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Indirect measures of gene flow and migration: F ST≠1/(4Nm+1)

Indirect measures of gene flow and migration: F ST≠1/(4Nm+1) The difficulty of directly measuring gene flow has lead to the common use of indirect measures extrapolated from genetic frequency data. These measures are variants of F ST, a standardized measure of the genetic variance among populations, and are used to solve for Nm, the number of migrants successfully entering a population per generation. Unfortunately, the mathematical model underlying this translation makes many biologically unrealistic assumptions; real populations are very likely to violate these assumptions, such that there is often limited quantitative information to be gained about dispersal from using gene frequency data. While studies of genetic structure per se are often worthwhile, and F ST is an excellent measure of the extent of this population structure, it is rare that F ST can be translated into an accurate estimate of Nm. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heredity Springer Journals

Indirect measures of gene flow and migration: F ST≠1/(4Nm+1)

Whitlock, Michael C; McCauley, David E
Heredity , Volume 82 (2) – Feb 1, 1999
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References (59)

Publisher
Springer Journals
Copyright
Copyright © 1999 by The Genetical Society of Great Britain
Subject
Biomedicine; Biomedicine, general; Human Genetics; Evolutionary Biology; Ecology; Cytogenetics; Plant Genetics and Genomics
ISSN
0018-067X
eISSN
1365-2540
DOI
10.1038/sj.hdy.6884960
Publisher site
See Article on Publisher Site

Abstract

The difficulty of directly measuring gene flow has lead to the common use of indirect measures extrapolated from genetic frequency data. These measures are variants of F ST, a standardized measure of the genetic variance among populations, and are used to solve for Nm, the number of migrants successfully entering a population per generation. Unfortunately, the mathematical model underlying this translation makes many biologically unrealistic assumptions; real populations are very likely to violate these assumptions, such that there is often limited quantitative information to be gained about dispersal from using gene frequency data. While studies of genetic structure per se are often worthwhile, and F ST is an excellent measure of the extent of this population structure, it is rare that F ST can be translated into an accurate estimate of Nm.

Journal

Heredity – Springer Journals

Published: Feb 1, 1999

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