Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells Lymphocytes that are responsible for regional (tissue-specific) immunity home from the blood to the intestines, inflamed skin or other sites through a multistep process involving recognition of vascular endothelial cells and extravasation 1 . Chemoattractant cytokine molecules known as chemokines 2 regulate this lymphocyte traffic, in part by triggering arrest (stopping) of lymphocytes rolling on endothelium 3,4,5 . Here we show that many systemic memory T cells in blood carry the chemokine receptor CCR4 (ref. 6) and therefore respond to its ligands, the chemokines TARC and MDC. These cells include essentially all skin-homing cells expressing the cutaneous lymphocyte antigen and a subset of other systemic memory lymphocytes; however, intestinal (α4β7+) memory and naive T cells respond poorly. Immunohistochemistry reveals anti-TARC reactivity of venules and infiltration of many CCR4+ lymphocytes in chronically inflamed skin, but not in the gastrointestinal lamina propria. Moreover, TARC induces integrin-dependent adhesion of skin (but not intestinal) memory T cells to the cell-adhesion molecule ICAM-1, and causes their rapid arrest under physiological flow. Our results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

Download PDF
5 pages

Loading next page...
 
/lp/springer-journals/the-chemokine-receptor-ccr4-in-vascular-recognition-by-cutaneous-but-l3R9dGVvjv

References (30)

Publisher
Springer Journals
Copyright
Copyright © 1999 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/23495
Publisher site
See Article on Publisher Site

Abstract

Lymphocytes that are responsible for regional (tissue-specific) immunity home from the blood to the intestines, inflamed skin or other sites through a multistep process involving recognition of vascular endothelial cells and extravasation 1 . Chemoattractant cytokine molecules known as chemokines 2 regulate this lymphocyte traffic, in part by triggering arrest (stopping) of lymphocytes rolling on endothelium 3,4,5 . Here we show that many systemic memory T cells in blood carry the chemokine receptor CCR4 (ref. 6) and therefore respond to its ligands, the chemokines TARC and MDC. These cells include essentially all skin-homing cells expressing the cutaneous lymphocyte antigen and a subset of other systemic memory lymphocytes; however, intestinal (α4β7+) memory and naive T cells respond poorly. Immunohistochemistry reveals anti-TARC reactivity of venules and infiltration of many CCR4+ lymphocytes in chronically inflamed skin, but not in the gastrointestinal lamina propria. Moreover, TARC induces integrin-dependent adhesion of skin (but not intestinal) memory T cells to the cell-adhesion molecule ICAM-1, and causes their rapid arrest under physiological flow. Our results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues.

Journal

Nature – Springer Journals

Published: Aug 19, 1999

There are no references for this article.