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Effects of depression on cognitive function in patients with diabetes in different age groups

Effects of depression on cognitive function in patients with diabetes in different age groups Aims To investigate the effects of depression on cognitive function in patients of different ages with diabetes mellitus (DM). Methods 6,549 patients with DM who were assessed using the Mini-Mental State Examination (MMSE) and Self-Rating Depression Scale (SDS) in 2016 were selected from the 2016 Kailuan Group staff physical examinations. Generalized linear regression models were used to analyze the effects of SDS index score on MMSE score in DM patients in different age groups. We also analyzed the effects of SDS index score on MMSE score in DM patients with different risk factors. Results Generalized linear regression analysis showed that higher SDS index score was associated with lower MMSE score (β = −0.06; P < 0.01). In addition, there was an interaction effect between SDS index score and age groups on cognitive function. Meanwhile, SDS index score also has an interaction effect with level of education. Conclusions The negative association between the degree of depression and cognitive function level increases with age in DM patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical and Experimental Neuropsychology Taylor & Francis

Effects of depression on cognitive function in patients with diabetes in different age groups

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References (37)

Publisher
Taylor & Francis
Copyright
© 2023 Informa UK Limited, trading as Taylor & Francis Group
ISSN
1744-411x
eISSN
1380-3395
DOI
10.1080/13803395.2023.2228016
Publisher site
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Abstract

Aims To investigate the effects of depression on cognitive function in patients of different ages with diabetes mellitus (DM). Methods 6,549 patients with DM who were assessed using the Mini-Mental State Examination (MMSE) and Self-Rating Depression Scale (SDS) in 2016 were selected from the 2016 Kailuan Group staff physical examinations. Generalized linear regression models were used to analyze the effects of SDS index score on MMSE score in DM patients in different age groups. We also analyzed the effects of SDS index score on MMSE score in DM patients with different risk factors. Results Generalized linear regression analysis showed that higher SDS index score was associated with lower MMSE score (β = −0.06; P < 0.01). In addition, there was an interaction effect between SDS index score and age groups on cognitive function. Meanwhile, SDS index score also has an interaction effect with level of education. Conclusions The negative association between the degree of depression and cognitive function level increases with age in DM patients.

Journal

Journal of Clinical and Experimental Neuropsychology – Taylor & Francis

Published: Mar 16, 2023

Keywords: Depression; age cognitive function; diabetes mellitus; interaction effect

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