J. Mumm, J. Emmerich, Xueqing Zhang, I. Chan, Lingling Wu, S. Mauze, S. Blaisdell, B. Basham, J. Dai, Jeff Grein, C. Sheppard, Kyu Hong, C. Cutler, S. Turner, D. Laface, M. Kleinschek, Michael Judo, G. Ayanoglu, J. Langowski, Danling Gu, Brittany Paporello, E. Murphy, V. Sriram, Saraswathi Naravula, B. Desai, S. Medicherla, W. Seghezzi, T. Mcclanahan, S. Cannon-Carlson, A. Beebe, M. Oft (2011)
IL-10 elicits IFNγ-dependent tumor immune surveillance.Cancer cell, 20 6
Li Yang, Yanli Pang, H. Moses (2010)
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.Trends in immunology, 31 6
A. Sica, P. Larghi, A. Mancino, Luca Rubino, C. Porta, M. Totaro, M. Rimoldi, S. Biswas, P. Allavena, A. Mantovani (2008)
Macrophage polarization in tumour progression.Seminars in cancer biology, 18 5
P. Sinha, K. H. Parker, L. Horn, S. Ostrand‐Rosenberg (2012)
Tumor‐induced myeloid‐derived suppressor cell function is independent of IFN‐gamma and IL‐4Ralpha, 42
Sheinei Saleem, Rebecca Martin, Johanna Morales, J. Sturgill, D. Gibb, L. Graham, H. Bear, M. Manjili, J. Ryan, D. Conrad (2012)
Cutting Edge: Mast Cells Critically Augment Myeloid-Derived Suppressor Cell ActivityThe Journal of Immunology, 189
F. Santer, K. Malinowska, Z. Culig, I. Cavarretta (2010)
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cellsEndocrine-Related Cancer, 17
Pooran Qasimi, A. Ming-Lum, A. Ghanipour, C. Ong, M. Cox, J. Ihle, Nicolas Cacalano, A. Yoshimura, A. Mui (2006)
Divergent Mechanisms Utilized by SOCS3 to Mediate Interleukin-10 Inhibition of Tumor Necrosis Factor α and Nitric Oxide Production by Macrophages*Journal of Biological Chemistry, 281
B. Neven, E. Mamessier, J. Bruneau, S. Kaltenbach, D. Kotlarz, F. Suarez, J. Masliah-Planchon, K. Billot, D. Canioni, P. Frange, I. Radford‐Weiss, V. Asnafi, D. Murugan, C. Bole, P. Nitschké, O. Goulet, J. Casanova, S. Blanche, C. Picard, O. Hermine, F. Rieux-Laucat, N. Brousse, F. Davi, V. Baud, C. Klein, B. Nadel, F. Ruemmele, A. Fischer (2012)
A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.Blood, 122 23
A. Viola, A. Sarukhan, V. Bronte, B. Molon (2012)
The pros and cons of chemokines in tumor immunology.Trends in immunology, 33 10
Stephanie Bunt, Lingling Yang, P. Sinha, V. Clements, Jeff Leips, S. Ostrand-Rosenberg (2007)
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.Cancer research, 67 20
Ying-Wen Su, T. Xie, D. Sano, J. Myers (2011)
IL-6 Stabilizes Twist and Enhances Tumor Cell Motility in Head and Neck Cancer Cells through Activation of Casein Kinase 2PLoS ONE, 6
(2007)
Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
P. Sinha, V. Clements, S. Ostrand-Rosenberg (2005)
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease1The Journal of Immunology, 174
J. B. Mumm, J. Emmerich, X. Zhang, I. Chan, L. Wu, S. Mauze, S. Blaisdell, B. Basham, J. Dai, J. Grein, C. Sheppard, K. Hong, C. Cutler, S. Turner, D. LaFace, M. Kleinschek, M. Judo, G. Ayanoglu, J. Langowski, D. Gu, B. Paporello, E. Murphy, V. Sriram, S. Naravula, B. Desai, S. Medicherla, W. Seghezzi, T. McClanahan, S. Cannon‐Carlson, A. M. Beebe, M. Oft (2011)
IL‐10 elicits IFNgamma‐dependent tumor immune surveillance, 20
S. Shiao, Ganesan Ap, Ganesan Ap, H. Rugo, L. Coussens (2011)
Immune microenvironments in solid tumors: new targets for therapy.Genes & development, 25 24
B. Lippitz (2013)
Cytokine patterns in patients with cancer: a systematic review.The Lancet. Oncology, 14 6
C. Becker, M. Fantini, S. Wirtz, A. Nikolaev, H. Lehr, P. Galle, Stefan Rose-John, M. Neurath (2005)
IL-6 Signaling Promotes Tumor Growth in Colorectal CancerCell Cycle, 4
D. Berg, N. Davidson, R. Kühn, Werner Müller, S. Menon, G. Holland, L. Thompson-Snipes, M. Leach, D. Rennick (1996)
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.The Journal of clinical investigation, 98 4
F. Jacobs, D. Chaussabel, C. Truyens, V. Leclerq, Y. Carlier, M. Goldman, B. Vray (1998)
IL‐10 up‐regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)‐activated macrophages: improved control of Trypanosoma cruzi infectionClinical & Experimental Immunology, 113
Hirotake Tsukamoto, Ryutaro Nishikata, S. Senju, Y. Nishimura (2013)
Myeloid-Derived Suppressor Cells Attenuate TH1 Development through IL-6 Production to Promote Tumor ProgressionCancer Immunology Research, 1
Courtney Smith, M. Chang, Katherine Parker, Daniel Beury, J. DuHadaway, Hollie Flick, Janette Boulden, E. Sutanto‐Ward, A. Soler, L. Laury-Kleintop, L. Mandik-Nayak, R. Metz, S. Ostrand-Rosenberg, G. Prendergast, A. Muller (2012)
IDO is a nodal pathogenic driver of lung cancer and metastasis development.Cancer discovery, 2 8
J. Emmerich, J. Mumm, I. Chan, D. Laface, H. Truong, T. Mcclanahan, D. Gorman, M. Oft (2012)
IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs.Cancer research, 72 14
V. Bronte, P. Zanovello (2005)
Regulation of immune responses by L-arginine metabolismNature Reviews Immunology, 5
D. Gabrilovich, S. Ostrand-Rosenberg, V. Bronte (2012)
Coordinated regulation of myeloid cells by tumoursNature Reviews Immunology, 12
Stephanie Bunt, P. Sinha, V. Clements, Jeff Leips, S. Ostrand-Rosenberg (2006)
Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression1The Journal of Immunology, 176
Sinha (2007)
977J. Immunol., 179
Johanna Morales, Sheinei Saleem, Rebecca Martin, Bryan Saunders, B. Barnstein, Travis Faber, Nicholas Pullen, E. Kolawole, Keith Brooks, Sarah Norton, J. Sturgill, L. Graham, H. Bear, J. Urban, C. Lantz, D. Conrad, J. Ryan (2014)
Myeloid‐derived suppressor cells enhance IgE‐mediated mast cell responsesJournal of Leukocyte Biology, 95
F. Balkwill (2006)
TNF-alpha in promotion and progression of cancer.Cancer metastasis reviews, 25 3
Takami Sato, M. Terai, Y. Tamura, V. Alexeev, M. Mastrangelo, S. Selvan (2011)
Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapyImmunologic Research, 51
Stephanie Bunt, V. Clements, E. Hanson, P. Sinha, S. Ostrand-Rosenberg (2009)
Inflammation enhances myeloid‐derived suppressor cell cross‐talk by signaling through Toll‐like receptor 4Journal of Leukocyte Biology, 85
P. Sinha, Katherine Parker, Lucas Horn, S. Ostrand-Rosenberg (2012)
Tumor‐induced myeloid‐derived suppressor cell function is independent of IFN‐γ and IL‐4RαEuropean Journal of Immunology, 42
Ilaria Marigo, E. Bosio, S. Solito, C. Mesa, Audry Fernández, L. Dolcetti, S. Ugel, N. Sonda, S. Bicciato, Erika Falisi, F. Calabrese, G. Basso, P. Zanovello, E. Cozzi, S. Mandruzzato, V. Bronte (2010)
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.Immunity, 32 6
S. Mocellin, F. Marincola, H. Young (2005)
Interleukin‐10 and the immune response against cancer: a counterpointJournal of Leukocyte Biology, 78
Jae‐Ho Lee, G. Lee, S. Woo, Y. Ha, S. Kwon, Wun-Jae Kim, I. Kim (2013)
BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages.Cancer research, 73 12
F. Vallania, D. Schiavone, S. Dewilde, Emanuela Pupo, S. Garbay, R. Calogero, M. Pontoglio, P. Provero, V. Poli (2009)
Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3Proceedings of the National Academy of Sciences, 106
A. Hutchins, Diego Diez, Diego Miranda-Saavedra (2013)
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challengesBriefings in Functional Genomics, 12
T. Tanikawa, C. Wilke, Ilona Kryczek, Grace Chen, J. Kao, G. Núñez, W. Zou (2012)
Interleukin-10 ablation promotes tumor development, growth, and metastasis.Cancer research, 72 2
S. Ostrand‐Rosenberg, P. Sinha (2009)
Myeloid‐derived suppressor cells: linking inflammation and cancer, 182
W. Ouyang, S. Rutz, N. Crellin, P. Valdez, S. Hymowitz (2011)
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.Annual review of immunology, 29
C. Niemand, A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. Heinrich, G. Müller-Newen (2003)
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3 1The Journal of Immunology, 170
K. Dennis, Y. Wang, N. Blatner, S. Wang, A. Saadalla, E. Trudeau, Axel Roers, C. Weaver, J. Lee, J. Gilbert, E. Chang, K. Khazaie (2013)
Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.Cancer research, 73 19
Ostrand-Rosenberg (2009)
4499J. Immunol., 182
F. Balkwill (2006)
TNF-α in promotion and progression of cancerCancer and Metastasis Reviews, 25
S. Hussain, G. Trivers, L. Hofseth, Peijun He, Irfan Shaikh, Leah Mechanic, S. Doja, Weidong Jiang, J. Subleski, Lynnette Shorts, D. Haines, V. Laubach, R. Wiltrout, D. Djurickovic, C. Harris (2004)
Nitric Oxide, a Mediator of Inflammation, Suppresses TumorigenesisCancer Research, 64
Interactions between MDSC, macrophages, and tumor cells alter the cytokine milieu, impacting inflammation in the tumor microenvironment.
Journal of Leukocyte Biology – Oxford University Press
Published: Aug 28, 2014
Keywords: cancer; cytokines; tumor microenvironment; IL-6; IL-10; nitric oxide
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.