Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients

Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients Myocardial ATP-sensitive potassium (K ATP ) channels have been implicated in attenuating cardiac hypertrophy by modulating endothelin-1 concentrations. Sulfonylureas differ in their affinity for cardiac K ATP channels and therefore may vary in their effects on left ventricular (LV) mass. We sought to determine the differential effects of sulfonylureas on LV mass in type 2 diabetic patients. All patients had been taking glibenclamide for more than 3 mo before being randomized to either switch to an equipotent dose of gliclazide or continue glibenclamide. A total of consecutive 240 diabetic patients were randomized into glibenclamide, gliclazide, a combination of glibenclamide and nicorandil, or gliclazide and nicorandil for 6 mo. In the gliclazide-treated group, the LV mass index was significantly decreased compared with that in the glibenclamide-treated groups. Nicorandil administration significantly reduced LV mass in glibenclamide-treated patients compared with patients treated with glibenclamide alone. Measurements of endothelin-1 concentrations mirrored the functional status of K ATP channel. Multivariate analysis revealed that regression of LV mass was significantly correlated only with the changes in endothelin-1 ( P < 0.0001). Our results show that K ATP channels may play a pathogenetic role, probably through an endothelin-1-dependent pathway, in diabetes mellitus-related ventricular hypertrophy. Patients treated with gliclazide may have a beneficial effect in attenuating ventricular mass. adenosine 5'-triphosphate-sensitive potassium channels; diabetes mellitus; glibenclamide; gliclazide; ventricular hypertrophy Address for reprint requests and other correspondence: N.-C. Chang, Cardiology Section, Dept. of Medicine, Taipei Medical Univ. and Hospital, 252 Wu-Hsing St., Taipei 110, Taiwan (e-mail: [email protected] ) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients

Download PDF
7 pages

Loading next page...
 
/lp/the-american-physiological-society/effects-of-sulfonylureas-on-left-ventricular-mass-in-type-2-diabetic-hC70CbWyHa

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
DOI
10.1152/ajpheart.00516.2006
pmid
16936007
Publisher site
See Article on Publisher Site

Abstract

Myocardial ATP-sensitive potassium (K ATP ) channels have been implicated in attenuating cardiac hypertrophy by modulating endothelin-1 concentrations. Sulfonylureas differ in their affinity for cardiac K ATP channels and therefore may vary in their effects on left ventricular (LV) mass. We sought to determine the differential effects of sulfonylureas on LV mass in type 2 diabetic patients. All patients had been taking glibenclamide for more than 3 mo before being randomized to either switch to an equipotent dose of gliclazide or continue glibenclamide. A total of consecutive 240 diabetic patients were randomized into glibenclamide, gliclazide, a combination of glibenclamide and nicorandil, or gliclazide and nicorandil for 6 mo. In the gliclazide-treated group, the LV mass index was significantly decreased compared with that in the glibenclamide-treated groups. Nicorandil administration significantly reduced LV mass in glibenclamide-treated patients compared with patients treated with glibenclamide alone. Measurements of endothelin-1 concentrations mirrored the functional status of K ATP channel. Multivariate analysis revealed that regression of LV mass was significantly correlated only with the changes in endothelin-1 ( P < 0.0001). Our results show that K ATP channels may play a pathogenetic role, probably through an endothelin-1-dependent pathway, in diabetes mellitus-related ventricular hypertrophy. Patients treated with gliclazide may have a beneficial effect in attenuating ventricular mass. adenosine 5'-triphosphate-sensitive potassium channels; diabetes mellitus; glibenclamide; gliclazide; ventricular hypertrophy Address for reprint requests and other correspondence: N.-C. Chang, Cardiology Section, Dept. of Medicine, Taipei Medical Univ. and Hospital, 252 Wu-Hsing St., Taipei 110, Taiwan (e-mail: [email protected] )

Journal

AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Jan 1, 2007

There are no references for this article.