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References (23)
-
P. Bőhlen, F. Esch, A. Baird, D. Gospodarowicz (1985)
Acidic fibroblast growth factor (FGF) from bovine brain: amino‐terminal sequence and comparison with basic FGF.The EMBO Journal, 4
-
J. Huang, S. Huang, B. Kennedy, T. Deuel (1982)
Platelet-derived growth factor. Specific binding to target cells.The Journal of biological chemistry, 257 14
-
D. Gospodarowicz (1984)
Biological activity in vivo and in vitro of pituitary and brain fibroblast growth factor.Symposium on Fundamental Cancer Research, 37
-
Denis GOSPODAROWlCZ, J. Lépine, S. Massoglia, Irmagard Wood (1984)
Comparison of the ability of basement membranes produced by corneal endothelial and mouse-derived Endodermal PF-HR-9 cells to support the proliferation and differentiation of bovine kidney tubule epithelial cells in vitroThe Journal of Cell Biology, 99
-
P. Bőhlen, A. Baird, F. Esch, N. Ling, D. Gospodarowicz (1984)
Isolation and partial molecular characterization of pituitary fibroblast growth factor.Proceedings of the National Academy of Sciences of the United States of America, 81 17
-
Stephanie Taylor, J. Folkman (1982)
Protamine is an inhibitor of angiogenesisNature, 297
-
G. Neufeld, D. Gospodarowicz (1985)
The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.The Journal of biological chemistry, 260 25
-
D. Gospodarowicz, A. Mescher, C. Birdwell (1978)
Control of cellular proliferation by the fibroblast and epidermal growth factors.National Cancer Institute monograph, 48
-
C. Savage, S. Cohen (1972)
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.The Journal of biological chemistry, 247 23
-
D. Gospodarowicz, J. Tauber (1980)
Growth factors and the extracellular matrix.Endocrine reviews, 1 3
-
S. Majewski, M. Kamińki, A. Szmurło, G. Kamińska, J. Malejczyk (1984)
Inhibition of tumour‐induced angiogenesis by systemically administered protamine sulphateInternational Journal of Cancer, 33
-
G. Neufeld, S. Massoglia, D. Gospodarowicz (1986)
Effect of lipoproteins and growth factors on the proliferation of BHK-21 cells in serum free cultureRegulatory Peptides, 13
-
(1986)
Purification of brain and pituitary FGF -
D. West, I. Hampson, F. Arnold, S. Kumar (1985)
Angiogenesis induced by degradation products of hyaluronic acid.Science, 228 4705
-
G. Neufeld, D. Gospodarowicz, Linda Dodge, D. Fujii (1987)
Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cellsJournal of Cellular Physiology, 131
-
D. Gospodarowicz, G. Neufeld, Lothar Schweigerer (1986)
Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells.Cell differentiation, 19 1
-
Alan R. Liss, Inc. -
G. Greenburg, D. Gospodarowicz (1982)
Inactivation of a basement membrane component responsible for cell proliferation but not for cell attachment.Experimental cell research, 140 1
-
B. Olwin, S. Hauschka (1986)
Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts.Biochemistry, 25 12
-
D. Gospodarowicz, S. Massoglia, J. Cheng, D. Fujii (1986)
Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillariesJournal of Cellular Physiology, 127
-
(1984)
Preparation of extracellular matrices produced by cultured bovine corneal endothelial cells and PF - HR - 9 ter - atocarcinoma cells : Their use in the study of cell proliferation and differentiation -
G. Neufeld, D. Gospodarowicz (1986)
Basic and acidic fibroblast growth factors interact with the same cell surface receptors.The Journal of biological chemistry, 261 12
-
F. Esch, N. Ueno, A. Baird, Fred Hill, L. Denoroy, N. Ling, D. Gospodarowicz, R. Guillemin (1985)
Primary structure of bovine brain acidic fibroblast growth factor (FGF).Biochemical and biophysical research communications, 133 2
- Publisher
- Wiley
- Copyright
- Copyright © 1987 Wiley‐Liss, Inc.
- ISSN
- 0021-9541
- eISSN
- 1097-4652
- DOI
- 10.1002/jcp.1041320213
- pmid
- 3497929
- Publisher site
- See Article on Publisher Site
Abstract
10.1002/jcp.1041320213.abs Protamine sulfate, an inhibitor of angiogenesis in vivo, markedly inhibits the ability of angiogenic factors such as acidic or basic fibroblast growth factor (aFGF, bFGF) to stimulate the proliferation in vitro of either BHK‐21 cells or vascular endothelial cells. The inhibition is reversible, and cells remain viable even after prolonged exposure to protamine sulfate. Protamine sulfate inhibits the mitogenic effects of both growth factors by preventing them from binding to their common cell surface receptors. It also inhibits the mitogenic activity of the extracellular matrix produced by bovine corneal endothelial cells. This substrate has been shown in previous studies to replace the requirement for FGF of many cell types. In contrast, protamine sulfate potentiates the mitogenic activity of epidermal growth factor (EGF). This indicates that protamine sulfate also acts at cellular sites which are not associated with FGF receptors.
Journal
Journal of Cellular Physiology – Wiley
Published: Aug 1, 1987