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References (26)
-
F. Moya, L. Glaser (1980)
Dissociation of cell density and cell cycle effects on the rate of transport of alpha-aminoisobutyric acid in 3T3 cells.The Journal of biological chemistry, 255 8
-
James Smith, Jagmeet Singh, J. Lillquist, D. Goon, C. Stiles (1982)
Growth factors adherent to cell substrate are mitogenically active in situNature, 296
-
Michael Brown, J. Goldstein (1976)
Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoproteinCell, 9
-
S. Dana, M. Brown, J. Goldstein (1977)
Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads.Biochemical and biophysical research communications, 74 4
-
J. Aggeler, L. Kapp, S. Tseng, Z. Werb (1982)
Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density. Plasminogen activator, procollagen fibronectin.Experimental cell research, 139 2
-
S. Imada, M. Imada (1982)
Increase of a surface glycoprotein by cyclic AMP in Chinese hamster ovary cells. Dependence on cell-cell interaction.The Journal of biological chemistry, 257 15
-
I. Vlodavsky, P. Fielding, C. Fielding, D. Gospodarowicz (1978)
Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells.Proceedings of the National Academy of Sciences of the United States of America, 75 1
-
C. Floren, J. Albers, B. Kudchodkar, E. Bierman (1981)
Receptor-dependent uptake of human chylomicron remnants by cultured skin fibroblasts.The Journal of biological chemistry, 256 1
-
H. Ahn, S. Horowitz, H. Eagle, M. Makman (1978)
Effects of cell density and cell growth alterations on cyclic nucleotide levels in cultured human diploid fibroblasts.Experimental cell research, 114 1
-
D. Clemmons, L. Underwood, J. Wyk (1981)
Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts.The Journal of clinical investigation, 67 1
-
D. Gal, P. Macdonald, J. Porter, J. Smith, E. Simpson (1981)
Effect of cell density and confluency on cholesterol metabolism in cancer cells in monolayer culture.Cancer research, 41 2
-
L. Witte, J. Cornicelli (1980)
Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.Proceedings of the National Academy of Sciences of the United States of America, 77 10
-
M. Stoker (1973)
Role of Diffusion Boundary Layer in Contact Inhibition of GrowthNature, 246
-
A. Chait, R. Ross, J. Albers, E. Bierman (1980)
Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.Proceedings of the National Academy of Sciences of the United States of America, 77 7
-
J. Smith, C. Stiles (1981)
Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor.Proceedings of the National Academy of Sciences of the United States of America, 78 7
-
W. Sasak, A. Herscovics, A. Quaroni (1982)
Cell-density-dependent changes in cell-surface glycopeptides and in adhesion of cultured intestinal epithelial cells.The Biochemical journal, 201 2
-
O. Stein, Y. Stein (1975)
Surface binding and interiorization of homologous and heterologous serum lipoproteins by rat aortic smooth muscle cells in culture.Biochimica et biophysica acta, 398 3
-
Edwin Bierman, John Albers (1975)
Lipoprotein uptake by cultured human arterial smooth muscle cells.Biochimica et biophysica acta, 388 2
-
R. Anderson, Michael Brown, J. Goldstein (1981)
Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cellsThe Journal of Cell Biology, 88
-
Platelet-derived Growth Factor -
D. Bilheimer, S. Eisenberg, R. Levy (1972)
The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations.Biochimica et biophysica acta, 260 2
-
A. Chait, E. Bierman, J. Albers (1979)
Low Density Lipoprotein Receptor Activity in Fibroblasts Cultured from Diabetic DonorsDiabetes, 28
-
A. Vogel, R. Ross, E. Raines (1980)
Role of serum components in density-dependent inhibition of growth of cells in culture. Platelet-derived growth factor is the major serum determinant of saturation densityThe Journal of Cell Biology, 85
-
H. Kruth, J. Avigan, W. Gamble, M. Vaughan (1979)
Effect of cell density on binding and uptake of low density lipoprotein by human fibroblastsThe Journal of Cell Biology, 83
-
P. Davies, R. Ross (1978)
Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factorThe Journal of Cell Biology, 79
-
E. Bierman, O. Stein, Y. Stein (1974)
Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue CultureCirculation Research, 35
- Publisher
- Wiley
- Copyright
- Copyright © 1983 Wiley‐Liss, Inc.
- ISSN
- 0021-9541
- eISSN
- 1097-4652
- DOI
- 10.1002/jcp.1041160319
- pmid
- 6309872
- Publisher site
- See Article on Publisher Site
Abstract
10.1002/jcp.1041160319.abs Stimulation of the proliferation of human skin fibroblasts by platelet‐derived growth factor increased the binding and degradation of low‐density lipoproteins at cell densities of 2000–30,000 cells/cm2. Binding and degradation of low‐density lipoprotein was an inverse function of cell density in both proliferating and quiescent cells, indicating that the effect of cell density on the LDL receptor has proliferation‐dependent and proliferation‐independent components. The effect of medium conditioned by confluent fibroblasts on LDL metabolism was tested to determine if the effects of cell density on LDL metabolism might be mediated by cellular secretion products. Fibroblast‐conditioned medium increased LDL metabolism, suggesting secretion products do not mediate these effects of cell density. These data indicate that regulation of the low‐density lipoprotein receptor is not a simple on/off response to growth stimulation, but is responsive to extracellular cues such as cell density.
Journal
Journal of Cellular Physiology – Wiley
Published: Sep 1, 1983