisler, P. Kaplan, A. Yodh, D. Weitz (2000)
Two-point microrheology of inhomogeneous soft materials.Physical review letters, 85 4
Sudhir Khetan, Joshua Katz, J. Burdick (2009)
Sequential crosslinking to control cellular spreading in 3-dimensional hydrogelsSoft Matter, 5
Christopher Williams, Tae Kim, A. Taboas, Athar Malik, P. Manson, J. Elisseeff (2003)
In vitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel.Tissue engineering, 9 4
S. Lin‐Gibson, Ronald Jones, N. Washburn, F. Horkay (2005)
Structure-Property Relationships of Photopolymerizable Poly(Ethylene Glycol) Dimethacrylate HydrogelsMacromolecules, 38
Zarana Patel, A. Mikos (2004)
Angiogenesis with biomaterial-based drug- and cell-delivery systemsJournal of Biomaterials Science, Polymer Edition, 15
H. Winter (1987)
Can the gel point of a cross-linking polymer be detected by the G′ – G″ crossover?Polymer Engineering and Science, 27
Jamie Ifkovits, J. Burdick (2007)
Review: photopolymerizable and degradable biomaterials for tissue engineering applications.Tissue engineering, 13 10
H. Kong, Chan Kim, Nathaniel Huebsch, D. Weitz, D. Mooney (2007)
Noninvasive probing of the spatial organization of polymer chains in hydrogels using fluorescence resonance energy transfer (FRET).Journal of the American Chemical Society, 129 15
F. MacKintosh, F. MacKintosh, J. Käs, J. Käs, P. Janmey, P. Janmey (1995)
Elasticity of semiflexible biopolymer networks.Physical review letters, 75 24
Katarina Wolf, P. Friedl (2009)
Mapping proteolytic cancer cell-extracellular matrix interfacesClinical & Experimental Metastasis, 26
R. Derda, A. Laromaine, A. Mammoto, Sindy Tang, T. Mammoto, D. Ingber, G. Whitesides (2009)
Paper-supported 3D cell culture for tissue-based bioassaysProceedings of the National Academy of Sciences, 106
C. Nelson, M. Vanduijn, J. Inman, D. Fletcher, M. Bissell (2006)
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic CulturesScience, 314
Nathaniel Hwang, S. Varghese, Zijun Zhang, J. Elisseeff (2006)
Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.Tissue engineering, 12 9
Kelly Schultz, Aaron Baldwin, K. Kiick, E. Furst (2009)
Gelation of Covalently Cross-Linked PEG-Heparin Hydrogels.Macromolecules, 42 14
S. Bryant, K. Anseth, D. Lee, D. Bader (2004)
Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strainJournal of Orthopaedic Research, 22
Soo‐Hong Lee, James Moon, Jordan Miller, J. West (2007)
Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration.Biomaterials, 28 20
J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, Robert Brown (2002)
Myofibroblasts and mechano-regulation of connective tissue remodellingNature Reviews Molecular Cell Biology, 3
Christopher Chen (2008)
Mechanotransduction – a field pulling together?Journal of Cell Science, 121
Mu Wang, R. Hill (2008)
Electric-field-induced displacement of charged spherical colloids in compressible hydrogels.Soft matter, 4 5
M. Berkooz, Anton Kapustin (1998)
New IR dualities in supersymmetric gauge theory in three dimensionsJournal of High Energy Physics, 1999
G. Hudalla, Timothy Eng, W. Murphy (2008)
An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks.Biomacromolecules, 9 3
Schuyler VanEngelenburg, A. Palmer (2008)
Fluorescent biosensors of protein function.Current opinion in chemical biology, 12 1
April Kloxin, Mark Tibbitt, A. Kasko, Jonathan Fairbairn, K. Anseth (2010)
Tunable Hydrogels for External Manipulation of Cellular Microenvironments through Controlled PhotodegradationAdvanced Materials, 22
D. Wirtz (2009)
Particle-tracking microrheology of living cells: principles and applications.Annual review of biophysics, 38
A. Levine, T. Lubensky (2000)
One- and two-particle microrheologyPhysical review letters, 85 8
T. Gisler, D. Weitz (1999)
Scaling of the microrheology of semidilute F-actin solutionsPhysical Review Letters, 82
J. Wong, A. Velasco, P. Rajagopalan, Q. Pham (2003)
Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogels†Langmuir, 19
Thomas Mason, Thomas Mason, D. Weitz (1995)
Optical measurements of frequency-dependent linear viscoelastic moduli of complex fluids.Physical review letters, 74 7
K. Ghosh, C. Thodeti, A. Dudley, A. Mammoto, M. Klagsbrun, D. Ingber (2008)
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitroProceedings of the National Academy of Sciences, 105
H. Mori (1965)
Transport, Collective Motion, and Brownian MotionProgress of Theoretical Physics, 33
C. Oelschlaeger, M. Schopferer, F. Scheffold, N. Willenbacher (2009)
Linear-to-branched micelles transition: a rheometry and diffusing wave spectroscopy (DWS) study.Langmuir : the ACS journal of surfaces and colloids, 25 2
Kelly Schultz, Aaron Baldwin, K. Kiick, E. Furst (2009)
Rapid rheological screening to identify conditions of biomaterial hydrogelation.Soft matter, 5 4
Zhijie Sui, W. King, W. Murphy (2008)
Protein‐Based Hydrogels with Tunable Dynamic ResponsesAdvanced Functional Materials, 18
D. Ingber (2008)
Tensegrity-based mechanosensing from macro to micro.Progress in biophysics and molecular biology, 97 2-3
Paul Nowatzki, Christian Franck, Stacey Maskarinec, G. Ravichandran, D. Tirrell (2008)
Mechanically Tunable Thin Films of Photosensitive Artificial Proteins: Preparation and Characterization by NanoindentationMacromolecules, 41
R. Brau, J. Ferrer, Hyungsuk Lee, C. Castro, B. Tam, P. Tarsa, P. Matsudaira, M. Boyce, R. Kamm, M. Lang (2007)
Passive and active microrheology with optical tweezersJournal of Optics A: Pure and Applied Optics, 9
J. Domke, M. Radmacher (1998)
Measuring the Elastic Properties of Thin Polymer Films with the Atomic Force MicroscopeLangmuir, 14
M. Lutolf, G. Raeber, A. Zisch, Nicola Tirelli, J. Hubbell (2003)
Cell‐Responsive Synthetic HydrogelsAdvanced Materials, 15
Yiider Tseng, T. Kole, D. Wirtz (2002)
Micromechanical mapping of live cells by multiple-particle-tracking microrheology.Biophysical journal, 83 6
G. Silva, C. Czeisler, Krista Niece, E. Beniash, D. Harrington, J. Kessler, S. Stupp (2004)
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density NanofibersScience, 303
Katarina Wolf, Yi Wu, Yi Wu, Yueying Liu, J. Geiger, E. Tam, E. Tam, C. Overall, M. Stack, P. Friedl (2007)
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasionNature Cell Biology, 9
G. Raeber, M. Lutolf, J. Hubbell (2005)
Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration.Biophysical journal, 89 2
Erin Baker, R. Bonnecaze, M. Zaman (2009)
Extracellular matrix stiffness and architecture govern intracellular rheology in cancer.Biophysical journal, 97 4
H. Nagase, G. Fields (1996)
Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides.Biopolymers, 40 4
F. Chambon, H. Winter (1985)
Stopping of crosslinking reaction in a PDMS polymer at the gel pointPolymer Bulletin, 13
G. Raeber, M. Lutolf, J. Hubbell (2007)
Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs.Acta biomaterialia, 3 5
Shelly Peyton, C. Raub, Vic Keschrumrus, A. Putnam (2006)
The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells.Biomaterials, 27 28
Nadia Zaari, P. Rajagopalan, Sooyoung Kim, A. Engler, J. Wong (2004)
Photopolymerization in Microfluidic Gradient Generators: Microscale Control of Substrate Compliance to Manipulate Cell ResponseAdvanced Materials, 16
A. Metters, J. Hubbell (2005)
Network formation and degradation behavior of hydrogels formed by Michael-type addition reactions.Biomacromolecules, 6 1
H. James, E. Guth (1943)
Theory of the Elastic Properties of RubberJournal of Chemical Physics, 11
R. Kubo (1966)
The fluctuation-dissipation theoremReports on Progress in Physics, 29
F. Guilak, Daniel Cohen, B. Estes, J. Gimble, W. Liedtke, Christopher Chen (2009)
Control of stem cell fate by physical interactions with the extracellular matrix.Cell stem cell, 5 1
Benjamin Fairbanks, Michael Schwartz, Alexandra Halevi, C. Nuttelman, C. Bowman, K. Anseth (2009)
A Versatile Synthetic Extracellular Matrix Mimic via Thiol‐Norbornene PhotopolymerizationAdvanced Materials, 21
B. Slaughter, S. Khurshid, O. Fisher, A. Khademhosseini, N. Peppas (2009)
Hydrogels in Regenerative MedicineAdvanced Materials, 21
J. Solon, I. Levental, K. Sengupta, Penelope Georges, P. Janmey (2007)
Fibroblast adaptation and stiffness matching to soft elastic substrates.Biophysical journal, 93 12
Stacey Maskarinec, D. Tirrell (2005)
Protein engineering approaches to biomaterials design.Current opinion in biotechnology, 16 4
C. Adelöw, T. Segura, J. Hubbell, P. Frey (2008)
The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype.Biomaterials, 29 3
M. Frey, Yu-li Wang (2009)
A photo-modulatable material for probing cellular responses to substrate rigidity.Soft matter, 5
M. Frey, A. Engler, D. Discher, Juliet Lee, Yu-li Wang (2007)
Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy.Methods in cell biology, 83
Alex Aimetti, Alexandra Machen, K. Anseth (2009)
Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery.Biomaterials, 30 30
Christopher Chen, M. Mrksich, Sui Huang, G. Whitesides, D. Ingber (1997)
Geometric control of cell life and death.Science, 276 5317
R. Singhvi, Ashok Kumar, G. López, G. Stephanopoulos, Daniel Wang, G. Whitesides, D. Ingber (1994)
Engineering cell shape and function.Science, 264 5159
K. Moffat, Wan-Hsuan Sun, Paul Pena, N. Chahine, S. Doty, G. Ateshian, C. Hung, Helen Lu (2008)
Characterization of the structure–function relationship at the ligament-to-bone interfaceProceedings of the National Academy of Sciences, 105
A. Mammoto, Sui Huang, K. Moore, P. Oh, D. Ingber (2004)
Role of RhoA, mDia, and ROCK in Cell Shape-dependent Control of the Skp2-p27kip1 Pathway and the G1/S Transition*Journal of Biological Chemistry, 279
Cynthia Reinhart-King, M. Dembo, D. Hammer (2008)
Cell-cell mechanical communication through compliant substrates.Biophysical journal, 95 12
M. Mahoney, K. Anseth (2006)
Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels.Biomaterials, 27 10
P. Flory, J. Rehner (1943)
Statistical Mechanics of Cross‐Linked Polymer Networks I. Rubberlike ElasticityJournal of Chemical Physics, 11
I. Chung, N. Enemchukwu, Sirajud Khaja, N. Murthy, A. Mantalaris, Andrés García (2008)
Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis.Biomaterials, 29 17
M. Hahn, J. S. Miller, J. West (2006)
Three‐Dimensional Biochemical and Biomechanical Patterning of Hydrogels for Guiding Cell BehaviorAdvanced Materials, 18
Cyrus Ghajar, V. Suresh, Shelly Peyton, C. Raub, F. Meyskens, S. George, A. Putnam (2007)
A novel three-dimensional model to quantify metastatic melanoma invasionMolecular Cancer Therapeutics, 6
L. Treloar (1943)
The elasticity of a network of long-chain molecules.—IIITransactions of The Faraday Society, 39
Alex Aimetti, Mark Tibbitt, K. Anseth (2009)
Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) HydrogelsBiomacromolecules, 10
M. Lutolf, J. Hubbell (2003)
Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.Biomacromolecules, 4 3
F. Amblard, B. Yurke, A. Pargellis, S. Leibler (1996)
A magnetic manipulator for studying local rheology and micromechanical properties of biological systemsReview of Scientific Instruments, 67
R. Capito, H. Azevedo, Y. Velichko, A. Mata, S. Stupp (2008)
Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and MembranesScience, 319
Andre Palmer, Thomas Mason, Jingyuan Xu, S. Kuo, Denis Wirtz (1999)
Diffusing wave spectroscopy microrheology of actin filament networks.Biophysical journal, 76 2
J. Crocker, D. Grier (1996)
Methods of Digital Video Microscopy for Colloidal Studies, 179
K. Ghosh, D. Ingber (2007)
Micromechanical control of cell and tissue development: implications for tissue engineering.Advanced drug delivery reviews, 59 13
C. Chung, M. Beecham, R. Mauck, J. Burdick (2009)
The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells.Biomaterials, 30 26
S. Heilshorn, Kathleen Dizio, E. Welsh, D. Tirrell (2003)
Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins.Biomaterials, 24 23
Shaoqiong Liu, Richie Tay, Majad Khan, P. Ee, J. Hedrick, Yi Yang (2010)
Synthetic hydrogels for controlled stem cell differentiationSoft Matter, 6
M. Gardel, M. Valentine, J. Crocker, A. Bausch, D. Weitz (2003)
Microrheology of entangled F-actin solutions.Physical review letters, 91 15
L. Starrs, P. Bartlett (2002)
Colloidal dynamics in polymer solutions: optical two-point microrheology measurements.Faraday discussions, 123
B. Mann, A. Gobin, A. Tsai, R. Schmedlen, J. West (2001)
Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering.Biomaterials, 22 22
F. Wall (1942)
Statistical Thermodynamics of Rubber. IIJournal of Chemical Physics, 10
A. Cucheval, R. Vincent, Y. Hemar, D. Otter, M. Williams (2009)
Multiple particle tracking investigations of acid milk gels using tracer particles with designed surface chemistries and comparison with diffusing wave spectroscopy studies.Langmuir : the ACS journal of surfaces and colloids, 25 19
Hydrogels are increasingly employed as multidimensional cell culture platforms often with a necessity that they respond to or control the cellular environment. Specifically, synthetic hydrogels, such as poly(ethylene glycol) (PEG)‐based gels, are frequently utilized for probing the microenvironment's influence on cell function, as the gel properties can be precisely controlled in space and time. Synthetically tunable parameters, such as monomer structure and concentration, facilitate initial gel property control, while incorporation of responsive degradable units enables cell‐ and/or user‐directed degradation. Such responsive gel systems are complex with dynamic changes occurring over multiple time‐scales, and cells encapsulated in these synthetic hydrogels often experience and dictate local property changes profoundly different from those in the bulk material. Consequently, advances in bulk and local measurement techniques are needed to monitor property evolution quantatively and understand its effect on cell function. Here, recent progress in cell‐responsive PEG hydrogel synthesis and mechanical property characterization is reviewed.
Advanced Materials – Wiley
Published: Aug 17, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.