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Relationship Between Endometriosis, Endometrioid Adenocarcinoma, Gliomatosis Peritonei, and Carcinoid Tumor in a Patient With Recurrent Ovarian Teratoma

Relationship Between Endometriosis, Endometrioid Adenocarcinoma, Gliomatosis Peritonei, and... International Journal of Gynecological Pathology 30:151–157, Lippincott Williams & Wilkins, Baltimore r 2011 International Society of Gynecological Pathologists Case Report Relationship Between Endometriosis, Endometrioid Adenocarcinoma, Gliomatosis Peritonei, and Carcinoid Tumor in a Patient With Recurrent Ovarian Teratoma Mary Alexander, M.A., M.B., B.Chir., F.R.C.Path, Nichola Cope, M.A., M.B., Ch.B., F.R.C.Path, John Renninson, M.B., Ch.B., M.R.C.O.G., D.A. (UK)., Ann Hong, F.R.C.P., F.R.C.R, Roderick H.W. Simpson, B.Sc., M.B. Ch.B., M.Med., F.R.C.Path., Raji Ganesan, M.B.B.S., F.R.C.Path., and Lynn Hirschowitz, M.B.B.Ch., F.R.C.Path Summary: Gliomatosis peritonei (GP) describes the implantation of mature neuroglial tissue in the peritoneum and is usually associated with mature ovarian teratoma but is also found in cases of immature teratoma. We report the case of a patient with recurrent mature ovarian teratoma, GP, endometriosis (with malignant transformation), and carcinoid tumor, found at the time of hysterectomy for a primary endometrial adenocarcinoma. This unusual combination of tumor types has not been reported earlier. Metaplasia of the totipotential subcoelomic or submesothelial stem cells is a recognized pathway for the development of endometriosis. Evidence from molecular genetic studies suggests that a similar process of stem cell differentiation may explain at least some cases of GP. The coexistence (and colocalization) of endometriosis, GP, and carcinoid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Gynecological Pathology Wolters Kluwer Health

Relationship Between Endometriosis, Endometrioid Adenocarcinoma, Gliomatosis Peritonei, and Carcinoid Tumor in a Patient With Recurrent Ovarian Teratoma

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References (23)

Copyright
© 2011 International Society of Gynecological Pathologists
ISSN
0277-1691
eISSN
1538-7151
DOI
10.1097/PGP.0b013e3181f6bcd4
pmid
21293285
Publisher site
See Article on Publisher Site

Abstract

International Journal of Gynecological Pathology 30:151–157, Lippincott Williams & Wilkins, Baltimore r 2011 International Society of Gynecological Pathologists Case Report Relationship Between Endometriosis, Endometrioid Adenocarcinoma, Gliomatosis Peritonei, and Carcinoid Tumor in a Patient With Recurrent Ovarian Teratoma Mary Alexander, M.A., M.B., B.Chir., F.R.C.Path, Nichola Cope, M.A., M.B., Ch.B., F.R.C.Path, John Renninson, M.B., Ch.B., M.R.C.O.G., D.A. (UK)., Ann Hong, F.R.C.P., F.R.C.R, Roderick H.W. Simpson, B.Sc., M.B. Ch.B., M.Med., F.R.C.Path., Raji Ganesan, M.B.B.S., F.R.C.Path., and Lynn Hirschowitz, M.B.B.Ch., F.R.C.Path Summary: Gliomatosis peritonei (GP) describes the implantation of mature neuroglial tissue in the peritoneum and is usually associated with mature ovarian teratoma but is also found in cases of immature teratoma. We report the case of a patient with recurrent mature ovarian teratoma, GP, endometriosis (with malignant transformation), and carcinoid tumor, found at the time of hysterectomy for a primary endometrial adenocarcinoma. This unusual combination of tumor types has not been reported earlier. Metaplasia of the totipotential subcoelomic or submesothelial stem cells is a recognized pathway for the development of endometriosis. Evidence from molecular genetic studies suggests that a similar process of stem cell differentiation may explain at least some cases of GP. The coexistence (and colocalization) of endometriosis, GP, and carcinoid

Journal

International Journal of Gynecological Pathology – Wolters Kluwer Health

Published: Mar 1, 2011

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