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- Publisher
- Springer Journals
- Copyright
- Copyright © 2000 by Macmillan Magazines Ltd.
- Subject
- Life Sciences; Life Sciences, general; Cell Biology; Cancer Research; Developmental Biology; Stem Cells; Biochemistry, general
- ISSN
- 1471-0072
- eISSN
- 1471-0080
- DOI
- 10.1038/35036093
- Publisher site
- See Article on Publisher Site
Abstract
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick limit’. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.
Journal
Nature Reviews Molecular Cell Biology – Springer Journals
Published: Oct 1, 2000